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Protein Overview: MF(ALPHA)2

General Information:
Name(s) found: MF(ALPHA)2 / YGL089C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 120 amino acids

    Gene Ontology:
    Cellular Component: extracellular region [TASLink to PubMed article]
    Biological Process: pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMPLink to PubMed article]
    Molecular Function: mating pheromone activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFISTFLTF ILAAVSVTAS SDEDIAQVPA EAIIGYLDFG GDHDIAFLPF SNATASGLLF  60
   61 INTTIAEAAE KEQNTTLAKR EAVADAWHWL NLRPGQPMYK REANADAWHW LQLKPGQPMY 120
  121

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) MF(ALPHA)1 MF(ALPHA)2 MFA1 MFA2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..120] Pfam 56.585027 No description for PF05436.2 was found. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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