YRC Public Data Repository - Protein Structure Prediction

Protein:	MXR2
Organism:	Saccharomyces cerevisiae
Length:	168 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MXR2.

Description	E-value	Query Range	Subject Range
gi\|151943796 - gi\|151943796\|gb\|EDN62096.1\| conserved protein [Saccharomyces cerevisiae YJM789] MXR2 - Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur... gi\|190406413 - gi\|190406413\|gb\|EDV09680.1\| peptide methionine sulfoxide reductase msrB [Saccharomyces cerevisiae RM... MXR2_YEAST - Peptide methionine sulfoxide reductase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...	1.0E-69	[1..168]	[1..168]
gi\|7429280 - pir\|\|S74642 hypothetical protein sll1680 - Synechocystis sp. (strain PCC 6803) gi\|16329386, gi\|... - gi\|1651867\|dbj\|BAA16794.1\| sll1680 [Synechocystis sp. PCC 6803], gi\|16329386\|ref\|NP_440114.1\| methio...	6.0E-59	[4..166]	[18..174]
MSRB2_ARATH - Peptide methionine sulfoxide reductase B2, chloroplastic OS=Arabidopsis thaliana GN=MSRB2 PE=1 SV=1	1.0E-56	[11..165]	[52..195]
MSRB_RALSO - Peptide methionine sulfoxide reductase msrB OS=Ralstonia solanacearum GN=msrB PE=3 SV=1 MSRB_RALSO - Peptide methionine sulfoxide reductase MsrB OS=Ralstonia solanacearum (strain GMI1000) GN=msrB PE=3 ...	2.0E-55	[34..165]	[1..126]
gi\|15964744 - gi\|15964744\|ref\|NP_385097.1\| hypothetical protein SMc00117 [Sinorhizobium meliloti 1021] gi\|15073922 - gi\|15073922\|emb\|CAC45563.1\| CONSERVED HYPOTHETICAL PROTEIN [Sinorhizobium meliloti]	1.0E-54	[28..168]	[19..153]
gi\|205272769, gi... - gi\|205352988\|ref\|YP_002226789.1\| methionine sulfoxide reductase B [Salmonella enterica subsp. enteri... gi\|16502900, gi\|... - gi\|25302984\|pir\|\|AF0711 conserved hypothetical protein STY1824 [imported] - Salmonella enterica subs... gi\|16764642, gi\|... - gi\|16764642\|ref\|NP_460257.1\| methionine sulfoxide reductase B [Salmonella typhimurium LT2], gi\|16419... lcl\|NC_016856.1_... - [gene=yeaA] [protein=methionine sulfoxide reductase B] [protein_id=YP_005237142.1] [location=1379977... gi\|29137264, gi\|... - gi\|29141636\|ref\|NP_804978.1\| methionine sulfoxide reductase B [Salmonella enterica subsp. enterica s... gi\|16760604 - gi\|16760604\|ref\|NP_456221.1\| methionine sulfoxide reductase B [Salmonella enterica subsp. enterica s... gi\|207857208, gi... - gi\|207857208\|ref\|YP_002243859.1\| methionine sulfoxide reductase B [Salmonella enterica subsp. enteri... gi\|224468729, gi... - gi\|224584202\|ref\|YP_002638000.1\| methionine sulfoxide reductase B [Salmonella enterica subsp. enteri... gi\|62179874, gi\|... - gi\|62179874\|ref\|YP_216291.1\| methionine sulfoxide reductase B [Salmonella enterica subsp. enterica s...	2.0E-54	[24..168]	[1..139]
MSRB_AGRFC - Peptide methionine sulfoxide reductase MsrB OS=Agrobacterium fabrum (strain C58 / ATCC 33970) GN=msr... gi\|25302988, gi\|... - gi\|25302988\|pir\|\|AD2688 transcription regulator Atu0908 [imported] - Agrobacterium tumefaciens (stra...	5.0E-54	[34..166]	[7..133]
gi\|16122390, gi\|... - gi\|218929258\|ref\|YP_002347133.1\| methionine sulfoxide reductase B [Yersinia pestis CO92], gi\|1612239... MSRB_YERPS - Peptide methionine sulfoxide reductase MsrB OS=Yersinia pseudotuberculosis serotype I (strain IP3295... gi\|165991976, gi... - gi\|166009421\|ref\|ZP_02230319.1\| methionine-R-sulfoxide reductase [Yersinia pestis biovar Antiqua str... gi\|165927688, gi... - gi\|165927688\|ref\|ZP_02223520.1\| methionine-R-sulfoxide reductase [Yersinia pestis biovar Orientalis ... gi\|167401382, gi... - gi\|167401382\|ref\|ZP_02306879.1\| methionine-R-sulfoxide reductase [Yersinia pestis biovar Antiqua str... gi\|166207961, gi... - gi\|166210781\|ref\|ZP_02236816.1\| methionine-R-sulfoxide reductase [Yersinia pestis biovar Antiqua str... gi\|167054465, gi... - gi\|167426589\|ref\|ZP_02318342.1\| methionine-R-sulfoxide reductase [Yersinia pestis biovar Mediaevalis... gi\|149292332, gi... - gi\|149365919\|ref\|ZP_01887954.1\| peptide methionine sulfoxide reductase [Yersinia pestis CA88-4125], ... gi\|167420425, gi... - gi\|167420425\|ref\|ZP_02312178.1\| methionine-R-sulfoxide reductase [Yersinia pestis biovar Orientalis ... MSRB_YERPE - Peptide methionine sulfoxide reductase MsrB OS=Yersinia pestis GN=msrB PE=3 SV=1 gi\|229894832, gi... - gi\|229894832\|ref\|ZP_04510012.1\| methionine sulfoxide reductase B [Yersinia pestis Pestoides A], gi\|2... MSRB_YERPA - Peptide methionine sulfoxide reductase MsrB OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=msrB ... MSRB_YERPP - Peptide methionine sulfoxide reductase MsrB OS=Yersinia pestis (strain Pestoides F) GN=msrB PE=3 SV=... MSRB_YERPY - Peptide methionine sulfoxide reductase MsrB OS=Yersinia pseudotuberculosis serotype O:3 (strain YPII... gi\|229897576, gi... - gi\|229897576\|ref\|ZP_04512732.1\| methionine sulfoxide reductase B [Yersinia pestis biovar Orientalis ... MSRB_YERPN - Peptide methionine sulfoxide reductase MsrB OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=msrB... gi\|167470633 - gi\|167470633\|ref\|ZP_02335337.1\| methionine sulfoxide reductase B [Yersinia pestis FV-1] gi\|229688787, gi... - gi\|229898221\|ref\|ZP_04513369.1\| methionine sulfoxide reductase B [Yersinia pestis biovar Orientalis ... MSRB_YERPG - Peptide methionine sulfoxide reductase MsrB OS=Yersinia pestis bv. Antiqua (strain Angola) GN=msrB P... MSRB_YERPB - Peptide methionine sulfoxide reductase MsrB OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+... MSRB_YERP3 - Peptide methionine sulfoxide reductase MsrB OS=Yersinia pseudotuberculosis serotype O:1b (strain IP ... MSRB_YERPS - Peptide methionine sulfoxide reductase MsrB OS=Yersinia pseudotuberculosis GN=msrB PE=3 SV=1 gi\|89101824, gi\|... - gi\|89101824\|ref\|ZP_01174516.1\| COG0229: Conserved domain frequently associated with peptide methioni...	3.0E-53	[34..168]	[1..129]
MSRAB_HAEIN - Peptide methionine sulfoxide reductase MsrA/MsrB OS=Haemophilus influenzae (strain ATCC 51907 / DSM ... MSRAB_HAEIN, MSA... - Peptide methionine sulfoxide reductase msrA/msrB OS=Haemophilus influenzae GN=msrAB PE=1 SV=1, (P452...	7.0E-53	[32..165]	[205..333]
gi\|15842212, gi\|... - gi\|15842212\|ref\|NP_337249.1\| hypothetical protein MT2748 [Mycobacterium tuberculosis CDC1551], gi\|13... gi\|1550715, gi\|1... - gi\|15609811\|ref\|NP_217190.1\| hypothetical protein Rv2674 [Mycobacterium tuberculosis H37Rv], gi\|1550... gi\|121494197, gi... - gi\|121638549\|ref\|YP_978773.1\| hypothetical protein BCG_2687 [Mycobacterium bovis BCG str. Pasteur 11... gi\|197738327, gi... - gi\|254365336\|ref\|ZP_04981381.1\| conserved hypothetical protein [Mycobacterium tuberculosis str. Haar... gi\|148662515, gi... - gi\|148662515\|ref\|YP_001284038.1\| hypothetical protein MRA_2702 [Mycobacterium tuberculosis H37Ra], g... gi\|148722391, gi... - gi\|76783677\|ref\|ZP_00770868.1\| COG0229: Conserved domain frequently associated with peptide methioni... gi\|224991041, gi... - gi\|224991041\|ref\|YP_002645730.1\| hypothetical protein JTY_2681 [Mycobacterium bovis BCG str. Tokyo 1... gi\|253319747, gi... - gi\|253798244\|ref\|YP_003031245.1\| methionine-R-sulfoxide reductase [Mycobacterium tuberculosis KZN 14... gi\|254551729 - gi\|254551729\|ref\|ZP_05142176.1\| methionine-R-sulfoxide reductase [Mycobacterium tuberculosis '98-R60... gi\|254816508 - gi\|254816508\|ref\|ZP_05221509.1\| hypothetical protein MtubKZN_12353 [Mycobacterium tuberculosis KZN 4... gi\|255097493 - gi\|255097493\|ref\|ZP_05326971.1\| hypothetical protein MtubK_15068 [Mycobacterium tuberculosis KZN 605... gi\|31619440, gi\|... - gi\|31793846\|ref\|NP_856339.1\| hypothetical protein Mb2693 [Mycobacterium bovis AF2122/97], gi\|3161944... gi\|215404637 - gi\|215404637\|ref\|ZP_03416818.1\| hypothetical protein Mtub0_13315 [Mycobacterium tuberculosis 02_1987... gi\|7444913 - pir\|\|F70968 hypothetical protein Rv2674 - Mycobacterium tuberculosis (strain H37RV) gi\|215428100 - gi\|215428100\|ref\|ZP_03426019.1\| hypothetical protein MtubT9_17588 [Mycobacterium tuberculosis T92] gi\|215412472 - gi\|215412472\|ref\|ZP_03421212.1\| hypothetical protein Mtub9_14030 [Mycobacterium tuberculosis 94_M424... gi\|218754411 - gi\|218754411\|ref\|ZP_03533207.1\| hypothetical protein MtubG1_13704 [Mycobacterium tuberculosis GM 150... gi\|215446930 - gi\|215446930\|ref\|ZP_03433682.1\| hypothetical protein MtubT_13692 [Mycobacterium tuberculosis T85]	2.0E-52	[33..166]	[3..132]

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Predicted Domain #1

Region A:
Residues: [1-168]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKWSRLYVI TVRRTFPGRR NIVLTQYWNK SKKMSDESND VKWNDALTPL QLMVLRDKAT  60
   61 ERPNTGAYLH TNESGVYHCA NCDRPLYSSK AKFDARCGWP AFYEEVSPGA ITYHRDNSLM 120
  121 PARVEICCAR CGGHLGHVFE GEGWKQLLNL PKDTRHCVNS ASLNLKKD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	184.201249
Match:	1l1dA_
Description:	C-terminal MsrB domain of peptide methionine sulfoxide reductase PilB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein-methionine-R-oxide reductase activity	6.23848614648911	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor	5.90194589149201	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	3.4377744251418	bayes_pls_golite062009
peptide-methionine-(S)-S-oxide reductase activity	1.80676476343543	bayes_pls_golite062009
binding	1.67290562818139	bayes_pls_golite062009
catalytic activity	0.566791077255496	bayes_pls_golite062009
nucleic acid binding	0.555078494441175	bayes_pls_golite062009
ion binding	0.415760364192452	bayes_pls_golite062009
cation binding	0.404651661251597	bayes_pls_golite062009
metal ion binding	0.404651661251597	bayes_pls_golite062009
DNA binding	0.215568693193579	bayes_pls_golite062009
transcription regulator activity	0.183261590647643	bayes_pls_golite062009
protein binding	0.0755837372617499	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: