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View Structure Prediction Details

Protein: UBP5
Organism: Saccharomyces cerevisiae
Length: 805 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UBP5.

Description E-value Query
Range
Subject
Range
UBP5_YEAST - Ubiquitin carboxyl-terminal hydrolase 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
UBP5 - Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concen...
0.0 [1..805] [1..805]
UBP4_KLULA - Ubiquitin carboxyl-terminal hydrolase 4 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 7...
UBP4_KLULA - Ubiquitin carboxyl-terminal hydrolase 4 OS=Kluyveromyces lactis GN=DOA4 PE=3 SV=1
0.0 [20..804] [15..794]
gi|6492126, gi|5... - gi|6492126|gb|AAF14190.1|AF106659_1 deubiquitinating enzyme Ubp69 [Rattus norvegicus], gi|51592088|r...
9.0E-96 [268..802] [104..610]
UBP21_MOUSE - Ubiquitin carboxyl-terminal hydrolase 21 OS=Mus musculus GN=Usp21 PE=1 SV=1
4.0E-94 [275..802] [66..557]
gi|16552833, gi|... - gi|21361712|ref|NP_004196.3| ubiquitin specific peptidase 2 isoform a [Homo sapiens], gi|16552833|db...
2.0E-90 [267..802] [103..597]

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Predicted Domain #1
Region A:
Residues: [1-147]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSEQALSEV VESAKERFGR LRHLVQKFLD DDDVPQECLP LLQECAEIWS SYVDACQDIT  60
   61 MQAPKEDANR LSKGFLRLNE TAFLYYMIVY TLLEDTLPRL KEFSSNKDQN VRNLYGERIQ 120
  121 LLHNDPNIER IRNVIENYPK FIQLQTI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.977 0.069 protein deubiquitination a.24.9 alpha-catenin/vinculin

Predicted Domain #2
Region A:
Residues: [148-277]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPGKLSSMLH FHGDALLLID VRPRSEFVRA HIKCKNIICI DPASFKDSFT DQQIESVSLI  60
   61 TSPHSDITFF SNRDKFKFII LYTDTQLHNN FQQRQTRILA KILSQNSVIK PLSGTKILIL 120
  121 ENGFSNWVKL 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 21.055517
Match: PF00581
Description: Rhodanese-like domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.7573477158791 bayes_pls_golite062009
protein binding 1.56261884445895 bayes_pls_golite062009
protein tyrosine phosphatase activity 0.711045884031031 bayes_pls_golite062009
catalytic activity 0.660280721417663 bayes_pls_golite062009
phosphoprotein phosphatase activity 0.514129714366787 bayes_pls_golite062009
transferase activity 0.24413644201982 bayes_pls_golite062009
phosphatase activity 0.0126182055752568 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [278-488]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGAYQSSVSE TAHLTSSSST PAFGSPQVPT GLFNQKSLSP NKDKSMPMVS MNTQPLLTTV  60
   61 QRPQLPLYYS DLPIIPQPSP NRNSPTVQKF SPHPPTTLSK LNTPSTIQNK ANTVERISPD 120
  121 IRAAQAHAYL PPASNVFSPR IPPLPQQNLS SSRQTILNNS QVLDLDLIVG LENIGNCCYM 180
  181 NCILQCLVGT HDLVRMFLDN TYLNFINFDS S

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.74
Match: 1ldvA
Description: No description for 1ldvA was found.

Predicted Domain #4
Region A:
Residues: [489-540]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGSKGLLAKN FAILVNNMHR HGAFTPPNVR TIPVQTIQFK KICGHINPMY SD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [541-670]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SMQQDCQEFC QFLLDGLHED LNQNGSKKHL KQLSDEEERM REKMSIRKAS ALEWERFLLT  60
   61 DFSAIIDLFQ GQYASRLQCQ VCEHTSTTYQ TFSVLSVPVP RVKTCNILDC FREFTKCERL 120
  121 GVDEQWSCPK 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [671-739]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CLKKQPSTKQ LKITRLPKKL IINLKRFDNQ MNKNNVFVQY PYSLDLTPYW ARDFNHEAIV  60
   61 NEDIPTRGQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.873 0.066 protein deubiquitination b.84.2 Rudiment single hybrid motif

Predicted Domain #7
Region A:
Residues: [740-805]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPPFRYRLYG VACHSGSLYG GHYTSYVYKG PKKGWYFFDD SLYRPITFST EFITPSAYVL  60
   61 FYERIF

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 27.113509
Match: PF00443
Description: Ubiquitin carboxyl-terminal hydrolase

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle