Protein Overview: CTH1

General Information:
Name(s) found:	CTH1 / YDR151C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|899400\|emb\|CAA90373.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] gi\|6320355\|ref\|NP_010435.1\| Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis; Cth1p [Saccharomyces cerevis [NCBI NR] gi\|52788259\|sp\|P47976.2\|CTH1_YEAST RecName: Full=mRNA decay factor CTH1; AltName: Full=Cysteine-three-histidine protein 1 [NCBI NR] gi\|45269273\|gb\|AAS56016.1\| YDR151C [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S57977 CCCH zinc finger protein CTH1 - yeast (Saccharomyces cerevisiae) [NCBI NR] mRNA decay factor CTH1 OS=Saccharomyces cerevisiae GN=CTH1 PE=1 SV=2 [Swiss-Prot] CTH1 Putative transcription factor, member of the CCCH zinc finger family [mips] Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis [SGD] CTH1, Chr IV from 764171-765148, reverse complement [yeast_orfs2] Chr IV from 764171-765148, reverse complement [yeastorf3.fasta] Chr IV from 765148-764171, reverse complement [yeastorf5.fasta] CTH1 SGDID:S0002558, Chr IV from 765149-764172, reverse complement, Verified ORF [yeastflysequest.fasta] CTH1 SGDID:S0002558, Chr IV from 765150-764173, reverse complement, Verified ORF [10112005cervSGD.fasta] Cth1p [Saccharomyces cerevisiae]gi\|899400\|emb\|CAA90373.1\| unknown [Saccharomyces cerevisiae]gi\|2131388\|pir\|\|S57977 CCCH zinc finger protein CTH1 - yeast (Saccharomyces cerevisiae)gi\|45269273\|gb\|AAS56016.1\| YDR151C [Saccharomyces cerevisiae]gi\|52788259 [nrdb_11152004_Chlamydomonas] (P47976) Zinc finger protein CTH1 [cerv4932.FASTAC] CTH1 SGDID:S000002558, Chr IV from 765150-764173, reverse complement, Verified ORF, "Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] CTH1 SGDID:S000002558, Chr IV from 765152-764175, reverse complement, Verified ORF, "Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with [yeast-contam.fasta] CTH1 SGDID:S000002558, Chr IV from 765153-764176, reverse complement, Verified ORF, "Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis; Cth1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Zinc finger protein CTH1 [nr-271106-contam.fasta] YDR151C [Saccharomyces cerevisiae] [nr-271106-contam.fasta] CTH1 SGDID:S000002558, Chr IV from 765153-764176, reverse complement, Verified ORF, "Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis" [yeast-bovrabprots.fasta] CTH1 SGDID:S000002558, Chr IV from 765152-764175, reverse complement, Verified ORF, "Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis" [yeast-contam_custom.fasta] [chemostatdb.fasta] mRNA decay factor CTH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CTH1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] CTH1 SGDID:S000002558, Chr IV from 765155-764178, Genome Release 64-1-1, reverse complement, Verified ORF, "Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis" [yeast-030211-contam.fasta] CTH1 SGDID:S000002558, Chr IV from 765155-764178, Genome Release 64-2-1, reverse complement, Verified ORF, "Member of the CCCH zinc finger family; similar to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis; CTH1 has a paralog, TIS11, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YDR151C SGDID:S000002558, Chr IV from 765155-764178, Genome Release 64-1-1, reverse complement, Verified ORF, "Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	325 amino acids
Gene Ontology:
Cellular Component:	nucleus [IC]
Biological Process:	cellular iron ion homeostasis [IGI] transcription [ISS]
Molecular Function:	transcription factor activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMPNVAPNSY YLNIPNANST STTTSSIFSD LNKEYESKIK EIEEYYIKTL LNENTDNDDS  60
   61 SSSEGHNINE TDILSEYSPR PSPWLPSKPN CYHPLGDFKD LIISDSRPTN TLPINNPFAG 120
  121 NNNISTLATT EKKRKKRSLE VEINPTYTTS AFSLPLTAEN LQKLSQVDSQ STGLPYTLPI 180
  181 QKTTKLEPCR RAPLQLPQLV NKTLYKTELC ESFTIKGYCK YGNKCQFAHG LNELKFKKKS 240
  241 NNYRTKPCIN WSKLGYCPYG KRCCFKHGDD KDVEIYQNAN DGRSKDTALT PLPTSLAPSN 300
  301 NDNITNLSKP RNLHTSVKAL QRMTW

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CAB1	CTH1	2	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..325]	ORFEUS	9.3	RBP1
2	View Details	[198..325]	PSI-BLAST	25.30103	Structural Basis for Recognition of the mRNA Class II AU-Rich Element by the Tandem Zinc Finger Domain of TIS11d

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2