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Protein Overview: UBP14

General Information:
Name(s) found: UBP14 / YBR058C [SGD]
Description(s) found:
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  • pir||S45916 hypothetical protein YBR058c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|586499|sp|P38237|UBP14_YEAST Ubiquitin carboxyl-terminal hydrolase 14 (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) (Deubiquitinating enzyme 14) (Glucose-induced degradation protein 6) [NCBI NR]
  • gi|559955|emb|CAA86402.1| putative protein [Saccharomyces cerevisiae] [NCBI NR]
  • gi|536297|emb|CAA85001.1| UBP14 [Saccharomyces cerevisiae] [NCBI NR]
  • (P38237) Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.1.2.15) (Ubiquitin thiolesterase 14) (Ubiquitin-specific processing protease 14) (Deubiquitinating enzyme 14) [Swiss-Prot]
  • (P38237) Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.1.2.15) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) (Deubiquitinating enzyme 14) (Glucose-induced degradation protein 6) [Swiss-Prot]
  • UBP14 - ubiquitin specific protease [mips]
  • Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T [SGD]
  • UBP14, Chr II from 353631-356042, reverse complement [yeast_orfs2]
  • Chr II from 353631-356042, reverse complement [yeastorf3.fasta]
  • putative protein [Saccharomyces cerevisiae]gi|536297|emb|CAA85001.1| UBP14 [Saccharomyces cerevisiae]gi|626503|pir||S45916 hypothetical protein YBR058c - yeast (Saccharomyces cerevisiae)gi|586499|sp|P38237|UBPE_YEAST Ubiquitin carboxyl-terminal hydrola [nrdb_11152004_Chlamydomonas]
  • UBP14 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Ubiquitin carboxyl-terminal hydrolase 14 (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) (Deubiquitinating enzyme 14) (Glucose-induced degradation protein 6) [nr-271106-contam.fasta]
  • putative protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 803 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ICLink to PubMed article]
    Biological Process: protein deubiquitination [TASLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    negative regulation of gluconeogenesis [IMPLink to PubMed article]
    Molecular Function: ubiquitin-specific protease activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVEMTGKFI QKESPKSFSH SEMAEAVLEN VNVPAVVSKD ECIYCFESPY NEPLALNASP  60
   61 KHSLNICLNC FQATCNRHVP LHIRVTEYAC DTIHSNYLTI AKVEKPKQEN VEENNNNKKI 120
  121 KLQVIETSED DTHNTIWSLQ RFNGENVPRT VLSKSTDSDI SSTALEKIEK ILKAKSQDFE 180
  181 DKKNSWVLEI STCPHTENFQ IPSKPENTVN LNQCSSCDLT QNLWLCLHCG NIGCGREQIG 240
  241 IDGHSHALDH YRSNNNHPLA IKLGSLSSST YDLYCYACDD ETRFPDNVNL GSALQIYGIN 300
  301 IQEKIADEKT LVQLQVEQNE NWQFRMVDSS GKEFEKLSAS KNYGCGLINL GNSCYLNSVI 360
  361 QSLVNGGVPN WSLDFLGSKF PLDVVYPDNN LKCQWIKLLN AMKCEPELYP NGIKPTTFKK 420
  421 CIGQNHQEFS SNRQQDAMEF LTFLLDLLDK KFFSSSSSGI PNPNDLVRFM MEDRLQCNIC 480
  481 GKVKYSYEPT EAIQIPLEEN DEPQDMLERI KAYFEGQTIE FKCANCKEKV TANKKPGFKS 540
  541 LPQTLILNPI RIRLQNWIPV KTSNELSLPG LIDRDDMLDV SSYLSQGFDP QTENLLPDED 600
  601 ENRSSFTPNQ CSISQLIEMG FTQNASVRAL FNTGNQDAES AMNWLFQHMD DPDLNDPFVP 660
  661 PPNVPKKDKR EVDEVSLTSM LSMGLNPNLC RKALILNNGD VNRSVEWVFN NMDDDGTFPE 720
  721 PEVPNEEQQQ KKDLGYSTAK PYALTAVICH KGNSVHSGHY VVFIRKLVAD KWKWVLYNDE 780
  781 KLVAADSIED MKKNGYIYFY TRC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..212] deduced N/A No confident structure predictions are available.
    2 View Details [213..318] Pfam 30.346787 Zn-finger in ubiquitin-hydrolases and other protein No confident structure predictions are available.
    3 View Details [319..377] Pfam 9.0 No description for PF00442 was found. No confident structure predictions are available.
    4 View Details [378..501] deduced N/A Confident ab initio structure predictions are available.
    5 View Details [502..601] MSA 5.216993 View MSA. No confident structure predictions are available.
    6 View Details [602..661] Pfam 6.408935 UBA/TS-N domain No confident structure predictions are available.
    7 View Details [662..726] Pfam 5.638272 UBA/TS-N domain No confident structure predictions are available.
    8 View Details [727..803] Pfam 22.124939 Ubiquitin carboxyl-terminal hydrolase No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle