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Protein Overview: GYP8

General Information:
Name(s) found: GYP8 / YFL027C [SGD]
Description(s) found:
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  • gi|836727|dbj|BAA09211.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51013725|gb|AAT93156.1| YFL027C [Saccharomyces cerevisiae] [NCBI NR]
  • gi|16740526|ref|NP_444296.1| GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport; Gyp8p [Saccharomyces cer [NCBI NR]
  • gi|1175935|sp|P43570.1|GYP8_YEAST RecName: Full=GTPase-activating protein GYP8 [NCBI NR]
  • pir||S56227 probable membrane protein YFL027c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • GTPase-activating protein GYP8 OS=Saccharomyces cerevisiae GN=GYP8 PE=1 SV=1 [Swiss-Prot]
  • GYP8 GTPase-activating protein for yeast Rab family members, involved in the regulation of ER to Golgi vesicle transport [mips]
  • GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport [SGD]
  • YFL027C, Chr VI from 80417-81910, reverse complement [yeast_orfs2]
  • Chr VI from 80417-81910, reverse complement [yeastorf3.fasta]
  • Chr VI from 81910-80417, reverse complement [yeastorf5.fasta]
  • (P43570) GTPase-activating protein GYP8 [4932.FASTACCERV.txt]
  • GYP8 SGDID:S0001867, Chr VI from 81910-80417, reverse complement, Verified ORF [yeastflysequest.fasta]
  • GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport [Saccharomyces cerevisiae]gi|51013725|gb|AAT93156.1| [nrdb_11152004_Chlamydomonas]
  • GYP8 SGDID:S000001867, Chr VI from 81910-80417, reverse complement, Verified ORF, "GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of E [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YFL027C [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport; Gyp8p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • GTPase-activating protein GYP8 [nr-271106-contam.fasta]
  • GYP8 SGDID:S000001867, Chr VI from 81910-80417, reverse complement, Verified ORF, "GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • GTPase-activating protein GYP8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GYP8 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • GYP8 SGDID:S000001867, Chr VI from 81912-80419, Genome Release 64-1-1, reverse complement, Verified ORF, "GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport" [yeast-030211-contam.fasta]
  • GYP8 SGDID:S000001867, Chr VI from 81912-80419, Genome Release 64-2-1, reverse complement, Verified ORF, "GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport" [20141208_orf_trans.fasta]
  • YFL027C SGDID:S000001867, Chr VI from 81912-80419, Genome Release 64-1-1, reverse complement, Verified ORF, "GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 497 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IDALink to PubMed article]
    Biological Process: vesicle-mediated transport [IGILink to PubMed article]
    Molecular Function: Rab GTPase activator activity [IGILink to PubMed article][IPILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLRSLFHTN QSSHDKDALT RGGYNAYLES LSRCDSGKAE EQKGKVISKL LEKKDVRALR  60
   61 YIGLGPLGFV NNSLRKDCWY ELLASQLLID DATEYITPVE KHKDEGQVIL DAERSFGGIV 120
  121 DKNLKLQLRK LLVELITRVL RKYPTLNYYQ GYHDIVSVFI MCFSWNVTKE NGLELENLSL 180
  181 QEEIDMERLF YCIEAFTLLY LRDFMMNSLD FSFEQLRVIS SLIKESNMKF YNLFKFDENE 240
  241 PLFAIGSILT IFAHNLKPID SGDNNLHKIL FQIFDMTISM QSMRLPLIIY KNLLLQNASE 300
  301 ISKQIEANSD FFENDFDLRH GAIQTVLQKK LYDEALWEEV LQITRKDATT ASKKALKRVS 360
  361 LNKYSALLNT ACGKPGCFDM STIIFYLSEQ TKMNEHYKEE KYHGVAARSK TRALVQRLGH 420
  421 FLPSKYNRWS KISLLIGIVA ILYQLRTTRS LSLVLNLRYM ISTKLKDLSH ININLHHVSH 480
  481 IWVDPIRDIL KLGHPTR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GYP8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..210]
    [272..311]    		 PSI-BLAST 37.0 Ypt/Rab-GAP domain of gyp1p
    2 View Details [211..271] PSI-BLAST 37.0 Ypt/Rab-GAP domain of gyp1p
    3 View Details [312..497] MSA 1.148993 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.76

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle