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Protein Overview: VPS8

General Information:
Name(s) found: VPS8 / YAL002W [SGD]
Description(s) found:
Found 10 descriptions.
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  • Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1176 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    Biological Process: late endosome to vacuole transport [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTSKGCVLI FNYNEHLQTI LVPTLSEDPS IHSIRSPVKS IVICSDGTHV AASYETGNIC  60
   61 IWNLNVGYRV KPTSEPTNGM TPTPALPAVL HIDDHVNKEI TGLDFFGARH TALIVSDRTG 120
  121 KVSLYNGYRR GFWQLVYNSK KILDVNSSKE KLIRSKLSPL ISREKISTNL LSVLTTTHFA 180
  181 LILLSPHVSL MFQETVEPSV QNSLVVNSSI SWTQNCSRVA YSVNNKISVI SISSSDFNVQ 240
  241 SASHSPEFAE SILSIQWIDQ LLLGVLTISH QFLVLHPQHD FKILLRLDFL IHDLMIPPNK 300
  301 YFVISRRSFY LLTNYSFKIG KFVSWSDITL RHILKGDYLG ALEFIESLLQ PYCPLANLLK 360
  361 LDNNTEERTK QLMEPFYNLS LAALRFLIKK DNADYNRVYQ LLMVVVRVLQ QSSKKLDSIP 420
  421 SLDVFLEQGL EFFELKDNAV YFEVVANIVA QGSVTSISPV LFRSIIDYYA KEENLKVIED 480
  481 LIIMLNPTTL DVDLAVKLCQ KYNLFDLLIY IWNKIFDDYQ TPVVDLIYRI SNQSEKCVIF 540
  541 NGPQVPPETT IFDYVTYILT GRQYPQNLSI SPSDKCSKIQ RELSAFIFSG FSIKWPSNSN 600
  601 HKLYICENPE EEPAFPYFHL LLKSNPSRFL AMLNEVFEAS LFNDDNDMVA SVGEAELVSR 660
  661 QYVIDLLLDA MKDTGNSDNI RVLVAIFIAT SISKYPQFIK VSNQALDCVV NTICSSRVQG 720
  721 IYEISQIALE SLLPYYHSRT TENFILELKE KNFNKVLFHI YKSENKYASA LSLILETKDI 780
  781 EKEYNTDIVS ITDYILKKCP PGSLECGKVT EVIETNFDLL LSRIGIEKCV TIFSDFDYNL 840
  841 HQEILEVKNE ETQQKYLDKL FSTPNINNKV DKRLRNLHIE LNCKYKSKRE MILWLNGTVL 900
  901 SNAESLQILD LLNQDSNFEA AAIIHERLES FNLAVRDLLS FIEQCLNEGK TNISTLLESL 960
  961 RRAFDDCNSA GTEKKSCWIL LITFLITLYG KYPSHDERKD LCNKLLQEAF LGLVRSKSSS1020
 1021 QKDSGGEFWE IMSSVLEHQD VILMKVQDLK QLLLNVFNTY KLERSLSELI QKIIEDSSQD1080
 1081 LVQQYRKFLS EGWSIHTDDC EICGKKIWGA GLDPLLFLAW ENVQRHQDMI SVDLKTPLVI1140
 1141 FKCHHGFHQT CLENLAQKPD EYSCLICQTE SNPKIV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..392] deduced N/A No confident structure predictions are available.
    2 View Details [393..588] Pfam 20.229148 Region in Clathrin and VPS No confident structure predictions are available.
    3 View Details [589..800] deduced N/A No confident structure predictions are available.
    4 View Details [801..1014] Pfam 13.585027 Region in Clathrin and VPS No confident structure predictions are available.
    5 View Details [1015..1176] MSA 2.035996 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.49

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle