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Protein Overview: PEX5

General Information:
Name(s) found: PEX5 / YDR244W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 612 amino acids

    Gene Ontology:
    Cellular Component: peroxisome [IDALink to PubMed articleLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: protein targeting to peroxisome [IPILink to PubMed article]
    peroxisome organization [TAS]
    Molecular Function: peroxisome matrix targeting signal-1 binding [IPILink to PubMed article]
    peroxisome targeting sequence binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVGSCSVGN NPLAQLHKHT QQNKSLQFNQ KNNGRLNESP LQGTNKPGIS EAFISNVNAI  60
   61 SQENMANMQR FINGEPLIDD KRRMEIGPSS GRLPPFSNVH SLQTSANPTQ IKGVNDISHW 120
  121 SQEFQGSNSI QNRNADTGNS EKAWQRGSTT ASSRFQYPNT MMNNYAYASM NSLSGSRLQS 180
  181 PAFMNQQQSG RSKEGVNEQE QQPWTDQFEK LEKEVSENLD INDEIEKEEN VSEVEQNKPE 240
  241 TVEKEEGVYG DQYQSDFQEV WDSIHKDAEE VLPSELVNDD LNLGEDYLKY LGGRVNGNIE 300
  301 YAFQSNNEYF NNPNAYKIGC LLMENGAKLS EAALAFEAAV KEKPDHVDAW LRLGLVQTQN 360
  361 EKELNGISAL EECLKLDPKN LEAMKTLAIS YINEGYDMSA FTMLDKWAET KYPEIWSRIK 420
  421 QQDDKFQKEK GFTHIDMNAH ITKQFLQLAN NLSTIDPEIQ LCLGLLFYTK DDFDKTIDCF 480
  481 ESALRVNPND ELMWNRLGAS LANSNRSEEA IQAYHRALQL KPSFVRARYN LAVSSMNIGC 540
  541 FKEAAGYLLS VLSMHEVNTN NKKGDVGSLL NTYNDTVIET LKRVFIAMNR DDLLQEVKPG 600
  601 MDLKRFKGEF SF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) PEX10 PEX18 PEX3 PEX5 PEX8

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PEX5 and PEX3 Huh WK, et al. (2003)
    View Data PEX5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..195] deduced N/A No confident structure predictions are available.
    2 View Details [196..395] PSI-BLAST 525.221849 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    3 View Details [396..471] PSI-BLAST 525.221849 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    4 View Details [472..531] PSI-BLAST 525.221849 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    5 View Details [532..612] PSI-BLAST 525.221849 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • peroxisome targeting sequence binding
    		•  6.28836842401449 bayes_pls_golite062009
  • peroxisome matrix targeting signal-1 binding
    		•  5.30441166392789 bayes_pls_golite062009
  • binding
    		•  2.14253214573541 bayes_pls_golite062009
  • protein binding
    		•  1.83529176977066 bayes_pls_golite062009
  • signal sequence binding
    		•  1.13935627118933 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle