Protein Overview: ATP22

General Information:
Name(s) found:	ATP22 / YDR350C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|849179\|gb\|AAB64786.1\| Tcm10p [Saccharomyces cerevisiae] [NCBI NR] gi\|6320557\|ref\|NP_010637.1\| Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; Atp22p [Saccharomyces cerevis [NCBI NR] pir\|\|S61147 TCM10 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] TCM10 Protein functions at a post-translational stage in assembly of F0 subunit of mitochondrial ATPase [mips] Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane [SGD] TCM10, Chr IV from 1176328-1178163, reverse complement [yeast_orfs2] Chr IV from 1176328-1178163, reverse complement [yeastorf3.fasta] Chr IV from 1176327-1178162, reverse complement [yeastorf4.fasta] Chr IV from 1178162-1176327, reverse complement [yeastorf5.fasta] TCM10 SGDID:S0002758, Chr IV from 1178163-1176328, reverse complement, Verified ORF [yeastflysequest.fasta] TCM10 SGDID:S0002758, Chr IV from 1178165-1176330, reverse complement, Verified ORF [10112005cervSGD.fasta] Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis [Saccharomyces cerevisiae]gi\|2133174\|pir\|\|S61147 TCM10 pr [nrdb_11152004_Chlamydomonas] TCM10 SGDID:S000002758, Chr IV from 1178165-1176330, reverse complement, Verified ORF, "Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme compl [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] TCM10 SGDID:S000002758, Chr IV from 1178167-1176332, reverse complement, Verified ORF, "Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme compl [yeast-contam.fasta] ATP22 SGDID:S000002758, Chr IV from 1178168-1176333, reverse complement, Verified ORF, "Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme compl [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Tcm10p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; Tcm10p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ATP22 SGDID:S000002758, Chr IV from 1178168-1176333, reverse complement, Verified ORF, "Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis" [yeast-bovrabprots.fasta] TCM10 SGDID:S000002758, Chr IV from 1178167-1176332, reverse complement, Verified ORF, "Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis" [yeast-contam_custom.fasta] [chemostatdb.fasta]
Organism:	Saccharomyces cerevisiae
Length:	611 amino acids
Gene Ontology:
Cellular Component:	mitochondrial inner membrane [IDA]
Biological Process:	protein complex assembly [IDA][IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKCICRVYS QPLAQMVTSP LFKHMGSAGT YTILPITNLR HLSTKNCPLK IKSNRSEPLQ  60
   61 FGDFERQVPC SRKSGSSKNV QKRLYELRQL KTVLSETFGV TEYASFFESL RNALHINNCS 120
  121 ENEKKKLLYD IILHQHELYP EVARKIGFYL PGEVHRWFWY HIPKSESFNH YLFLLKSDVL 180
  181 LFTSNYCTRF TNRLIKGTEM ERQLATFQIF LHDETNIKFI MEKVLKLHTF DSLIALVNGL 240
  241 VKAKNFRFIK VFIQALLQKL EQHCYSGKDG AKQKNLRYVK FNNTLLYYLL KSGNVELFIK 300
  301 TFQEELKFIV SSGLLNHIDG NEHILNFPIH HYLNLLRISN RQEELFNVIS CLQSSPLMKY 360
  361 KLFKEFLMGE LIASFQAFRD PKLVCKYLLS SYSSKASANI LNALGIWGWL YHSKSTTLTA 420
  421 PTLARELKNK NNILPNTMRI GSPVTVPILT ELYRSLLSSS SVSLESGQFK NCLLDLYYKY 480
  481 KSFLSEEAHK YRYWRNDTGI LNVFLNYIRF QAREPRLAYN VLLDFYSQPF AKKVVLTTTL 540
  541 CPFSIVAYKN HTLTQAELSE LLQVMHKNGV PLTFKFCSAM VMHYVKMRDE KEHAPGTIRY 600
  601 SSGALKSGIW L

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ATP22 MAK21 NOC2 RRP5
View Details	Gavin AC, et al. (2002)		AEP1 AEP2 ATP22 HRP1 SES1 TSR1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	VPS64	ATP22	1	Unpublished Fields Lab Data
View Screen	MET18	ATP22	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	ATP22	Huh WK, et al. (2003)

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..611]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.90

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2