YRC Public Data Repository - Protein Structure Prediction

Protein:	MSC2
Organism:	Saccharomyces cerevisiae
Length:	740 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSC2.

Description	E-value	Query Range	Subject Range
ZNT5_MOUSE - Zinc transporter 5 OS=Mus musculus GN=Slc30a5 PE=1 SV=1	0.0	[236..717]	[266..730]
SLC30A5 - solute carrier family 30 (zinc transporter), member 5 HGNC:19089\|MIM:6... - carrier family 30 (zinc transporter), member 5 gi\|157169762, gi... - gi\|190689809\|gb\|ACE86679.1\| solute carrier family 30 (zinc transporter), member 5 protein [synthetic...	0.0	[236..712]	[268..729]
CE03664 - WBGene00011821 cobalt uptake like protein status:Predicted TR:Q22541 protein_id:CAA92193.1	2.0E-71	[326..680]	[6..365]
CZCD_BACSU - Cadmium, cobalt and zinc/H(+)-K(+) antiporter OS=Bacillus subtilis (strain 168) GN=czcD PE=1 SV=1 gi\|221314921 - gi\|221314921\|ref\|ZP_03596726.1\| cation-efflux system membrane protein [Bacillus subtilis subsp. subt... gi\|221319843 - gi\|221319843\|ref\|ZP_03601137.1\| cation-efflux system membrane protein [Bacillus subtilis subsp. subt... gi\|221324123 - gi\|221324123\|ref\|ZP_03605417.1\| cation-efflux system membrane protein [Bacillus subtilis subsp. subt... CZCD_BACSU - Cadmium, cobalt and zinc/H(+)-K(+) antiporter OS=Bacillus subtilis GN=czcD PE=1 SV=1	8.0E-69	[391..696]	[1..304]
ZNT4_RAT - Zinc transporter 4 OS=Rattus norvegicus GN=Slc30a4 PE=2 SV=1	1.0E-67	[327..690]	[26..422]
gi\|165924663, gi... - gi\|165924663\|ref\|ZP_02220495.1\| zinc transporter ZitB [Yersinia pestis biovar Orientalis str. F19910... gi\|166011602, gi... - gi\|166011602\|ref\|ZP_02232500.1\| zinc transporter ZitB [Yersinia pestis biovar Antiqua str. E1979001]... gi\|166211318, gi... - gi\|166211318\|ref\|ZP_02237353.1\| zinc transporter ZitB [Yersinia pestis biovar Antiqua str. B42003004... gi\|167050467, gi... - gi\|167399759\|ref\|ZP_02305277.1\| zinc transporter ZitB [Yersinia pestis biovar Antiqua str. UG05-0454... gi\|166962575, gi... - gi\|167419834\|ref\|ZP_02311587.1\| zinc transporter ZitB [Yersinia pestis biovar Orientalis str. MG05-1... gi\|167056778, gi... - gi\|167423929\|ref\|ZP_02315682.1\| zinc transporter ZitB [Yersinia pestis biovar Mediaevalis str. K1973... gi\|145599832, gi... - gi\|145599832\|ref\|YP_001163908.1\| zinc transporter ZitB [Yersinia pestis Pestoides F], gi\|145211528\|g... gi\|22126926, gi\|... - gi\|22126926\|ref\|NP_670349.1\| zinc transporter ZitB [Yersinia pestis KIM], gi\|21959965\|gb\|AAM86600.1\|... gi\|16121429, gi\|... - gi\|218928297\|ref\|YP_002346172.1\| zinc transporter ZitB [Yersinia pestis CO92], gi\|16121429\|ref\|NP_40... gi\|45435719, gi\|... - gi\|45440861\|ref\|NP_992400.1\| zinc transporter ZitB [Yersinia pestis biovar Microtus str. 91001], gi\|... gi\|108778517, gi... - gi\|108806604\|ref\|YP_650520.1\| zinc transporter ZitB [Yersinia pestis Antiqua], gi\|108778517\|gb\|ABG12... gi\|229679239, gi... - gi\|229903469\|ref\|ZP_04518582.1\| zinc efflux system [Yersinia pestis Nepal516], gi\|229679239\|gb\|EEO75... gi\|229894007, gi... - gi\|229894007\|ref\|ZP_04509193.1\| zinc efflux system [Yersinia pestis Pestoides A], gi\|229703892\|gb\|EE... gi\|229689517, gi... - gi\|229843170\|ref\|ZP_04463316.1\| zinc efflux system [Yersinia pestis biovar Orientalis str. India 195... gi\|149366871, gi... - gi\|149366871\|ref\|ZP_01888905.1\| putative cation transport protein [Yersinia pestis CA88-4125], gi\|14... gi\|229841066, gi... - gi\|229841066\|ref\|ZP_04461225.1\| zinc efflux system [Yersinia pestis biovar Orientalis str. PEXU2], g... gi\|165938380, gi... - gi\|89105186\|ref\|ZP_01177710.1\| COG1230: Co/Zn/Cd efflux system component [Yersinia pestis biovar Ori... ZITB_YERPE - Zinc transporter ZitB OS=Yersinia pestis GN=zitB PE=3 SV=1 gi\|167470005 - gi\|167470005\|ref\|ZP_02334709.1\| zinc transporter ZitB [Yersinia pestis FV-1] gi\|162353525, gi... - gi\|77636411\|ref\|ZP_00798485.1\| COG1230: Co/Zn/Cd efflux system component [Yersinia pestis Angola], g... gi\|152959323, gi... - gi\|77632122\|ref\|ZP_00794708.1\| COG1230: Co/Zn/Cd efflux system component [Yersinia pseudotuberculosi...	3.0E-66	[396..689]	[8..296]
gi\|196250048, gi... - gi\|196250048\|ref\|ZP_03148743.1\| cation diffusion facilitator family transporter [Geobacillus sp. G11... gi\|1944409 - gi\|1944409\|dbj\|BAA19587.1\| membrane protein [Geobacillus stearothermophilus]	6.0E-66	[389..687]	[9..301]

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Predicted Domain #1

Region A:
Residues: [1-379]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRGRWCFLV SVSSRIMNLQ ELLAKVPLLL SYPTIILSSN LIVPSHNDLI SRAASTSAAE  60
   61 YADEKLIFFS TDHAIRLIFL PTFVASSFNL FAHYFNFINY SSRRKYYVLF TAIYFLSILT 120
  121 AIFHPIQSTC ITLLIIKLLT TADESSPKIA LNFKTILKTF VPFITLTLVI LRWDPSFDAS 180
  181 SGDVNKISTS LAAYALLILT LRYASPLILS TLSSSIGVVS KDTSVAQHSI SRNKRFPLIL 240
  241 VLPIFSFVLL YLMTIVNKTY NIQLLMVFVF FGCLSIFFLS LKDLFTEDGN QKKGGQEDEY 300
  301 CRMFDIKYMI SYLWLTRFTI LLTGIMAIVV HFLSFNEITS SIKTDLLSLL FVVVAEYVSS 360
  361 FSNKQPDSHS HNHAHHHSH

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [380-740]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTDSLPLENE SMFKQMALNK DTRSIFSFLL LNTAFMFVQL LYSFRSKSLG LLSDSLHMAL  60
   61 DCTSLLLGLI AGVLTKKPAS DKFPFGLNYL GTLAGFTNGV LLLGIVCGIF VEAIERIFNP 120
  121 IHLHATNELL VVATLGLLVN LVGLFAFDHG AHDHGGTDNE NMKGIFLHIL ADTLGSVGVV 180
  181 ISTLLIKLTH WPIFDPIASL LIGSLILLSA LPLLKSTSAN ILLRLDDKKH NLVKSALNQI 240
  241 STTPGITGYT TPRFWPTESG SSGHSHAHTH SHAENHSHEH HHDQKNGSQE HPSLVGYIHV 300
  301 QYVDGENSTI IKKRVEKIFE NVSIKAWVQV EPQNSTCWCR ATSMNTISAN PNSLPLQPIA 360
  361 N

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	77.79588
Match:	PF01545
Description:	Cation efflux family

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits