YRC Public Data Repository - Protein Structure Prediction

Protein:	AIM10
Organism:	Saccharomyces cerevisiae
Length:	576 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AIM10.

Description	E-value	Query Range	Subject Range
gi\|189364925, gi... - gi\|189364925\|gb\|EDU83341.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4501], gi\|168765... gi\|13359652, gi\|... - gi\|15829450\|ref\|NP_308223.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. Sakai], gi\|133596... gi\|188013912, gi... - gi\|188013912\|gb\|EDU52034.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4113], gi\|168752... gi\|25293208, gi\|... - pir\|\|D85504 proline tRNA synthetase [imported] - Escherichia coli (strain O157:H7, substrain EDL933... gi\|189371068, gi... - gi\|189371068\|gb\|EDU89484.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC869], gi\|1687893... gi\|168782925, gi... - gi\|188999651\|gb\|EDU68637.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4076], gi\|168782... gi\|12512925, gi\|... - gi\|15799876\|ref\|NP_285888.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 EDL933], gi\|12512925\|g... gi\|187767123, gi... - gi\|187767123\|gb\|EDU30967.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4196], gi\|168777... SYP_ECO57 - Proline--tRNA ligase OS=Escherichia coli O157:H7 GN=proS PE=3 SV=1 gi\|189361055, gi... - gi\|189361055\|gb\|EDU79474.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4486], gi\|168769... gi\|208812619, gi... - gi\|208812619\|ref\|ZP_03253948.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4045], gi\|20... gi\|208729249, gi... - gi\|208809448\|ref\|ZP_03251785.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4206], gi\|20... gi\|195939891 - gi\|195939891\|ref\|ZP_03085273.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4024] gi\|168802460, gi... - gi\|189375548\|gb\|EDU93964.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC508], gi\|1688024... gi\|254590727, gi... - gi\|254791327\|ref\|YP_003076164.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. TW14359], gi\|... gi\|217320535, gi... - gi\|217324314\|ref\|ZP_03440398.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. TW14588], gi\|2... SYP_ECO5E - Proline--tRNA ligase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=proS PE=3 SV=1 gi\|208741291, gi... - gi\|208821168\|ref\|ZP_03261488.1\| prolyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4042], gi\|20...	0.0	[8..549]	[1..571]
SYP_ECOLI - Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase) (ProRS) (Global RNA synthesis factor) - ... SYP_ECOBW - Proline--tRNA ligase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=proS PE=3 SV=1 EG10770 - prolyl-tRNA synthetase / Proline--tRNA ligase gi\|85674379, gi\|... - gi\|89107075\|ref\|AP_000855.1\| prolyl-tRNA synthetase [Escherichia coli str. K-12 substr. W3110], gi\|8... SYP_ECODH - Proline--tRNA ligase OS=Escherichia coli (strain K12 / DH10B) GN=proS PE=3 SV=1 EG10770 - prolyl-tRNA synthetase / Proline--tRNA ligase	0.0	[8..549]	[1..571]
SYP_YERPE - Proline--tRNA ligase OS=Yersinia pestis GN=proS PE=3 SV=1 gi\|149366930, gi... - gi\|149366930\|ref\|ZP_01888963.1\| prolyl-tRNA synthetase [Yersinia pestis CA88-4125], gi\|149290544\|gb\|... gi\|45442549, gi\|... - gi\|45442549\|ref\|NP_994088.1\| prolyl-tRNA synthetase [Yersinia pestis biovar Microtus str. 91001], gi... gi\|22126985, gi\|... - gi\|22126985\|ref\|NP_670408.1\| prolyl-tRNA synthetase [Yersinia pestis KIM], gi\|21960030\|gb\|AAM86659.1... SYP_YERPA - Proline--tRNA ligase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=proS PE=3 SV=1 gi\|15979136, gi\|... - gi\|218928237\|ref\|YP_002346112.1\| prolyl-tRNA synthetase [Yersinia pestis CO92], gi\|16121369\|ref\|NP_4... SYP_YERPN - Proline--tRNA ligase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=proS PE=3 SV=1 SYP_YERPG - Proline--tRNA ligase OS=Yersinia pestis bv. Antiqua (strain Angola) GN=proS PE=3 SV=1 gi\|166011913, gi... - gi\|166011913\|ref\|ZP_02232811.1\| prolyl-tRNA synthetase [Yersinia pestis biovar Antiqua str. E1979001... gi\|165920968, gi... - gi\|165927072\|ref\|ZP_02222904.1\| prolyl-tRNA synthetase [Yersinia pestis biovar Orientalis str. F1991... gi\|167400131, gi... - gi\|167400131\|ref\|ZP_02305649.1\| prolyl-tRNA synthetase [Yersinia pestis biovar Antiqua str. UG05-045... gi\|166207102, gi... - gi\|166211331\|ref\|ZP_02237366.1\| prolyl-tRNA synthetase [Yersinia pestis biovar Antiqua str. B4200300... gi\|167055724, gi... - gi\|167425324\|ref\|ZP_02317077.1\| prolyl-tRNA synthetase [Yersinia pestis biovar Mediaevalis str. K197... gi\|167419446, gi... - gi\|167419446\|ref\|ZP_02311199.1\| prolyl-tRNA synthetase [Yersinia pestis biovar Orientalis str. MG05-... gi\|167470133 - gi\|167470133\|ref\|ZP_02334837.1\| prolyl-tRNA synthetase [Yersinia pestis FV-1] gi\|229837776, gi... - gi\|229837776\|ref\|ZP_04457936.1\| prolyl-tRNA synthetase [Yersinia pestis Pestoides A], gi\|229704153\|g... gi\|229840998, gi... - gi\|229840998\|ref\|ZP_04461157.1\| prolyl-tRNA synthetase [Yersinia pestis biovar Orientalis str. PEXU2... gi\|229843099, gi... - gi\|229843099\|ref\|ZP_04463249.1\| prolyl-tRNA synthetase [Yersinia pestis biovar Orientalis str. India... gi\|89105159, gi\|... - gi\|89105159\|ref\|ZP_01177684.1\| COG0442: Prolyl-tRNA synthetase [Yersinia pestis biovar Orientalis st...	0.0	[8..550]	[1..572]
SYP_ECOLI - Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase) (ProRS) (Global RNA synthesis factor) - ... SYP_ECOBW - Proline--tRNA ligase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=proS PE=3 SV=1 EG10770 - prolyl-tRNA synthetase / Proline--tRNA ligase gi\|85674379, gi\|... - gi\|89107075\|ref\|AP_000855.1\| prolyl-tRNA synthetase [Escherichia coli str. K-12 substr. W3110], gi\|8... SYP_ECODH - Proline--tRNA ligase OS=Escherichia coli (strain K12 / DH10B) GN=proS PE=3 SV=1 EG10770 - prolyl-tRNA synthetase / Proline--tRNA ligase	0.0	[8..549]	[1..571]
gi\|16759234 - gi\|16759234\|ref\|NP_454851.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Typ... SYP_SALPA - Proline--tRNA ligase OS=Salmonella paratyphi A GN=proS PE=3 SV=1 SYP_SALTI - Prolyl-tRNA synthetase OS=Salmonella typhi GN=proS PE=3 SV=1 SYP_SALTY - Prolyl-tRNA synthetase OS=Salmonella typhimurium GN=proS PE=3 SV=1 SYP_SALPB - Proline--tRNA ligase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=proS PE=3 SV=1 SYP_SALPA - Proline--tRNA ligase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=proS PE=3 SV=1 SYP_SALTY - Proline--tRNA ligase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=proS PE=3 SV... gi\|29140783, gi\|... - gi\|29140783\|ref\|NP_804125.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Typ... SYP_SALTI - Proline--tRNA ligase OS=Salmonella typhi GN=proS PE=3 SV=1 SYP_SALEP - Proline--tRNA ligase OS=Salmonella enteritidis PT4 (strain P125109) GN=proS PE=3 SV=1 SYP_SALG2 - Proline--tRNA ligase OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=proS PE=3 SV=1 gi\|213428490 - gi\|213428490\|ref\|ZP_03361240.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar ... gi\|213051828 - gi\|213051828\|ref\|ZP_03344706.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar ... SYP_SALPK - Proline--tRNA ligase OS=Salmonella paratyphi A (strain AKU_12601) GN=proS PE=3 SV=1 gi\|197264294, gi... - gi\|197264294\|ref\|ZP_03164368.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar ... gi\|200386929, gi... - gi\|200386929\|ref\|ZP_03213541.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar ... SYP_SALDC - Proline--tRNA ligase OS=Salmonella dublin (strain CT_02021853) GN=proS PE=3 SV=1 gi\|195632930, gi... - gi\|195632930\|gb\|EDX51384.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Newp... gi\|205346928, gi... - gi\|205346928\|gb\|EDZ33559.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Hada... gi\|194459187, gi... - gi\|194472823\|ref\|ZP_03078807.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar ... SYP_SALHS - Proline--tRNA ligase OS=Salmonella heidelberg (strain SL476) GN=proS PE=3 SV=1 gi\|167990131, gi... - gi\|205331403\|gb\|EDZ18167.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar 4,[5... gi\|168245012, gi... - gi\|205336220\|gb\|EDZ22984.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Heid... gi\|205335202, gi... - gi\|205335202\|gb\|EDZ21966.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar Kent... lcl\|NC_016856.1_... - [gene=proS] [protein=prolyl-tRNA synthetase] [protein_id=YP_005235913.1] [location=complement(283167... gi\|213865222 - gi\|213865222\|ref\|ZP_03387341.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar ... SYP_SALPB - Prolyl-tRNA synthetase OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=proS PE=3 SV=1 gi\|213580835 - gi\|213580835\|ref\|ZP_03362661.1\| prolyl-tRNA synthetase [Salmonella enterica subsp. enterica serovar ... SYP_SALTY - Proline--tRNA ligase OS=Salmonella typhimurium GN=proS PE=3 SV=1	0.0	[8..549]	[1..571]
gi\|107100413 - gi\|107100413\|ref\|ZP_01364331.1\| hypothetical protein PaerPA_01001438 [Pseudomonas aeruginosa PACS2] SYP_PSEA8 - Proline--tRNA ligase OS=Pseudomonas aeruginosa (strain LESB58) GN=proS PE=3 SV=1 SYP_PSEAE - Proline--tRNA ligase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)... SYP_PSEAE - Prolyl-tRNA synthetase OS=Pseudomonas aeruginosa GN=proS PE=3 SV=1	0.0	[8..550]	[1..571]
AIM10 - Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria... SYPM_YEAST - Probable proline--tRNA ligase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c...	0.0	[1..576]	[1..576]
SYP_HAEIN - Prolyl-tRNA synthetase OS=Haemophilus influenzae GN=proS PE=1 SV=1 SYP_HAEIN - Proline--tRNA ligase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN=proS P...	0.0	[8..548]	[1..569]
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	0.0	[8..549]	[1..571]

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Predicted Domain #1

Region A:
Residues: [1-187]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKYRTLSRS CHIFHPKSLS NNTLKSETTQ ELLQTVGFVR RSQVGLFQWL PLGLRSLNKV  60
   61 SNAIRNRMDS DGGAIEVSLS AISSKALWQA TDRWNNSELF KLKDSKGKQY CLTATCEEDI 120
  121 TDLMKNYIAS YKDMPITIYQ MTRKYRDEIR PRGGILRGRE FLMKDAYSFA SNEEDAFASF 180
  181 QKLDDTY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	109.39794
Match:	1qf6A_
Description:	Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [188-437]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKIFKDLKIP FVSAWADSGD IGGEFSKEFH LIHESGEDTL MSCKHCGDIS TLDMSQSYPE  60
   61 KDGQYSGDVD CKYALTKDHS TLICFYYPKD RQLNWNLALN AMDKDIDLTL RNKPNDHVLQ 120
  121 VYEKDNEDIM FSKILRVMDC RLNSKSNFPD FPLKKYLKNN FGQISDVSIV DAQENEICGK 180
  181 CEEGRLEPLK SIEVGHIFLL GNKYSKPLNV KFVDKENKNE TFVHMGCYGI GVSRLVGAIA 240
  241 ELGRDSNGFR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	102.69897
Match:	1evkA_
Description:	Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [438-576]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WPAIMAPYKV SICTGPNNPE NSQRLQDVKS ELLNDPTMQN LQNDILDQFN EKLGIGARIK  60
   61 LSHAMGIPLC VIVGSKSWPN VEIEVRGIRW GEKDLWRKQF EKRCSELQWK CTKNEHGIEK 120
  121 HTVPIQHLAE VIGVLLKDM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	102.69897
Match:	1evkA_
Description:	Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits