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Protein Overview: BLM10

General Information:
Name(s) found: BLM10 / YFL007W [SGD]
Description(s) found:
Found 10 descriptions.
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  • Proteasome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1804 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    proteasome core complex [IDALink to PubMed article][IMPLink to PubMed article]
    proteasome complex [IDALink to PubMed article]
    Biological Process: protein catabolic process [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    proteasome assembly [IMPLink to PubMed article]
    Molecular Function: proteasome activator activity [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTANNDDDIK SPIPITNKTL SQLKRFERSP GRPSSSQGEI KRKKSRLYAA DGRPHSPLRA  60
   61 RSATPTLQDQ KLFNGMDSTS LLNERLQHYT LDYVSDRAQH MKNIYDPSSR WFSRSVRPEF 120
  121 PIEEFLPYKT ESHEDQAKYL CHVLVNLYIA ISSLDIQGLI SISSKDLADL KKEVDDLALK 180
  181 TDLFRLSNNT AENDLLGNDI ADYDDAEGLE DELDEYFDLA GPDFNATGKI TAKSATIVNV 240
  241 NHWTNELKNC LHFDFPVALR KSLATVYYYL SLVQGQKVYR QMHVDMFERL VSLDDDRTNF 300
  301 TELLQKQGLL LDHQIMLNFL CEFLPYPDPD YARYELSSKE DLQLFRLLLK HAHNAKPFFD 360
  361 KSKESLLVDT MNFLLSSLAP STMMAVMPIV TSVVPYHYHI HSKIIDYFPF CYSIWSSVSA 420
  421 NVAIDTHMYD FVGSISKDVH NKILSSEHEK DVVGVEFGEF GIFTDDQMTF MFNRLQGHLR 480
  481 TDGQIHSYSR TVKPFVYAIN GSKKDRFFEK LVSLAKAIET FIHPSNNGFW TKPNAKFVHA 540
  541 FIKSYHGRVK YEEDICARGV TNGICLTSFC HEEIVEIFLN IISLGSQNKN PDIANYYISC 600
  601 FAYLLELDPS NAYLIYDKIL IDLYDTLADQ FINSRHRIIS SLKQFTRVIR FIVMDKLYRV 660
  661 HITNVLSMLV SKLDMNDTNL TSNLINGIVS IAAFIPIQDL TGEDDYISFE SDTLPLVQQH 720
  721 FYHIKCGESS KTFRVDDELL NNAFKASTTV FQSMLKVYVE KIFQLVDVDL EDSLVTKINQ 780
  781 TTMILQESMD DKIFNYFASL LQRNFWSNDS FKEKDPNYEL VTIPLAALVR RNNGLSKELV 840
  841 RTLLFHIKEQ IKRGAGSVRS TSEIQQRDVK LVLYLTALND VLRQCHESLL EYSDELITFM 900
  901 KYLYDNVTNP PLDVITSIVI HSALATLCTT EITDCRLFPE DSKIPEKDRW GGLQFDPRRF 960
  961 DKQHLSFQWH VPSSDEITLS ISILESLSEY CINNVEELMK APRHDSEYGD MIQKYVLVMT1020
 1021 HTLSGSSLLF DPDFNKYRTQ SNLSYREKLI LLKNIRENNC DPQELDIDIE QIRSGKDDED1080
 1081 YIESKDIEAG LNAGVSDVVQ LRDEFPDELI VDEEVVSEMP SGVNTPIAGT HGTDNSAMSS1140
 1141 DLAFRDLDIY TCNYYFGNTT EEKLQNPQYL QVHRVRARIG HFFHKLYVFL STNFENNTNM1200
 1201 FQILLHGLKV WFTDLGQETV FNEDPNAFID VDFLENVQSL SHVNEPFTRT NFAIRANSLH1260
 1261 QSRVLLHSTN RKASKLENLL LVDIIQLATS LYPDIYKPAQ GTLVHCMKQL VGSYGVVINK1320
 1321 IIPSLEKAIK DHDYMKIQVI LNVLLIKKIH RKLMTDYKDI GRLIFLLIEC CRVNELEIGM1380
 1381 YADKILTDIV IGIKIPSSVC VISDQAFLPL APPDGTINLQ VEAVKLAKKK KREYYLSLLV1440
 1441 DLQDKLLDKL DNEKDMGWKI RMFILRFVTQ IQSNLESKPD KRAVFSIISQ ISTKHPEIIH1500
 1501 LVVKSLLSTC NKIISLSDYE YDITRAYKNE FNPSFVEILD TSTTSFPKTF TEEMNNFDNP1560
 1561 KYFIDLRAYV GWLCWGRLMY VMSPKALKLN LRENELEVLK TAGHLLTREF LRDVTMNLVQ1620
 1621 DNETRGVFSS GNVSFFSLVI LLISSGFCEL NMSDLFELCE SYYNKDDKAS MIMSVEIVAG1680
 1681 LVCGSKFMSV SDLDKRDTFI ENFLAKCLDY ELNHDAFEIW STLAWWLPAV VDLRRSKTFF1740
 1741 CHFINADGMF DRESDAATHQ TSKIYMLRSI LMSMEFRAPD VGKLFDELVF DHPYDQVRQL1800
 1801 SLNY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1804] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle