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Protein Overview: FUR4

General Information:
Name(s) found: FUR4 / YBR021W [SGD]
Description(s) found:
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  • gi|6319495|ref|NP_009577.1| Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues; Fur4p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S45877 uracil transport protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|585161|sp|P05316.2|FUR4_YEAST RecName: Full=Uracil permease [NCBI NR]
  • gi|536226|emb|CAA84963.1| FUR4 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|498750|emb|CAA53678.1| uracil permease [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1587579|prf||2206497B uracil permease [NCBI NR]
  • Uracil permease OS=Saccharomyces cerevisiae GN=FUR4 PE=1 SV=2 [Swiss-Prot]
  • FUR4 Uracil permease [mips]
  • Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues [SGD]
  • FUR4, Chr II from 281402-283303 [yeast_orfs2]
  • Chr II from 281402-283303 [yeastorf3.fasta]
  • (P05316) Uracil permease [4932.FASTACCERV.txt]
  • FUR4 SGDID:S0000225, Chr II from 281405-283306, Verified ORF [yeastflysequest.fasta]
  • FUR4 SGDID:S0000225, Chr II from 281443-283344, Verified ORF [10112005cervSGD.fasta]
  • Fur4p [Saccharomyces cerevisiae]gi|536226|emb|CAA84963.1| FUR4 [Saccharomyces cerevisiae]gi|498750|emb|CAA53678.1| uracil permease [Saccharomyces cerevisiae]gi|585161|sp|P05316|FUR4_YEAST Uracil permeasegi|626971|pir||S45877 uracil transport protein - [nrdb_11152004_Chlamydomonas]
  • FUR4 SGDID:S000000225, Chr II from 281443-283344, Verified ORF, "Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • uracil permease [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues; Fur4p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Uracil permease [nr-271106-contam.fasta]
  • FUR4 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • uracil permease [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Uracil permease OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FUR4 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • FUR4 SGDID:S000000225, Chr II from 281443-283344, Genome Release 64-1-1, Verified ORF, "Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues" [yeast-030211-contam.fasta]
  • Uracil permease OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FUR4 PE=3 SV=2 [YEAST.fasta.20131015]
  • FUR4 SGDID:S000000225, Chr II from 281443-283344, Genome Release 64-2-1, Verified ORF, "Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation" [20141208_orf_trans.fasta]
  • YBR021W SGDID:S000000225, Chr II from 281443-283344, Genome Release 64-1-1, Verified ORF, "Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 633 amino acids

    Gene Ontology:
    Cellular Component: membrane raft [IDALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: uracil transport [IDALink to PubMed article]
    Molecular Function: uracil:cation symporter activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPDNLSLHLS GSSKRLNSRQ LMESSNETFA PNNVDLEKEY KSSQSNITTE VYEASSFEEK  60
   61 VSSEKPQYSS FWKKIYYEYV VVDKSILGVS ILDSFMYNQD LKPVEKERRV WSWYNYCYFW 120
  121 LAECFNINTW QIAATGLQLG LNWWQCWITI WIGYGFVGAF VVLASRVGSA YHLSFPISSR 180
  181 ASFGIFFSLW PVINRVVMAI VWYSVQAYIA ATPVSLMLKS IFGKDLQDKI PDHFGSPNAT 240
  241 TYEFMCFFIF WAASLPFLLV PPHKIRHLFT VKAVLVPFAS FGFLIWAIRR AHGRIALGSL 300
  301 TDVQPHGSAF SWAFLRSLMG CMANFSTMVI NAPDFSRFSK NPNSALWSQL VCIPFLFSIT 360
  361 CLIGILVTAA GYEIYGINYW SPLDVLEKFL QTTYNKGTRA GVFLISFVFA VAQLGTNISA 420
  421 NSLSCGTDMS AIFPKFINIK RGSLFCAAMA LCICPWNLMA TSSKFTMALS AYAIFLSSIA 480
  481 GVVCSDYFVV RRGYIKLTHI YSHQKGSFYM YGNRFGINWR ALAAYLCGVA PCLPGFIAEV 540
  541 GAPAIKVSDG AMKLYYLSYW VGYGLSFSSY TALCYFFPVP GCPVNNIIKD KGWFQRWANV 600
  601 DDFEEEWKDT IERDDLVDDN ISVYEHEHEK TFI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) FCY2 FUR4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..92] deduced N/A No confident structure predictions are available.
    2 View Details [93..578] Pfam 248.49485 Permease for cytosine/purines, uracil, thiamine, allantoin No confident structure predictions are available.
    3 View Details [579..633] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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