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Protein Overview: MXR2

General Information:
Name(s) found: MXR2 / YCL033C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 168 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: response to oxidative stress [IEPLink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: protein-methionine-R-oxide reductase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKWSRLYVI TVRRTFPGRR NIVLTQYWNK SKKMSDESND VKWNDALTPL QLMVLRDKAT  60
   61 ERPNTGAYLH TNESGVYHCA NCDRPLYSSK AKFDARCGWP AFYEEVSPGA ITYHRDNSLM 120
  121 PARVEICCAR CGGHLGHVFE GEGWKQLLNL PKDTRHCVNS ASLNLKKD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..168] PSI-BLAST 184.201249 C-terminal MsrB domain of peptide methionine sulfoxide reductase PilB

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein-methionine-R-oxide reductase activity
    		•  6.23848614648911 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor
    		•  5.90194589149201 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  3.4377744251418 bayes_pls_golite062009
  • peptide-methionine-(S)-S-oxide reductase activity
    		•  1.80676476343543 bayes_pls_golite062009
  • binding
    		•  1.67290562818139 bayes_pls_golite062009
  • catalytic activity
    		•  0.566791077255496 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.555078494441175 bayes_pls_golite062009
  • ion binding
    		•  0.415760364192452 bayes_pls_golite062009
  • cation binding
    		•  0.404651661251597 bayes_pls_golite062009
  • metal ion binding
    		•  0.404651661251597 bayes_pls_golite062009
  • DNA binding
    		•  0.215568693193579 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.183261590647643 bayes_pls_golite062009
  • protein binding
    		•  0.0755837372617499 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle