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Protein Overview: ERD2

General Information:
Name(s) found: ERD2 / YBL040C [SGD]
Description(s) found:
Found 35 descriptions.
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  • HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 219 amino acids

    Gene Ontology:
    Cellular Component: integral to endoplasmic reticulum membrane [IDALink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [IMPLink to PubMed articleLink to PubMed article]
    protein retention in ER lumen [IGILink to PubMed article]
    Molecular Function: HDEL sequence binding [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNPFRILGDL SHLTSILILI HNIKTTRYIE GISFKTQTLY ALVFITRYLD LLTFHWVSLY  60
   61 NALMKIFFIV STAYIVVLLQ GSKRTNTIAY NEMLMHDTFK IQHLLIGSAL MSVFFHHKFT 120
  121 FLELAWSFSV WLESVAILPQ LYMLSKGGKT RSLTVHYIFA MGLYRALYIP NWIWRYSTED 180
  181 KKLDKIAFFA GLLQTLLYSD FFYIYYTKVI RGKGFKLPK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ERD2 SVP26

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ERD2 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..219] Pfam 156.638272 ER lumen protein retaining receptor No confident structure predictions are available.
    2 View Details [119..219] MSA 3.047991 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle