Protein Overview: KCNQ-PE

General Information:
Name(s) found:	KCNQ-PE / FBpp0290658 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|56090093\|gb\|AAV70987.1\| potassium channel KCNQ [Drosophila melanogaster] [NCBI NR] gi\|56090091\|gb\|AAV70986.1\| potassium channel KCNQ [Drosophila melanogaster] [NCBI NR] The gene KCNQ potassium channel is referred to in FlyBase by the symbol Dmel\KCNQ (CG33135, FBgn0033494). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:6033402..6079899. It has the cytological map location 46F3-46F5. Based on sequence similarity, it is predicted to have molecular function</span>: voltage-gated potassium channel activity. There is experimental evidence that it is involved in the biological process</span>: embryonic development via the syncytial blastoderm; cardiac muscle contraction; regulation of heart rate. 28 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase] type=protein; loc=2R:complement(6033580..6033666,6033734..6033948,6034213..6034328,6034396..6034499,6034564..6034917,6034990..6035086,6035151..6035193,6035425..6035509,6035587..6035657,6038361..6038557,6040409..6040596,6040812..6040922,6040981..6041106,60 [fly-100309-contam.fasta] potassium channel KCNQ [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2R:complement(6033580..6033666,6033734..6033948,6034213..6034328,6034396..6034499,6034564..6034917,6034990..6035086,6035151..6035193,6035425..6035509,6035587..6035657,6038361..6038557,6040409..6040596,6040812..6040922,6040981..6041106,6041313..6041488,6041547..6041764,6041954..6042139,6042227..6042279); ID=FBpp0290658; name=KCNQ-PE; parent=FBgn0033494,FBtr0301443; dbxref=FlyBase_Annotation_IDs:CG33135-PE,FlyBase:FBpp0290658; MD5=45cedd9d5f537324b00bac684a42f581; length=808; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2R:complement(6033580..6033666,6033734..6033948,6034213..6034328,6034396..6034499,6034564..6034917,6034990..6035086,6035151..6035193,6035425..6035509,6035587..6035657,6038361..6038557,6040409..6040596,6040812..6040922,6040981..6041106,6041313..6041488,6041547..6041764,6041954..6042139,6042227..6042279); ID=FBpp0290658; name=KCNQ-PE; parent=FBgn0033494,FBtr0301443; dbxref=FlyBase_Annotation_IDs:CG33135-PE,FlyBase:FBpp0290658; MD5=45cedd9d5f537324b00bac684a42f581; length=808; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] KCNQ potassium channel, isoform E OS=Drosophila melanogaster GN=KCNQ PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=2R:complement(6033580..6033666,6033734..6033948,6034213..6034328,6034396..6034499,6034564..6034917,6034990..6035086,6035151..6035193,6035425..6035509,6035587..6035657,6038361..6038557,6040409..6040596,6040812..6040922,6040981..6041106,6041313..6041488,6041547..6041764,6041954..6042139,6042227..6042279); ID=FBpp0290658; name=KCNQ-PE; parent=FBgn0033494,FBtr0301443; dbxref=FlyBase_Annotation_IDs:CG33135-PE,FlyBase:FBpp0290658,REFSEQ:NP_788299,GB_protein:AAF58830,FlyMine:FBpp0290658,modMine:FBpp0290658; MD5=45cedd9d5f537324b00bac684a42f581; length=808; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2R:complement(join(10154722..10154774,10154449..10154634,10154042..10154259,10153808..10153983,10153476..10153601,10153307..10153417,10152904..10153091,10150856..10151052,10148082..10148152,10147920..10148004,10147646..10147688,10147485..10147581,10147059..10147412,10146891..10146994,10146708..10146823,10146229..10146443,10146075..10146161)); ID=FBpp0290658; name=KCNQ-PE; parent=FBgn0033494,FBtr0301443; dbxref=FlyBase_Annotation_IDs:CG33135-PE,FlyBase:FBpp0290658,REFSEQ:NP_788299,GB_protein:AAF58830,FlyMine:FBpp0290658,modMine:FBpp0290658; MD5=45cedd9d5f537324b00bac684a42f581; length=808; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2R:complement(join(10154722..10154774,10154449..10154634,10154042..10154259,10153808..10153983,10153476..10153601,10153307..10153417,10152904..10153091,10150856..10151052,10148082..10148152,10147920..10148004,10147646..10147688,10147485..10147581,10147059..10147412,10146891..10146994,10146708..10146823,10146229..10146443,10146075..10146161)); ID=FBpp0290658; name=KCNQ-PE; parent=FBgn0033494,FBtr0301443; dbxref=FlyBase_Annotation_IDs:CG33135-PE,FlyBase:FBpp0290658,REFSEQ:NP_788299,GB_protein:AAF58830,FlyMine:FBpp0290658,modMine:FBpp0290658; MD5=45cedd9d5f537324b00bac684a42f581; length=808; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Isoform of A1Z856, KCNQ potassium channel, isoform E OS=Drosophila melanogaster GN=KCNQ PE=2 SV=1 [DROME.fasta.20160308] FBpp0290658 type=protein; loc=2R:complement(join(10154722..10154774,10154449..10154634,10154042..10154259,10153808..10153983,10153476..10153601,10153307..10153417,10152904..10153091,10150856..10151052,10148082..10148152,10147920..10148004,10147646..10147688,10147485..10147581,10147059..10147412,10146891..10146994,10146708..10146823,10146229..10146443,10146075..10146161)); ID=FBpp0290658; name=KCNQ-PE; parent=FBgn0033494,FBtr0301443; dbxref=FlyBase_Annotation_IDs:CG33135-PE,FlyBase:FBpp0290658,REFSEQ:NP_788299,GB_protein:AAF58830,FlyMine:FBpp0290658,modMine:FBpp0290658; MD5=45cedd9d5f537324b00bac684a42f581; length=808; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2R:complement(join(10154722..10154774,10154449..10154634,10154042..10154259,10153808..10153983,10153476..10153601,10153307..10153417,10152904..10153091,10150856..10151052,10148082..10148152,10147920..10148004,10147646..10147688,10147485..10147581,10147059..10147412,10146891..10146994,10146708..10146823,10146229..10146443,10146075..10146161)); ID=FBpp0290658; name=KCNQ-PE; parent=FBgn0033494,FBtr0301443; dbxref=FlyBase_Annotation_IDs:CG33135-PE,FlyBase:FBpp0290658,REFSEQ:NP_788299,GB_protein:AAF58830,UniProt/TrEMBL:Q5PXF9,FlyMine:FBpp0290658,modMine:FBpp0290658; MD5=45cedd9d5f537324b00bac684a42f581; length=808; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	808 amino acids
Gene Ontology:
Cellular Component:	voltage-gated potassium channel complex [IEA] integral to membrane [ISS]
Biological Process:	potassium ion transport [ISS] regulation of heart rate [IMP] transmembrane transport [IEA] embryonic development via the syncytial blastoderm [IMP] cardiac muscle contraction [IMP]
Molecular Function:	voltage-gated potassium channel activity [ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPDNDIYAF YDIRGYKGKC RPGRPNSERI LQPRMSLLGK PLNYNRGTRR DVRYRRLQSR  60
   61 LYNFLERPRG LHAIFYHVMV FLMVFTCLAL SVFSTIKEYE EDAVYILFRM EILVVIWFTM 120
  121 EFGARLWSSG CRSRYQGCLG RLKFVKRPFC IIDIVTILAS IVVLGMGTSG QVFATSALRG 180
  181 LRFFQILRMV RMDRRGGTWK LLGSVVYAHR QELITTMYIG FLGLIFASFL VYMWEKDVND 240
  241 KFSNFAQALW WGVITLCTVG YGDMVPITWQ GKLIASCCAL LGISFFALPA GILGSGFALK 300
  301 VQQQQRQKHM IRRRQPAATL IQAVWRCYAA DEHSVSVATW NIHRVALPSP PASRASSSFK 360
  361 HNTSFVARLP TIRRHKSQTI QTPGGGDGGG VSKPPGSSRA STRYTRTIRD INASVENLDE 420
  421 EDEPRCTQLT NRHKTAIRFI RKLKYFVARR KFKEALKPYD VKDVMEQYAA GHVDLLGRVK 480
  481 MLHLRLDQIL GKQGSKAKDV YASKISLASR VVKVERQVAD IEEKLDILIK AYMEDRDRFL 540
  541 ALPLPAKPKI HSISPSHKPL HHAHNLAMID VWKRTAALSV HPEQVTTTPL LNPSAPDSSE 600
  601 LRSLTATQTP TTTTDAIATQ TPMPPHVQHT ATNTKSSVLN SYQLGSEKQQ HNDVFMTELE 660
  661 NRTKKRVTLS LHRSTSEPYS KQEQRITIPD EGADSLDSSA KPTPPDSSII LIDEYEDFEE 720
  721 EDLNCEGEMD HFPTWEIDSD IGVEVDVDAD ADGDCDESTE DTALLQCATR TAIVITPISP 780
  781 VSSAHNLQQL NDQTTTLNKS NLLPPDSG

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: KCNQ-PE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: