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Protein Overview: NPR2

General Information:
Name(s) found: NPR2 / YEL062W [SGD]
Description(s) found:
Found 17 descriptions.
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  • Component of an evolutionarily conserved Npr2/3 complex that mediates downregulation of TORC1 activity in response to amino acid limitation; homolog of human NPRL2; target of Grr1p (E3 ligase); required for growth on urea and proline [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 624 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: urea transport [IMPLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    proline transport [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRSSGQRQM LSYFQGFVPI HTIFYSVFHP TEGSKIKYEF PPNNLKNHGI NFNTFKNYII  60
   61 PKPILCHKLI TFKYGTYRIV CYPVTINSPI YARNFFSFNF VFVFPYDCET SPYEPAITRL 120
  121 GKMFKVLEEQ NQLLSKSERD PVFFDLKVLE NSTTTPSTAG PSSTPNPSSN TTPTHPTSEK 180
  181 DTKDMRSSRY SDLIKDLGLP QSAFSIQDLL MRIFQDLNNY SECLIPIDEG NAVDIKIFPL 240
  241 LRPPTTCVSL EDVPLSSVNL KKIIDVNWDP TMMSIVPYID GLNSIAKISK LSNSDPGLVI 300
  301 ECIRHLIYYK CVTLSDIFQF SNIYAPSSLI RNFLTDPLMA SDCQSYVTFP EVSKISNLPL 360
  361 NKSLGSGDQD SPSFSVRRKS KSSSIPSNPD SRTTSFSSTS RVSQNSSLNS SFSSIYKDWR 420
  421 QSQTSCSSSN IHVINNRNRF LPTRSCLFDL YRSLSQGQTL KTWYESKYMI LKENNIDIRR 480
  481 FITFGLEKRI IYRCYSFPVM INAGSREPKE MTPIITKDLV NNDKLLEKRN HNHLLSATGS 540
  541 RNTAQSGNLK PERPSKVSFE MQRVSSLATG KSTMPKLSDE EEGILEESIR NAETFDKICV 600
  601 LLSKPKLEVE SYLNELGEFK VINS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR2 No Comments Reinke A, et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..378] MSA 5.013932 View MSA. No confident structure predictions are available.
    2 View Details [379..624] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.56

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle