Protein Overview: PFA5

General Information:
Name(s) found:	PFA5 / YDR459C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|927749\|gb\|AAB64921.1\| Ydr459cp; CAI: 0.12 [Saccharomyces cerevisiae] [NCBI NR] gi\|74627180\|sp\|Q03289.1\|PFA5_YEAST RecName: Full=Palmitoyltransferase PFA5; AltName: Full=Protein fatty acyltransferase 5 [NCBI NR] gi\|6320667\|ref\|NP_010747.1\| Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; Pfa5p [Saccharomy [NCBI NR] pir\|\|S69627 hypothetical protein YDR459c - yeast (Saccharomyces cerevisiae) [NCBI NR] Palmitoyltransferase PFA5 OS=Saccharomyces cerevisiae GN=PFA5 PE=1 SV=1 [Swiss-Prot] PFA5 Palmitoyltransferase [mips] Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain [SGD] YDR459C, Chr IV from 1382308-1383432, reverse complement [yeast_orfs2] Chr IV from 1382308-1383432, reverse complement [yeastorf3.fasta] Chr IV from 1382307-1383431, reverse complement [yeastorf4.fasta] Chr IV from 1383431-1382307, reverse complement [yeastorf5.fasta] >Q03289 (Q03289) D8035.3P [4932.FASTACCERV.txt] YDR459C SGDID:S0002867, Chr IV from 1383431-1382307, reverse complement, Uncharacterized ORF [yeastflysequest.fasta] YDR459C SGDID:S0002867, Chr IV from 1383433-1382309, reverse complement, Uncharacterized ORF [10112005cervSGD.fasta] Ydr459cp; CAI: 0.12 [Saccharomyces cerevisiae]gi\|6320667\|ref\|NP_010747.1\| Ydr459cp [Saccharomyces cerevisiae]gi\|2131507\|pir\|\|S69627 hypothetical protein YDR459c - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas] (Q03289) Ydr459cp [cerv4932.FASTAC] YDR459C SGDID:S000002867, Chr IV from 1383433-1382309, reverse complement, Verified ORF, "Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp- [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] PFA5 SGDID:S000002867, Chr IV from 1383435-1382311, reverse complement, Verified ORF, "Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His [yeast-contam.fasta] PFA5 SGDID:S000002867, Chr IV from 1383436-1382312, reverse complement, Verified ORF, "Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; Pfa5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Ydr459cp; CAI: 0.12 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Palmitoyltransferase PFA5 (Protein fatty acyltransferase 5) [nr-271106-contam.fasta] PFA5 SGDID:S000002867, Chr IV from 1383436-1382312, reverse complement, Verified ORF, "Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain" [yeast-bovrabprots.fasta] PFA5 SGDID:S000002867, Chr IV from 1383435-1382311, reverse complement, Verified ORF, "Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain" [yeast-contam_custom.fasta] [chemostatdb.fasta] Palmitoyltransferase PFA5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PFA5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] PFA5 SGDID:S000002867, Chr IV from 1383443-1382319, Genome Release 64-1-1, reverse complement, Verified ORF, "Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain" [yeast-030211-contam.fasta] PFA5 SGDID:S000002867, Chr IV from 1383443-1382319, Genome Release 64-2-1, reverse complement, Verified ORF, "Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain" [20141208_orf_trans.fasta] TR7699\|c0_g1_i1\|g.5346 ORF TR7699\|c0_g1_i1\|g.5346 TR7699\|c0_g1_i1\|m.5346 type:complete len:375 (+) TR7699\|c0_g1_i1:115-1239(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] YDR459C SGDID:S000002867, Chr IV from 1383443-1382319, Genome Release 64-1-1, reverse complement, Verified ORF, "Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_515\|g.157 ORF asmbl_515\|g.157 asmbl_515\|m.157 type:complete len:375 (+) asmbl_515:115-1239(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_517\|g.676 ORF ID=asmbl_517\|g.676 ID=asmbl_517\|m.676 type:complete len:375 (+) ID=asmbl_517:115-1239(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	374 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	protein amino acid palmitoylation [ISS ]
Molecular Function:	protein-cysteine S-palmitoleyltransferase activity [IDA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALSWNIRIR RRSWFRFILP IIVLGLLCYG TWAYCHKLCY EQVDKRLRQK SVSVGLICAV  60
   61 CFLDVVVIFI WLQIVILVGP GTQPHVAPFL ILPIASEEKT SNTSQNTSVE YDAVVPPKCY 120
  121 QSDPHGYPIW CSECQSLKME RTHHSSELGH CIPRFDHYCM WIGTVIGRDN YRLFVQFAAY 180
  181 FSTLLLIMWV SICVYIRIIT QHNHNYSPNL NANIISTLVF AILGWLLTAS LLASSIFYMS 240
  241 QNKTSLEAII DSKRKKFGTR KIFCYYSEAN KLRFVVEFDR SEFHSFWDKK SILANIKDFM 300
  301 GSNILMWIIP LGKPYTSRCK SDGKSGSKTT LVEILGPYEE TLSDYTIQAI EDKISRGEYL 360
  361 ATLRASGDDS DPAY

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RAD6	PFA5	1	Unpublished Fields Lab Data
View Screen	UBC7	PFA5	1	Unpublished Fields Lab Data
View Screen	CTF13	PFA5	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..101]	deduced	N/A	Confident ab initio structure predictions are available.
2	View Details	[102..207]	Pfam	33.420216	DHHC zinc finger domain No confident structure predictions are available.
3	View Details	[208..374]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2