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Protein Overview: AIM10

General Information:
Name(s) found: AIM10 / YER087W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 576 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: proline-tRNA ligase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKYRTLSRS CHIFHPKSLS NNTLKSETTQ ELLQTVGFVR RSQVGLFQWL PLGLRSLNKV  60
   61 SNAIRNRMDS DGGAIEVSLS AISSKALWQA TDRWNNSELF KLKDSKGKQY CLTATCEEDI 120
  121 TDLMKNYIAS YKDMPITIYQ MTRKYRDEIR PRGGILRGRE FLMKDAYSFA SNEEDAFASF 180
  181 QKLDDTYNKI FKDLKIPFVS AWADSGDIGG EFSKEFHLIH ESGEDTLMSC KHCGDISTLD 240
  241 MSQSYPEKDG QYSGDVDCKY ALTKDHSTLI CFYYPKDRQL NWNLALNAMD KDIDLTLRNK 300
  301 PNDHVLQVYE KDNEDIMFSK ILRVMDCRLN SKSNFPDFPL KKYLKNNFGQ ISDVSIVDAQ 360
  361 ENEICGKCEE GRLEPLKSIE VGHIFLLGNK YSKPLNVKFV DKENKNETFV HMGCYGIGVS 420
  421 RLVGAIAELG RDSNGFRWPA IMAPYKVSIC TGPNNPENSQ RLQDVKSELL NDPTMQNLQN 480
  481 DILDQFNEKL GIGARIKLSH AMGIPLCVIV GSKSWPNVEI EVRGIRWGEK DLWRKQFEKR 540
  541 CSELQWKCTK NEHGIEKHTV PIQHLAEVIG VLLKDM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..187] PSI-BLAST 109.39794 Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)
    2 View Details [188..437] PSI-BLAST 102.69897 Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS)
    3 View Details [438..576] PSI-BLAST 102.69897 Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle