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Protein Overview: LSM6

General Information:
Name(s) found: LSM6 / YDR378C [SGD]
Description(s) found:
Found 17 descriptions.
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  • Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 123 amino acids

    Gene Ontology:
    Cellular Component: U4/U6 x U5 tri-snRNP complex [IDALink to PubMed article][IPILink to PubMed article]
    nucleolus [IDALink to PubMed article]
    U6 snRNP [IDALink to PubMed articleLink to PubMed article][TASLink to PubMed article]
    small nucleolar ribonucleoprotein complex [IPILink to PubMed article]
    Biological Process: mRNA catabolic process [TASLink to PubMed article]
    nuclear mRNA splicing, via spliceosome [IPILink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNKQRRSNP FNNAQDAILT RKYGIAQYKQ NKQRLLVMSG KASTEGSVTT EFLSDIIGKT  60
   61 VNVKLASGLL YSGRLESIDG FMNVALSSAT EHYESNNNKL LNKFNSDVFL RGTQVMYISE 120
  121 QKI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen LSM8 LSM6 2 Uetz P, et al. (2000)
    View Screen LSM2 LSM6 2 Uetz P, et al. (2000)
    View Screen LSM4 LSM6 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..123] PSI-BLAST 18.045757 Archaeal homoheptameric Sm protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
    		• 9.36615441177233 bayes_pls_golite062009
  • RNA binding
    		•  5.81718051012035 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.69031444148163 bayes_pls_golite062009
  • mRNA binding
    		•  2.57166143288861 bayes_pls_golite062009
  • binding
    		•  2.04681172391952 bayes_pls_golite062009
  • protein binding
    		•  0.402136856098527 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle