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Protein Overview: PRS4

General Information:
Name(s) found: PRS4 / YBL068W [SGD]
Description(s) found:
Found 10 descriptions.
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  • 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 355 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: 'de novo' pyrimidine base biosynthetic process [TASLink to PubMed article]
    tryptophan biosynthetic process [TASLink to PubMed article]
    'de novo' IMP biosynthetic process [TASLink to PubMed article]
    ribosome biogenesis [RCALink to PubMed article]
    histidine biosynthetic process [TASLink to PubMed article]
    purine ribonucleoside salvage [TASLink to PubMed article]
    Molecular Function: ribose phosphate diphosphokinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVIDLEHVVD YIMHIDSQLQ LHKASPAKMN SESREDMAIN SIKLLAGNSH PDLAEQISKK  60
   61 LGIPLSKVGV YQYSNKETSV TIGESLRDED VYIIQTGIGE QEINDFLMEL LILIHACQIA 120
  121 SARKITTVIP NFPYARQDKK DKSRAPITAK LVANLLQTAG ADHVITMDLH ASQIQGFFHI 180
  181 PVDNLYAEPS VLNYIRARKT DFDNAILVSP DAGGAKRVAA LADKLDLNFA LIHKERQKAN 240
  241 EVSKMVLVGD VTNKSCLLVD DMADTCGTLV KACDTLMEHG AKEVIAIVTH GIFSGSAREK 300
  301 LRNSRLSRIV CTNTVPVDLD LPIADQIDIS PTFAEAIRRL HNGESVSYLF THAPV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185]
    [330..355]    		 PSI-BLAST 781.54902 Phosphoribosylpyrophosphate synthetase
    2 View Details [186..329] PSI-BLAST 781.54902 Phosphoribosylpyrophosphate synthetase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle