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View Structure Prediction Details

Protein: GYP8
Organism: Saccharomyces cerevisiae
Length: 497 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GYP8.

Description E-value Query
Range
Subject
Range
GYP8_YEAST - GTPase-activating protein GYP8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GYP8 PE=1...
GYP8 - GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate bu...
0.0 [1..497] [1..497]
gi|3093476 - gi|3093476|gb|AAC16031.1| EVI-5 homolog [Homo sapiens]
4.0E-72 [4..485] [115..553]
gi|6679707, gi|1... - gi|6679707|ref|NP_031990.1| ecotropic viral integration site 5 [Mus musculus], gi|1777919|gb|AAB4060...
2.0E-64 [4..485] [115..553]
gi|13874508 - gi|13874508|dbj|BAB46876.1| hypothetical protein [Macaca fascicularis]
4.0E-54 [6..346] [114..457]

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Predicted Domain #1
Region A:
Residues: [1-210]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLRSLFHTN QSSHDKDALT RGGYNAYLES LSRCDSGKAE EQKGKVISKL LEKKDVRALR  60
   61 YIGLGPLGFV NNSLRKDCWY ELLASQLLID DATEYITPVE KHKDEGQVIL DAERSFGGIV 120
  121 DKNLKLQLRK LLVELITRVL RKYPTLNYYQ GYHDIVSVFI MCFSWNVTKE NGLELENLSL 180
  181 QEEIDMERLF YCIEAFTLLY LRDFMMNSLD 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [272-311]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QIFDMTISMQ SMRLPLIIYK NLLLQNASEI SKQIEANSDF 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.0
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [211-271]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSFEQLRVIS SLIKESNMKF YNLFKFDENE PLFAIGSILT IFAHNLKPID SGDNNLHKIL  60
   61 F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.0
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [312-497]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FENDFDLRHG AIQTVLQKKL YDEALWEEVL QITRKDATTA SKKALKRVSL NKYSALLNTA  60
   61 CGKPGCFDMS TIIFYLSEQT KMNEHYKEEK YHGVAARSKT RALVQRLGHF LPSKYNRWSK 120
  121 ISLLIGIVAI LYQLRTTRSL SLVLNLRYMI STKLKDLSHI NINLHHVSHI WVDPIRDILK 180
  181 LGHPTR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle