Protein Overview: EXO5

General Information:
Name(s) found:	EXO5 / YBR163W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6319640\|ref\|NP_009722.1\| Protein of unknown function, shows similarity to RNA-processing protein Pta1p; Dem1p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S46034 hypothetical protein YBR163w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|586302\|sp\|P38289.1\|DEM1_YEAST RecName: Full=Defects in morphology protein 1, mitochondrial; Flags: Precursor [NCBI NR] gi\|536500\|emb\|CAA85123.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] Uncharacterized protein YBR163W - Saccharomyces cerevisiae (Baker's yeast) [Swiss-Prot] Defects in morphology protein 1, mitochondrial OS=Saccharomyces cerevisiae GN=DEM1 PE=1 SV=1 [Swiss-Prot] DEM1 Protein of unknown function localised to mitochondria [mips] Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2 [SGD] DEM1, Chr II from 565681-567438 [yeast_orfs2] Chr II from 565681-567438 [yeastorf3.fasta] Chr II from 565680-567437 [yeastorf4.fasta] Chr II from 565678-567435 [yeastorf5.fasta] (P38289) Hypothetical 67.6 kDa protein in CDC28-ARL1 intergenic region [4932.FASTACCERV.txt] DEM1 SGDID:S0000367, Chr II from 565680-567437, Verified ORF [yeastflysequest.fasta] DEM1 SGDID:S0000367, Chr II from 565718-567475, Verified ORF [10112005cervSGD.fasta] Dem1p [Saccharomyces cerevisiae]gi\|536500\|emb\|CAA85123.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|626531\|pir\|\|S46034 hypothetical protein YBR163w - yeast (Saccharomyces cerevisiae)gi\|586302\|sp\|P38289\|YB13_YEAST HYPOTHETICAL 67.6 KD PROTEIN [nrdb_11152004_Chlamydomonas] DEM1 SGDID:S000000367, Chr II from 565718-567475, Verified ORF, "Protein of unknown function, shows similarity to RNA-processing protein Pta1p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] DEM1 SGDID:S000000367, Chr II from 565718-567475, Verified ORF, "Mitochondrial protein of unknown function; null mutant has defects in cell morphology and in response to air drying; may be regulated by the transcription factor Ace2" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein of unknown function, shows similarity to RNA-processing protein Pta1p; Dem1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Uncharacterized protein YBR163W [nr-271106-contam.fasta] [chemostatdb.fasta] EXO5 SGDID:S000000367, Chr II from 565723-567480, Genome Release 64-1-1, Verified ORF, "Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2" [yeast-030211-contam.fasta] EXO5 SGDID:S000000367, Chr II from 565723-567480, Genome Release 64-2-1, Verified ORF, "Mitochondrial 5'-3' exonuclease and sliding exonuclease; required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2" [20141208_orf_trans.fasta] TR1747\|c0_g1_i1\|g.1270 ORF TR1747\|c0_g1_i1\|g.1270 TR1747\|c0_g1_i1\|m.1270 type:complete len:586 (+) TR1747\|c0_g1_i1:108-1865(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] YBR163W SGDID:S000000367, Chr II from 565723-567480, Genome Release 64-1-1, Verified ORF, "Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] ID=asmbl_4749\|g.3024 ORF ID=asmbl_4749\|g.3024 ID=asmbl_4749\|m.3024 type:complete len:586 (+) ID=asmbl_4749:118-1875(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	585 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA]
Biological Process:	biological_process [ND]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLGRALINKY GFLIHPRRFV HLNDKSLDGT FILPSKKNHM YDVPTNDPSG ILNASDIDRI  60
   61 NNLPFFDNTS PTKETNTKEG ALLSEKLASV KELFGEDPEN PSFINYRFPR GLENPYFDIQ 120
  121 VNQLKKKRLS VTQLCTTQNW CELRNFYDFY SQNLSNQLLN LKFQVQKGKK IHKSLEDETH 180
  181 PELNQYKSFT HNFLALTKLS MDIDNDMDAL LDNWFNSINR LVSLFTKGDG HAREIVCHGF 240
  241 INLEDGKLVE HLLNSDSKTK ENVIISGVID HLTLRNRHNH QVQKGAAHLD TEYQSWGNIL 300
  301 TNLLSNLKEL KSNNEIVISD IKTRSVPKIP SIESVIESSK LQTMYYKFFF SHLSQDMTQT 360
  361 YHSFLINAQR RGLDVDAPIN PTKILTFILT NPLFANDVKN LLYGLPINHS AFDNDAKGSN 420
  421 TFDMTAFNDL LDRGPTSFNV PIEQDEDSSE STKCVSLRDY GHFYTKWKTP LTLKYFAARL 480
  481 SQIYFIVGNL VSNDLMIEYY YHNDNFHNII FPYDPLKLGT HAHDSAMVWF GGRDMHPIEP 540
  541 TQKNFNTYCK FCDYRHVCSW KNKNELKLID LGKELKKIIL ESSMK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MIH1	control 1	McCusker D, et al (2007)
View Run	MLP2	#29 Asynchronous Prep5-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SEC17	EXO5	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	EXO5	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..585]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2