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Protein Overview: THI2

General Information:
Name(s) found: THI2 / YBR240C [SGD]
Description(s) found:
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  • gi|6319717|ref|NP_009799.1| Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes; Thi2p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S46117 probable regulatory protein YBR240c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|586367|sp|P38141.1|THI2_YEAST RecName: Full=Thiamine biosynthesis regulatory protein [NCBI NR]
  • gi|536647|emb|CAA85203.1| THI2 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|2373393|dbj|BAA22093.1| THI2 positive regulatory protein of thiamin synthesis [Saccharomyces cerevisiae] [NCBI NR]
  • Thiamine biosynthesis regulatory protein OS=Saccharomyces cerevisiae GN=THI2 PE=2 SV=1 [Swiss-Prot]
  • THI2 Regulator of the thiamine biosynthetic genes [mips]
  • Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes [SGD]
  • THI2, Chr II from 700448-701800, reverse complement [yeast_orfs2]
  • Chr II from 700448-701800, reverse complement [yeastorf3.fasta]
  • Chr II from 700447-701799, reverse complement [yeastorf4.fasta]
  • Chr II from 701797-700445, reverse complement [yeastorf5.fasta]
  • (P38141) Thiamine biosynthesis regulatory protein [4932.FASTACCERV.txt]
  • THI2 SGDID:S0000444, Chr II from 701799-700447, reverse complement, Verified ORF [yeastflysequest.fasta]
  • THI2 SGDID:S0000444, Chr II from 701837-700485, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Thi2p [Saccharomyces cerevisiae]gi|536647|emb|CAA85203.1| THI2 [Saccharomyces cerevisiae]gi|626837|pir||S46117 probable regulatory protein YBR240c - yeast (Saccharomyces cerevisiae)gi|2373393|dbj|BAA22093.1| THI2 positive regulatory protein of thiamin [nrdb_11152004_Chlamydomonas]
  • THI2 SGDID:S000000444, Chr II from 701837-700485, reverse complement, Verified ORF, "Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • THI2 positive regulatory protein of thiamin synthesis [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • THI2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Thiamine biosynthesis regulatory protein [nr-271106-contam.fasta]
  • Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes; Thi2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Thiamine biosynthesis regulatory protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=THI2 PE=2 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • THI2 SGDID:S000000444, Chr II from 701842-700490, Genome Release 64-1-1, reverse complement, Verified ORF, "Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes" [yeast-030211-contam.fasta]
  • Thiamine biosynthesis regulatory protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=THI2 PE=4 SV=1 [YEAST.fasta.20131015]
  • THI2 SGDID:S000000444, Chr II from 701842-700490, Genome Release 64-2-1, reverse complement, Verified ORF, "Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type" [20141208_orf_trans.fasta]
  • YBR240C SGDID:S000000444, Chr II from 701842-700490, Genome Release 64-1-1, reverse complement, Verified ORF, "Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • Thiamine biosynthesis regulatory protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=THI2 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Saccharomyces cerevisiae
    Length: 450 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article][IDALink to PubMed article]
    Biological Process: positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article][ISSLink to PubMed article]
    thiamin biosynthetic process [IMPLink to PubMed article][IPILink to PubMed article][TASLink to PubMed article]
    Molecular Function: transcription activator activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVNSKRQQRS KKVASSSKVP PTKGRTFTGC WACRFKKRRC DENRPICSLC AKHGDNCSYD  60
   61 IRLMWLEENI YKVRKHSLIS SLQARKSKSK PLCQKISKSR FKQMTHFRQL SPPTSDCEDS 120
  121 VHEASKETTL PNDNTFTISV RRLKIYNNAV ASVFGSMTNR DYTQKRIDKK LDELLNMVEN 180
  181 DISVVNLNCS KHGPYSVFRA NPAAVTSALT DQLPSPGHSM SSAEETTTAA LSSPPEDSTS 240
  241 LIDIIQGKIF GILWFNCYGN MILNRQEYTT WFINKMRNSL TTEFIRFLGK IIDDPDINMA 300
  301 SCLFKECIAR WSCVDWQSIA ITMLVIIHGY TCPNLTKLLR VWFLQQKLLR FSMYPLVNFI 360
  361 INNTQDLDVL YHCNGLLGNA DLFEDPYQDE LTSELHVLVT ERLVNSWKDT ILQQLCSCQD 420
  421 TTLSCSQLRY WQLQLKCNQQ FYKDVYAMQD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..115] PSI-BLAST 11.39794 PPR1
    2 View Details [116..450] deduced N/A No confident structure predictions are available.
    3 View Details [259..450] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.56444258780502 bayes_pls_golite062009
  • DNA binding
    		•  4.26146437716972 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.17369933547911 bayes_pls_golite062009
  • transcription factor activity
    		•  3.049435548132 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.98081393153291 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.93914501897006 bayes_pls_golite062009
  • binding
    		•  2.91929847152301 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  2.44382866473054 bayes_pls_golite062009
  • transcription activator activity
    		•  2.24483536326713 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle