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Protein Overview: SCO2

General Information:
Name(s) found: SCO2 / YBR024W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 301 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial envelope [IDALink to PubMed article]
    Biological Process: copper ion transport [ISSLink to PubMed article]
    Molecular Function: thioredoxin peroxidase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNSSRKYAC RSLFRQANVS IKGLFYNGGA YRRGFSTGCC LRSDNKESPS ARQPLDRLQL  60
   61 GDEINEPEPI RTRFFQFSRW KATIALLLLS GGTYAYLSRK RRLLETEKEA DANRAYGSVA 120
  121 LGGPFNLTDF NGKPFTEENL KGKFSILYFG FSHCPDICPE ELDRLTYWIS ELDDKDHIKI 180
  181 QPLFISCDPA RDTPDVLKEY LSDFHPAIIG LTGTYDQVKS VCKKYKVYFS TPRDVKPNQD 240
  241 YLVDHSIFFY LIDPEGQFID ALGRNYDEQS GLEKIREQIQ AYVPKEERER RSKKWYSFIF 300
  301 N

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) COX17 SCO1 SCO2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..109] deduced N/A No confident structure predictions are available.
    2 View Details [110..301] PSI-BLAST 54.0 Thioredoxin peroxidase 2 (thioredoxin peroxidase B, 2-cys peroxiredoxin)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • antioxidant activity
    		•  3.8464796631544 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  3.44705858438242 bayes_pls_golite062009
  • peroxidase activity
    		•  3.44705858438242 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.31714727285588 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  2.23310780102446 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  2.12777217096121 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  2.012364779649 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  1.96134566495756 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  1.58488640079086 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  1.42158072441985 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.32811008894503 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  1.29215364159258 bayes_pls_golite062009
  • glutathione transferase activity
    		•  1.17103672502279 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.98873267176254 bayes_pls_golite062009
  • copper ion binding
    		•  0.727599469956102 bayes_pls_golite062009
  • binding
    		•  0.680816432660797 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  0.669808779454721 bayes_pls_golite062009
  • copper chaperone activity
    		•  0.442181439383149 bayes_pls_golite062009
  • protein binding
    		•  0.341730456502484 bayes_pls_golite062009
  • hydrolase activity
    		•  0.245867695453855 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  0.0719543694089202 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle