Protein Overview: YAT2

General Information:
Name(s) found:	YAT2 / YER024W [SGD]
Description(s) found: Found 22 descriptions. SHOW ALL	Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane [SGD]
Organism:	Saccharomyces cerevisiae
Length:	923 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	alcohol metabolic process [IGI][IMP] carnitine metabolic process [IMP]
Molecular Function:	carnitine O-acetyltransferase activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSGSTIVSS DKSGRTFKHE EELPKLPLPK LCDTLQRLKE SLEPLYYADG YYQHPLDPEQ  60
   61 IEKLSSIIRD FEENPVSEKL QSKLQSYHDT RDCYLDELHL DINNQTSTRE IQDDVLPRNP 120
  121 FLVLADDALP NITQADRSAV LVHSAARFIS ALKQDLLPPD INATNGKPLS MAPFLNLFGT 180
  181 TRSPVFQRGE VENFDLNKPY TASDLEDPDY SSDEDDNDEP TQKDFDDRKR KHEEDIFTGN 240
  241 GITIKRHPDS KHILIISRGQ YYTLEVLDST NKIIYTAAEL TTIFNHIIKD SSGIEKSTAL 300
  301 GSLTSHSFRN WKYARKRLQK RYPNELHRID SALFVLVLDE SQEETTNDGD DTADISQMFN 360
  361 RTITERDKKC TSANCKRVFY GTSIINSKGH QVGSCVSRWY DKLQLVVTAD AKATVIWDSF 420
  421 TCDGSVVLRF TSEIYTESVL RLARDVNAGD PQFSLWPNVT QMDPETKKLM TATISADGGG 480
  481 PSEIDPKLVV NKIDWSFSNI LNTHVHLSET KLADLISKYD IVRASIPLGR RSAQRLGVKP 540
  541 DSMVQVALQI AHYALYGRMV FGLEPVSTRG FKNSRSSFIN IQSQALLELC QLFISSSIDG 600
  601 TDKLDKFIQT CETHNNMVKH AKSGVGYEKH FNALKYLFKF HDHFGIHLSG DESSAAKDLF 660
  661 ENPLVLPFSQ PELIVANCGN AATTTFGITP AVPHGFGIGY IIKDDQVDLT VTSQFRQGDR 720
  721 LMFMLSWVLG EIRSYWRMSR GTSHNKTGVK ISPVVDKLYE MDNAVNNPPK RNGHTVNGSR 780
  781 KTSSSSQVNL NRYGGFFDLE GHIDSRNISK TPSMKNLQKT FNGLTMSADN DHSSSAVSVP 840
  841 TEKEKLNTGH EILQIQPREV ASNGLEADDE TDIEIVAGNA DGTSSSASSA TSLNSKKRNV 900
  901 INSRFDIDFD RSRVGRKVAT LDQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	HXK2	YAT2	1	Unpublished Fields Lab Data
View Screen	YJR056C	YAT2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	YAT2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..780]	Pfam	245.455932	Choline/Carnitine o-acyltransferase No confident structure predictions are available.
2	View Details	[781..923]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
carnitine O-acyltransferase activity	7.54616819269984	bayes_pls_golite062009
carnitine O-acetyltransferase activity	7.38318207912192	bayes_pls_golite062009
choline O-acetyltransferase activity	6.09272417016149	bayes_pls_golite062009
octanoyltransferase activity	4.52268776339565	bayes_pls_golite062009
O-octanoyltransferase activity	4.52268776339565	bayes_pls_golite062009
carnitine O-octanoyltransferase activity	4.52268776339565	bayes_pls_golite062009
carnitine O-palmitoyltransferase activity	3.83467723502092	bayes_pls_golite062009
O-palmitoyltransferase activity	3.83467723502092	bayes_pls_golite062009
transferase activity, transferring acyl groups	3.7327637835604	bayes_pls_golite062009
O-acyltransferase activity	3.7101056995294	bayes_pls_golite062009
acyltransferase activity	3.08588280042054	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	3.027770031317	bayes_pls_golite062009
S-acyltransferase activity	2.74258684113582	bayes_pls_golite062009
O-acetyltransferase activity	2.37098434941789	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	2.20915191604487	bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity	2.0783127648124	bayes_pls_golite062009
S-acetyltransferase activity	2.04797137596259	bayes_pls_golite062009
transferase activity	1.78692523095641	bayes_pls_golite062009
choline binding	1.59193088660278	bayes_pls_golite062009
catalytic activity	1.51562638409295	bayes_pls_golite062009
succinyltransferase activity	1.48650517081097	bayes_pls_golite062009
acetyltransferase activity	1.12787027896966	bayes_pls_golite062009
S-succinyltransferase activity	1.03771162623809	bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity	1.03771162623809	bayes_pls_golite062009
binding	0.999555841397607	bayes_pls_golite062009
palmitoyltransferase activity	0.607756896737891	bayes_pls_golite062009
protein binding	0.104367069798378	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2