Protein Overview: AFT1

General Information:
Name(s) found:	AFT1 / YGL071W [SGD]
Description(s) found: Found 29 descriptions. SHOW ALL	Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability [SGD]
Organism:	Saccharomyces cerevisiae
Length:	690 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	high-affinity iron ion transport [IMP][IPI] positive regulation of transcription from RNA polymerase II promoter [IDA][IMP][IPI]
Molecular Function:	transcription factor activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGFNPADIE HASPINSSDS HSSSFVYALP KSASEYVVNH NEGRASASGN PAAVPSPIMT  60
   61 LNLKSTHSLN IDQHVHTSTS PTETIGHIHH VEKLNQNNLI HLDPVPNFED KSDIKPWLQK 120
  121 IFYPQGIELV IERSDAFKVV FKCKAAKRGR NARRKRKDKP KGQDHEDEKS KINDDELEYA 180
  181 SPSNATVTNG PQTSPDQTSS IKPKKKRCVS RFNNCPFRVR ATYSLKRKRW SIVVMDNNHS 240
  241 HQLKFNPDSE EYKKFKEKLR KDNDVDAIKK FDELEYRTLA NLPIPTATIP CDCGLTNEIQ 300
  301 SFNVVLPTNS NVTSSASSST VSSISLDSSN ASKRPCLPSV NNTGSINTNN VRKPKSQCKN 360
  361 KDTLLKRTTM QNFLTTKSRL RKTGTPTSSQ HSSTAFSGYI DDPFNLNEIL PLPASDFKLN 420
  421 TVTNLNEIDF TNIFTKSPHP HSGSTHPRQV FDQLDDCSSI LFSPLTTNTN NEFEGESDDF 480
  481 VHSPYLNSEA DFSQILSSAP PVHHDPNETH QENQDIIDRF ANSSQEHNEY ILQYLTHSDA 540
  541 ANHNNIGVPN NNSHSLNTQH NVSDLGNSLL RQEALVGSSS TKIFDELKFV QNGPHGSQHP 600
  601 IDFQHVDHRH LSSNEPQVRS HQYGPQQQPP QQLQYHQNQP HDGHNHEQHQ TVQKDMQTHE 660
  661 SLEIMGNTLL EEFKDIKMVN GELKYVKPED

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CIA1	AFT1	2	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	AFT1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..374]	deduced	N/A	No confident structure predictions are available.
2	View Details	[375..690]	ORFEUS	7.0	Haloperoxidase (bromoperoxidase)

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
catalytic activity	0.732568437339568	bayes_pls_golite062009
hydrolase activity	0.203510976989008	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2