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Protein Overview: MSC2

General Information:
Name(s) found: MSC2 / YDR205W [SGD]
Description(s) found:
Found 8 descriptions.
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  • Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 740 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    membrane [ISSLink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: cellular zinc ion homeostasis [IMPLink to PubMed article]
    Molecular Function: cation:cation antiporter activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRGRWCFLV SVSSRIMNLQ ELLAKVPLLL SYPTIILSSN LIVPSHNDLI SRAASTSAAE  60
   61 YADEKLIFFS TDHAIRLIFL PTFVASSFNL FAHYFNFINY SSRRKYYVLF TAIYFLSILT 120
  121 AIFHPIQSTC ITLLIIKLLT TADESSPKIA LNFKTILKTF VPFITLTLVI LRWDPSFDAS 180
  181 SGDVNKISTS LAAYALLILT LRYASPLILS TLSSSIGVVS KDTSVAQHSI SRNKRFPLIL 240
  241 VLPIFSFVLL YLMTIVNKTY NIQLLMVFVF FGCLSIFFLS LKDLFTEDGN QKKGGQEDEY 300
  301 CRMFDIKYMI SYLWLTRFTI LLTGIMAIVV HFLSFNEITS SIKTDLLSLL FVVVAEYVSS 360
  361 FSNKQPDSHS HNHAHHHSHL TDSLPLENES MFKQMALNKD TRSIFSFLLL NTAFMFVQLL 420
  421 YSFRSKSLGL LSDSLHMALD CTSLLLGLIA GVLTKKPASD KFPFGLNYLG TLAGFTNGVL 480
  481 LLGIVCGIFV EAIERIFNPI HLHATNELLV VATLGLLVNL VGLFAFDHGA HDHGGTDNEN 540
  541 MKGIFLHILA DTLGSVGVVI STLLIKLTHW PIFDPIASLL IGSLILLSAL PLLKSTSANI 600
  601 LLRLDDKKHN LVKSALNQIS TTPGITGYTT PRFWPTESGS SGHSHAHTHS HAENHSHEHH 660
  661 HDQKNGSQEH PSLVGYIHVQ YVDGENSTII KKRVEKIFEN VSIKAWVQVE PQNSTCWCRA 720
  721 TSMNTISANP NSLPLQPIAN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..379] deduced N/A No confident structure predictions are available.
    2 View Details [380..740] Pfam 77.79588 Cation efflux family No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle