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Protein Overview: Lerp-PB

General Information:
Name(s) found: Lerp-PB / FBpp0084467 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene lysosomal enzyme receptor protein is referred to in FlyBase by the symbol Dmel\Lerp (CG31072, FBgn0051072). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:22668184..22688843. It has the cytological map location 97D2-97D3. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: lysosomal transport; post-Golgi vesicle-mediated transport. 9 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 887 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IC][IEA]
    integral to membrane [IEA]
    Biological Process: lysosomal transport [IDA]
    post-Golgi vesicle-mediated transport [IDA]
    Molecular Function: protein binding [IPI]
    receptor activity [ISS]
    transporter activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRCSLQKDCA APTQENFRQQ MRFPIVISLL LLLFCSGESV AADAANQLKF STTECKLKEP  60
   61 IYGSTFDFSG LHSDLAHVVK SMNIGGDQFE FNICGNLSRT CNGESNVAAC LKRQGKEYIL 120
  121 GRQHELFYNN GNMFLKYKSG AKCDNGTADK PNYQLHVMFS CDYTLDAQPM HVTPYANEVC 180
  181 SFYISYRTPL ACLSIPEGLQ SNSCRVGDTK SNGTFDLMPL SDSNYHTSNR QGAFFVINVC 240
  241 KPVLYGENSM CPAGSSVCLF DSKATNPKER FINFGNVQTH PVVEKGQLLL RHESPTPCAK 300
  301 NSSANYTSVI YFSCDKFIRN AHPEFAGLGA DSCTYQFNFA TPLACNDLKP CTAFTSTNEL 360
  361 LDLSSLSSKP ARTLLKDGKN YTIAVCAHAG APCQENGGAC YEQNSTTISL GNSNSQLRFN 420
  421 QTGSLYLLYE DGAECSTATG MRRWSTKIEF VCANNATKDN GASTAGGSDS LKIIEDSNCQ 480
  481 LLIQYQTPLA CREPIRCKAT TYVDHTNDGL GSSGDELIDL TPLISATDNY EARVELPASM 540
  541 EHLVPKTTKF FLNVCRPLVP KYQLGCAGGS AACMAKVTAA GAPEEERSMG FPLVSLTQRN 600
  601 RTFAELAYLK GDPCPTDNTS ELSTHILFNC NMRAGRGQPV LRSVEDCAYR FEWETNVFCP 660
  661 PHECTFSADT CDLVHDELGR RFNFKSAPFT KDGKIEIDYN ATKMSVNICG AHRKAMTDYS 720
  721 QALVNIFFTH ESPNCGREGT MNVQIRLICS DQTESSSTIS SDQQCNLLYV QRTPSICEFL 780
  781 SLGATQQNFE SNGSTSSSTS SSSTSTTTST TTQASPAAIL GAILSVTFCV TCLGLLAFSP 840
  841 ARRQRIRRLF RRSNSAVRYS RVQSNEEANL LLEPNGEFTE SDDDMLL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..491] PSI-BLAST 61.045757 Crystal structure of N-terminal 3 domains of CI-MPR
    2 View Details [492..660] FFAS03 3.3 Cation-dependent mannose 6-phosphate receptor, extracytoplasmic domain
    3 View Details [661..887] PSI-BLAST 3.30103 Gelatinase A (MMP-2); Gelatinase A (MMP-2), C-terminal domain; Gelatinase A; Gelatinase A (MMP-2) type II modules

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein binding
    		•  1.28747861690557 bayes_pls_golite062009
  • binding
    		•  1.10138386107409 bayes_pls_golite062009
    3
    Term Confidence Notes
  • protein binding
    		•  0.873001869096005 bayes_pls_golite062009
  • binding
    		•  0.813983818243772 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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