Protein Overview: ABC1

General Information:
Name(s) found:	ABC1 / YGL119W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321319\|ref\|NP_011396.1\| Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone b [NCBI NR] gi\|3320\|emb\|CAA41759.1\| ABC1 [Saccharomyces cerevisiae] [NCBI NR] gi\|1322675\|emb\|CAA96827.1\| ABC1 [Saccharomyces cerevisiae] [NCBI NR] gi\|112996\|sp\|P27697.1\|ABC1_YEAST RecName: Full=Protein ABC1, mitochondrial; Flags: Precursor [NCBI NR] pir\|\|S16711 ABC1 protein precursor - yeast (Saccharomyces cerevisiae) [NCBI NR] Protein ABC1, mitochondrial OS=Saccharomyces cerevisiae GN=ABC1 PE=1 SV=1 [Swiss-Prot] ABC1 Ubiquinol--cytochrome-c reductase complex assembly protein [mips] Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis [SGD] ABC1, Chr VII from 284443-285948 [yeast_orfs2] Chr VII from 284443-285948 [yeastorf3.fasta] Chr VII from 284446-285951 [yeastorf4.fasta] (P27697) ABC1 protein, mitochondrial precursor [4932.FASTACCERV.txt] ABC1 SGDID:S0003087, Chr VII from 284446-285951, Verified ORF [yeastflysequest.fasta] ABC1 SGDID:S0003087, Chr VII from 284448-285953, Verified ORF [10112005cervSGD.fasta] Abc1p [Saccharomyces cerevisiae]gi\|1322675\|emb\|CAA96827.1\| ABC1 [Saccharomyces cerevisiae]gi\|3320\|emb\|CAA41759.1\| ABC1 [Saccharomyces cerevisiae]gi\|101650\|pir\|\|S16711 ABC1 protein precursor - yeast (Saccharomyces cerevisiae)gi\|112996\|sp\|P27697\|ABC1_YE [nrdb_11152004_Chlamydomonas] ABC1 SGDID:S000003087, Chr VII from 284448-285953, Verified ORF, "Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins i [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] ABC1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein ABC1, mitochondrial precursor [nr-271106-contam.fasta] Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; Abc1p [Saccharo [nr-271106-contam.fasta] ABC1 SGDID:S000003087, Chr VII from 284448-285953, Verified ORF, "Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis" [yeast-bovrabprots.fasta] [chemostatdb.fasta] COQ8 SGDID:S000003087, Chr VII from 284442-285947, Genome Release 64-1-1, Verified ORF, "Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis" [yeast-030211-contam.fasta] COQ8 SGDID:S000003087, Chr VII from 284442-285947, Genome Release 64-2-1, Verified ORF, "Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YGL119W SGDID:S000003087, Chr VII from 284442-285947, Genome Release 64-1-1, Verified ORF, "Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	501 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ][ISS]
Biological Process:	aerobic respiration [IMP] ubiquinone biosynthetic process [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTNMVKLRN LRRLYCSSRL LRTIQNGRIS SVSSISLSKK YTTKSAKEGE ENVERKHEEE  60
   61 KKDTLKSSSV PTSRISRLFH YGSLAAGVGM NAAAKGISEV AKGNSPTWKS LILSDSNIDR 120
  121 ITNKFSKMRG VALKIGQLLS FQDEKVLPKE LYEILSRVQN SANHMPQRQL EKVMAKELGA 180
  181 NWKTKFSKFD KIPMAAASIG QVHAAELPSG QRVVVKIQYP GVKESIDSDL NSLLMLLTAS 240
  241 SLLPKGLFLD KTIANARTEL KWECDYNREA RALQKFEALL KDDPAFEVPH VFPEYTTDNI 300
  301 ITMTRMEGTE IMKLPKASQE TKNFISENIM RLCLEEIATF KYMQTDPNWA NFLYNGRTKK 360
  361 IELLDFGASR PFAEDFILKY RKLLTYATLR DRKGAYEMSV QLGYLTGLES QSMKDAHVDS 420
  421 VLTLGEPFRG DVDKSFDFKD QTVSDRIRGN IGLMLNERLC PPPEETYSLH RKFSGIFLLC 480
  481 ARMGASVHCA KLFKEIFAYK V

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#11 Mitotic Prep1-TiO2 enriched, new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	THG1	ABC1	1	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	ABC1	Huh WK, et al. (2003)

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..104]	deduced	N/A	No confident structure predictions are available.
2	View Details	[105..180]	PSI-BLAST	11.154902	Hemapoetic cell kinase Hck; Hemopoetic cell kinase Hck; Haemopoetic cell kinase Hck
3	View Details	[181..308]	PSI-BLAST	60.69897	Calmodulin-dependent protein kinase
4	View Details	[309..501]	PSI-BLAST	60.69897	Calmodulin-dependent protein kinase

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.88

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2