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Protein Overview: EKI1

General Information:
Name(s) found: EKI1 / YDR147W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 534 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: phosphatidylethanolamine biosynthetic process [IMPLink to PubMed article]
    Molecular Function: ethanolamine kinase activity [IDALink to PubMed article]
    choline kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYTNYSLTSS DAMPRTYLVG TASPEMSKKK RQSANCDKPT RRVIHIIDTN EHSEVDLKNE  60
   61 LPITCTNEDG EMTSSSWTSQ TANDFLKLAY VNAKLDPSLP SQYFKQDIIN VLQSLEIPGW 120
  121 SVPGSKESSL NKNLLTLTQI KGALTNVIYK IHYPNLPPLL MRIFGDSIDS VIDREYELKV 180
  181 IARLSFYDLG PKLEGFFENG RFEKYIEGSR TSTQADFIDR DTSIKIAKKL KELHCTVPLT 240
  241 HKEITDQPSC WTTFDQWIKL IDSHKEWVSN NVNISENLRC SSWNFFLKSF KNYKRWLYND 300
  301 SAFTSKLLRE DDKDSMINSG LKMVFCHNDL QHGNLLFKSK GKDDISVGDL TIIDFEYAGP 360
  361 NPVVFDLSNH LNEWMQDYND VQSFKSHIDK YPKEEDILVF AQSYINHMNE NHVKIASQEV 420
  421 RILYNLIIEW RPCTQLFWCL WALLQSGRLP QRPLIEGEKL MSEKAGLGDE THLMEHKNKE 480
  481 NGKYDCSEDD SFNYLGFCKE KMSVFWGDLI TLGVIDKDCP DIGKTDYLDT KLIF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) EKI1 RTC3 SUC2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data EKI1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..98] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [99..178]
    [192..205]    		 PSI-BLAST 2.522879 Type IIIa 3',5"-aminoglycoside phosphotransferase
    3 View Details [179..191]
    [206..447]    		 PSI-BLAST 2.522879 Type IIIa 3',5"-aminoglycoside phosphotransferase
    4 View Details [448..534] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.56238090010785 bayes_pls_golite062009
  • binding
    		•  2.55015378442547 bayes_pls_golite062009
  • protein kinase activity
    		•  2.44081222683977 bayes_pls_golite062009
  • kinase activity
    		•  2.34459475289562 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.95139794143606 bayes_pls_golite062009
  • transferase activity
    		•  1.80001061545783 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.55379052459468 bayes_pls_golite062009
  • lipid kinase activity
    		•  1.3504796246251 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • choline kinase activity
    		•  1.18757364210199 bayes_pls_golite062009
  • protein binding
    		•  1.12583111976692 bayes_pls_golite062009
  • phosphoinositide 3-kinase activity
    		•  1.10484220525143 bayes_pls_golite062009
  • 1-phosphatidylinositol-3-kinase activity
    		•  1.04034573968654 bayes_pls_golite062009
  • inositol or phosphatidylinositol kinase activity
    		•  0.97254836668426 bayes_pls_golite062009
  • ethanolamine kinase activity
    		•  0.68804237112665 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle