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Protein Overview: BTT1

General Information:
Name(s) found: BTT1 / YDR252W [SGD]
Description(s) found:
Found 35 descriptions.
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  • Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 149 amino acids

    Gene Ontology:
    Cellular Component: nascent polypeptide-associated complex [IDALink to PubMed article]
    Biological Process: 'de novo' cotranslational protein folding [IPILink to PubMed article]
    Molecular Function: unfolded protein binding [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVDQEKLAK LHKLSAANKV GGTRRKINKK GNLYNNNDKD NTKLQAELHK LHPMTIENVA  60
   61 EANFFKKNGK VLHFNSAVVQ IAPQCNLTMI HGQPKENTLN GLYPSVASQL GSQELEYLTG 120
  121 LAHNLENEQT VLDQLGDRCS ETKQQVMNS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BTT1 EGD2
    View Details Krogan NJ, et al. (2006) BTT1 CAF130 EGD1 EGD2 PLC1 YJR011C
    View Details Qiu et al. (2008) BTT1 EGD1 EGD2 SSB1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data BTT1 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..149] Pfam 29.366532 No description for PF01849.9 was found. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle