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View Structure Prediction Details

Protein: SCO2
Organism: Saccharomyces cerevisiae
Length: 301 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SCO2.

Description E-value Query
Range		 Subject
Range
gi|207347782 - gi|207347782|gb|EDZ73851.1| YBR024Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|151946417 - gi|151946417|gb|EDN64639.1| suppressor of cytochrome oxidase deficiency [Saccharomyces cerevisiae YJ...
SCO2 - Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant func...
SCO2_YEAST - Protein SCO2, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SCO2 PE=1 SV...
 3.0E-75 [1..301] [1..301]
SCO12_ARATH - Protein SCO1 homolog 2, mitochondrial OS=Arabidopsis thaliana GN=HCC2 PE=2 SV=1
 4.0E-57 [10..281] [4..273]
gi|2352262 - gi|2352262|gb|AAB68798.1| peroxidoxin-1 [Dirofilaria immitis]
 2.0E-54 [109..296] [1..179]
PRDX_ASCSU - Peroxiredoxin OS=Ascaris suum PE=2 SV=1
 2.0E-54 [113..295] [1..174]
PRDX3_BOVIN - Thioredoxin-dependent peroxide reductase, mitochondrial OS=Bos taurus GN=PRDX3 PE=1 SV=2
 3.0E-54 [55..295] [17..234]
gi|3193232 - gi|3193232|gb|AAC77922.1| peroxidoxin-2 [Onchocerca ochengi]
 4.0E-54 [109..296] [1..179]
gi|14250063 - gi|14250063|gb|AAH08435.1| Peroxiredoxin 3 [Homo sapiens]
 6.0E-54 [63..295] [10..233]
gi|3603241 - gi|3603241|gb|AAC35744.1| type II peroxiredoxin 1 [Mus musculus]
 7.0E-54 [116..295] [6..176]
gi|632720 - gi|632720|gb|AAB32034.1| TSA=thiol-specific antioxidant [rats, brain, Peptide, 198 aa]
PRDX2_RAT - Peroxiredoxin-2 OS=Rattus norvegicus GN=Prdx2 PE=1 SV=3
 8.0E-54 [118..295] [8..176]

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Predicted Domain #1
Region A:
Residues: [1-109] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNSSRKYAC RSLFRQANVS IKGLFYNGGA YRRGFSTGCC LRSDNKESPS ARQPLDRLQL  60
   61 GDEINEPEPI RTRFFQFSRW KATIALLLLS GGTYAYLSRK RRLLETEKE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [110-301] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADANRAYGSV ALGGPFNLTD FNGKPFTEEN LKGKFSILYF GFSHCPDICP EELDRLTYWI  60
   61 SELDDKDHIK IQPLFISCDP ARDTPDVLKE YLSDFHPAII GLTGTYDQVK SVCKKYKVYF 120
  121 STPRDVKPNQ DYLVDHSIFF YLIDPEGQFI DALGRNYDEQ SGLEKIREQI QAYVPKEERE 180
  181 RRSKKWYSFI FN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.0
Match: 1qq2A_
Description: Thioredoxin peroxidase 2 (thioredoxin peroxidase B, 2-cys peroxiredoxin)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
antioxidant activity 3.8464796631544 bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor 3.44705858438242 bayes_pls_golite062009
peroxidase activity 3.44705858438242 bayes_pls_golite062009
oxidoreductase activity 2.31714727285588 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 2.23310780102446 bayes_pls_golite062009
peroxiredoxin activity 2.12777217096121 bayes_pls_golite062009
glutathione peroxidase activity 2.012364779649 bayes_pls_golite062009
thioredoxin peroxidase activity 1.96134566495756 bayes_pls_golite062009
NADH dehydrogenase activity 1.58488640079086 bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity 1.42158072441985 bayes_pls_golite062009
disulfide oxidoreductase activity 1.32811008894503 bayes_pls_golite062009
NADH dehydrogenase (quinone) activity 1.29215364159258 bayes_pls_golite062009
glutathione transferase activity 1.17103672502279 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 0.98873267176254 bayes_pls_golite062009
copper ion binding 0.727599469956102 bayes_pls_golite062009
binding 0.680816432660797 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 0.669808779454721 bayes_pls_golite062009
copper chaperone activity 0.442181439383149 bayes_pls_golite062009
protein binding 0.341730456502484 bayes_pls_golite062009
hydrolase activity 0.245867695453855 bayes_pls_golite062009
protein disulfide oxidoreductase activity 0.0719543694089202 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle