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Protein Overview: UBP5

General Information:
Name(s) found: UBP5 / YER144C [SGD]
Description(s) found:
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  • gi|731042|sp|P39944.1|UBP5_YEAST RecName: Full=Ubiquitin carboxyl-terminal hydrolase 5; AltName: Full=Ubiquitin thioesterase 5; AltName: Full=Ubiquitin-specific-processing protease 5; AltName: Full=Deubiquitinating enzyme 5 [NCBI NR]
  • gi|6320992|ref|NP_011071.1| Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck; Ubp5p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|603384|gb|AAB64671.1| Ubp5p: ubiquitin-specific protease [Saccharomyces cerevisiae] [NCBI NR]
  • gi|595377|gb|AAC48928.1| ubiquitin-specific protease [NCBI NR]
  • pir||S50277 ubiquitin-specific proteinase UBP5 (EC 3.4.-.-) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Ubiquitin carboxyl-terminal hydrolase 5 OS=Saccharomyces cerevisiae GN=UBP5 PE=1 SV=1 [Swiss-Prot]
  • UBP5 Ubiquitin-specific protease [mips]
  • Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck [SGD]
  • UBP5, Chr V from 457801-460218, reverse complement [yeast_orfs2]
  • Chr V from 457801-460218, reverse complement [yeastorf3.fasta]
  • Chr V from 460218-457801, reverse complement [yeastorf5.fasta]
  • (P39944) Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thiolesterase 5) (Ubiquitin-specific processing protease 5) (Deubiquitinating enzyme 5) [4932.FASTACCERV.txt]
  • UBP5 SGDID:S0000946, Chr V from 460218-457801, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Putative ubiquitin-specific protease that does not associate with the proteasome [Saccharomyces cerevisiae]gi|595377|gb|AAC48928.1| ubiquitin-specific proteasegi|603384|gb|AAB64671.1| Ubp5p: ubiquitin-specific protease [Saccharomyces cerevisiae]gi|1078 [nrdb_11152004_Chlamydomonas]
  • UBP5 SGDID:S000000946, Chr V from 460218-457801, reverse complement, Verified ORF, "Putative ubiquitin-specific protease that does not associate with the proteasome" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • UBP5 SGDID:S000000946, Chr V from 460218-457801, reverse complement, Verified ORF, "Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Ubiquitin carboxyl-terminal hydrolase 5 (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) [nr-271106-contam.fasta]
  • Ubp5p: ubiquitin-specific protease [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Putative ubiquitin-specific protease that does not associate with the proteasome; Ubp5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ubiquitin-specific protease [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Ubiquitin carboxyl-terminal hydrolase 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBP5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • UBP5 SGDID:S000000946, Chr V from 460223-457806, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck" [yeast-030211-contam.fasta]
  • UBP5 SGDID:S000000946, Chr V from 460223-457806, Genome Release 64-2-1, reverse complement, Verified ORF, "Putative ubiquitin-specific protease; concentrates at the bud neck; UBP5 has a paralog, DOA4, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YER144C SGDID:S000000946, Chr V from 460223-457806, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 805 amino acids

    Gene Ontology:
    Cellular Component: incipient cellular bud site [IDALink to PubMed article]
    cellular bud neck [IDALink to PubMed article]
    Biological Process: protein deubiquitination [TASLink to PubMed article]
    Molecular Function: ubiquitin-specific protease activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSEQALSEV VESAKERFGR LRHLVQKFLD DDDVPQECLP LLQECAEIWS SYVDACQDIT  60
   61 MQAPKEDANR LSKGFLRLNE TAFLYYMIVY TLLEDTLPRL KEFSSNKDQN VRNLYGERIQ 120
  121 LLHNDPNIER IRNVIENYPK FIQLQTIEPG KLSSMLHFHG DALLLIDVRP RSEFVRAHIK 180
  181 CKNIICIDPA SFKDSFTDQQ IESVSLITSP HSDITFFSNR DKFKFIILYT DTQLHNNFQQ 240
  241 RQTRILAKIL SQNSVIKPLS GTKILILENG FSNWVKLGGA YQSSVSETAH LTSSSSTPAF 300
  301 GSPQVPTGLF NQKSLSPNKD KSMPMVSMNT QPLLTTVQRP QLPLYYSDLP IIPQPSPNRN 360
  361 SPTVQKFSPH PPTTLSKLNT PSTIQNKANT VERISPDIRA AQAHAYLPPA SNVFSPRIPP 420
  421 LPQQNLSSSR QTILNNSQVL DLDLIVGLEN IGNCCYMNCI LQCLVGTHDL VRMFLDNTYL 480
  481 NFINFDSSRG SKGLLAKNFA ILVNNMHRHG AFTPPNVRTI PVQTIQFKKI CGHINPMYSD 540
  541 SMQQDCQEFC QFLLDGLHED LNQNGSKKHL KQLSDEEERM REKMSIRKAS ALEWERFLLT 600
  601 DFSAIIDLFQ GQYASRLQCQ VCEHTSTTYQ TFSVLSVPVP RVKTCNILDC FREFTKCERL 660
  661 GVDEQWSCPK CLKKQPSTKQ LKITRLPKKL IINLKRFDNQ MNKNNVFVQY PYSLDLTPYW 720
  721 ARDFNHEAIV NEDIPTRGQV PPFRYRLYGV ACHSGSLYGG HYTSYVYKGP KKGWYFFDDS 780
  781 LYRPITFSTE FITPSAYVLF YERIF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PUP1 UBP5 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..147] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [148..277] Pfam 21.055517 Rhodanese-like domain No confident structure predictions are available.
    3 View Details [278..488] ORFEUS 8.74 No description for 1ldvA was found.
    4 View Details [489..540] deduced N/A No confident structure predictions are available.
    5 View Details [541..670] MSA 2.23399 View MSA. No confident structure predictions are available.
    6 View Details [671..739] MSA 3.203994 View MSA. Confident ab initio structure predictions are available.
    7 View Details [740..805] Pfam 27.113509 Ubiquitin carboxyl-terminal hydrolase No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.7573477158791 bayes_pls_golite062009
  • protein binding
    		•  1.56261884445895 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  0.711045884031031 bayes_pls_golite062009
  • catalytic activity
    		•  0.660280721417663 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  0.514129714366787 bayes_pls_golite062009
  • transferase activity
    		•  0.24413644201982 bayes_pls_golite062009
  • phosphatase activity
    		•  0.0126182055752568 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle