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Protein Overview: KAR4

General Information:
Name(s) found: KAR4 / YCL055W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Transcription factor required for gene regulation in repsonse to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 335 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter by pheromones [IEPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter by pheromones [IDALink to PubMed article][IEPLink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    G1 phase of mitotic cell cycle [IEPLink to PubMed article][IMPLink to PubMed article]
    karyogamy involved in conjugation with cellular fusion [IMPLink to PubMed article]
    meiosis [IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFQDPTYDQ NKSRHINNSH LQGPNQETIE MKSKHVSFKP SRDFHTNDYS NNYIHGKSLP  60
   61 QQHVTNIENR VDGYPKLQKL FQAKAKQINQ FATTPFGCKI GIDSIVPTLN HWIQNENLTF 120
  121 DVVMIGCLTE NQFIYPILTQ LPLDRLISKP GFLFIWANSQ KINELTKLLN NEIWAKKFRR 180
  181 SEELVFVPID KKSPFYPGLD QDDETLMEKM QWHCWMCITG TVRRSTDGHL IHCNVDTDLS 240
  241 IETKDTTNGA VPSHLYRIAE NFSTATRRLH IIPARTGYET PVKVRPGWVI VSPDVMLDNF 300
  301 SPKRYKEEIA NLGSNIPLKN EIELLRPRSP VQKAQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data KAR4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..58] deduced N/A No confident structure predictions are available.
    2 View Details [59..335] MSA 14.026971 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle