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Protein Overview: CG30372-PB

General Information:
Name(s) found: CG30372-PB / FBpp0099488 [FlyBase]
Description(s) found:
Found 17 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG30372 (CG30372, FBgn0050372). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:4001791..4010357. It has the cytological map location 44B2. Based on sequence similarity, it is predicted to have molecular function</span>: ARF GTPase activator activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: small GTPase mediated signal transduction. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1155 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: small GTPase mediated signal transduction [ISS]
    regulation of ARF GTPase activity [IEA]
    Molecular Function: zinc ion binding [IEA]
    ARF GTPase activator activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPSLIAVSE FVEETRSDYS SPTTSTFASR MPDCRHTIGV LEERLEFDRE GLTKLKKAVK  60
   61 AIHNSGNTHV DNEMFMVRAL ERLGGKVIEQ DEPDIGAAFL KFSVVTKELS ALMKTLMQNI 120
  121 NNIVMFPVDS MLKSELRGVK GDMKRPFDKA AKDYEAKFIK IEKEKKAQAK EAGMVRTEID 180
  181 AAVVAEEMEK ERRLYQLQTC EYLLKYKDIK TKTGIELLQH LIEYYHALSN YFKDGLQTIE 240
  241 HFGTYIGDLS EKLHEIKQKQ DEDRRSLLDL RTVLRSTPDF ERVDNVPSSE SRSGGAGYSL 300
  301 HQLQGDKHHG VTRQGHLLKK SEGKVRRVWQ KRRCRVTSDG FLDIFHADES KPPTRVNLLT 360
  361 CQIKPVPDDK RGFDLISYNR PYHFQAEDEG DQKAWMAVLV NCKEKALTKA FQHANPQMSP 420
  421 SLVELQKTVI RYVQLLPGND RCCDCGSRND VTWISLNFGI LVCIQCSGVH RDLGVHHSRI 480
  481 QSLTLDNLTT ANLLIARAMG NSTLNDIMEA KLGRGKLQHE SSMEERYDFI RAKYVAKRYV 540
  541 MRTCSDDNDL RCDLEQAVVN ADMSQLLQVW AEGADLTCCL PSSDAGETAL HLAVLREMGS 600
  601 TLHIVDFLIQ NMPPKGLNKA TNPAGLLDVT GKNTALHLCA LHDRRECMKL LLRSGADYEL 660
  661 KNSQNKTALD IAKEMGHNSC RELIECAIKR EKSAFDHINT DWNLPNEDGS TDFSDDETVI 720
  721 DERKSRSRPP SFAGGDSPVL RSRSSTCDSI QSSSSPIANC PSRQFTLPSG LPSYTHSAGT 780
  781 SPKQHISVGQ YLGSATNVGG NGPGNGGSSP SSASSQSVRA ARNSLNMQSD LGGHVTGARK 840
  841 STSTANMNSL KKRTAPAPPP GTLGSASSSS FYGTLPHPPR HSQNFDASDI RAINHKNQSL 900
  901 DVAYGTLPHL RSVESSPRGG GGYGYGVSQD PGGSGNGSNN SLMPAMTTFG HKRSPSGESL 960
  961 NRNIHLAGAK LVLPPTGELP TLKHVDKSAL TRPKIPPPGP PSEREISNGQ SNESISSMDE1020
 1021 GPVAPPRKLV NQSANFPDYE SWHTDMDSSG GGLDHSAESN VSSSDNDRLN SSPDNPSKTG1080
 1081 GAGLGGKFHY NGQRRCRALY DCVADNDDEL EFKEGEILIV LNERTDDENW MEGIIEGQPT1140
 1141 RKGMFPVSFV HMLPD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..412] PSI-BLAST 55.69897 No description for 2elbA was found.
    2 View Details [413..719] PSI-BLAST 30.154902 Pyk2-associated protein beta; Pyk2-associated protein beta ARF-GAP domain
    3 View Details [720..789] PSI-BLAST 9.522879 53BP2
    4 View Details [790..968] deduced N/A No confident structure predictions are available.
    5 View Details [969..1036] deduced N/A No confident structure predictions are available.
    6 View Details [1037..1155] PSI-BLAST 13.221849 The solution structure of the fifth SH3 domain of intersectin 2 (KIAA1256)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.38944296108213 bayes_pls_golite062009
  • protein binding
    		•  1.8661085728568 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.37732998017634 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.35296416441022 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.982827080165016 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.948484673406212 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.476813178401925 bayes_pls_golite062009
  • small GTPase binding
    		•  0.258301158180693 bayes_pls_golite062009
  • GTPase binding
    		•  0.223470840486454 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • binding
    		•  2.16769365096483 bayes_pls_golite062009
  • protein binding
    		•  1.83074889220756 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle