Protein Overview: CDK12_RAT

General Information:
Name(s) found:	CDK12_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|76563916\|ref\|NP_001029039.1\| Cdc2-related kinase, arginine/serine-rich isoform 1 [Rattus norvegicus] [NCBI NR] gi\|65306214\|gb\|AAY41734.1\| cyclin-dependent kinase 12 isoform [Rattus norvegicus] [NCBI NR] gi\|123780808\|sp\|Q3MJK5.1\|CD2L7_RAT RecName: Full=Cell division cycle 2-related protein kinase 7; Short=CDC2-related protein kinase 7; AltName: Full=Cdc2-related kinase, arginine/serine-rich; Short=CrkRS; AltName: Full=Cyclin-dependent kinase 12; AltName: [NCBI NR] Cyclin-dependent kinase 12 OS=Rattus norvegicus GN=Cdk12 PE=1 SV=1 [Swiss-Prot] Cell division cycle 2-related protein kinase 7 OS=Rattus norvegicus GN=Crkrs PE=1 SV=1 [Swiss-Prot] Tax_Id=10116 CDC2-related kinase 7 isoform 1 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Tax_Id=10116 Cyclin-dependent kinase 12 isoform [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta] Cell division cycle 2-related protein kinase 7 (CDC2-related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cyclin-dependent kinase 12) (Protein kinase for splicing component) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] CDC2-related kinase 7 isoform 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] cyclin-dependent kinase 12 isoform [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Cdc2-related kinase, arginine/serine-rich isoform 1 [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Crkrs Isoform 1 of Cell division cycle 2-related protein kinase 7 [rat-ipi-250309-contam.fasta] cell division protein kinase 12 isoform 1 [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] Isoform 1 of Cell division protein kinase 12 OS=Rattus norvegicus GN=Cdk12 [011711_HMR.fasta] Isoform 1 of Cyclin-dependent kinase 12 OS=Rattus norvegicus GN=Cdk12 [120808_122_R_norvegicus.fasta]
Organism:	Rattus norvegicus
Length:	1484 amino acids
Gene Ontology:
Cellular Component:	nucleus [UNKNOWN][IEA] nuclear speck [IEA]
Biological Process:	protein amino acid autophosphorylation [UNKNOWN][IEA]
Molecular Function:	nucleotide binding [IEA] ATP binding [IEA] protein kinase activity [UNKNOWN] cyclin-dependent protein kinase activity [IEA] transferase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNSERHGGK KDGSGGASGT SQPSSGGGSS NSRERHRLVS KHKRHKSKHS KDMGLVTPEA  60
   61 ASLGTIIKPL VEYDDISSDS DTFSDDMAFK SDRRENDERR GTDRSDRLHR HRHHQHRRSR 120
  121 DLLKTKQTEK EKNQEVSKSG SMKDRLSGSS KRSVEGNDDY GKAQLSKSSS KESRSSKMHK 180
  181 EKTRKERELK SGHKDRSKSH RKRETPKSYK TVDSPKRRSR SPHRKWSDSS KQDDSPSGAS 240
  241 YGQDYDLSPP RSHTSSNYDS YKKSPGSTSR RQSISPPYKE PSAYQSSTRS PSPYSRRQRS 300
  301 VSPYSRRRSS SYERSGSYSG RSPSPYGRRR SSSPFLSKRS LSRSPISSRK SMKSRSRSPA 360
  361 YSRHSSSHSK KKRSGSRSRH SSISPVRLPL NSSLGAELSR KKKERAAAAA AAKLDGKESK 420
  421 GSPIILPKKE KFEVKESGLE SKKLPRGIKS EKSTPDTELV NVAHSNTEVK NCLDTGKVKL 480
  481 DENLQKHPVK DLKAQGTKDT KPVALKEVIV TSKETETSEK EALPPLPTIT SPPPLPSTTP 540
  541 PPQTPPLPPL PPLPAVPLQP PLPPPQPPFS QVPVSNTSTL PSSPHPRTST LSSQTNSQPL 600
  601 VQVSMKTQLS VTAAIPHLKT STLPPLPLPP LLPGDDDMDS PKEMLPSKPA KKEKEQRTRH 660
  661 LLTDLPLPPE LPGGDPSPPD SPEPKAITPP QQPYKKRPKI CCPRYGERRQ TESDWGKRCV 720
  721 DKFDIIGIIG EGTYGQVYKA KDKDTGELVA LKKVRLDNEK EGFPITAIRE IKILRQLVHQ 780
  781 SVVNMKEIVT DKQDALDFKK DKGAFYLVFE YMDHDLMGLL ESGLVHFSED HIKSFMKQLM 840
  841 EGLDYCHKKN FLHRDIKCSN ILLNNSGQIK LADFGLARLY NSEESRPYTN KVITLWYRPP 900
  901 ELLLGEERYT PAIDVWSCGC ILGELFTKKP IFQANLELAQ LELISRLCGS PCPAVWPDVI 960
  961 KLPYFNTMKP KKQYRRRLRE EFSFIPSAAL DLLDHMLTLD PSKRCTAEQT LQSDFLKDVE1020
 1021 LSKMAPPDLP HWQDCHELWS KKRRRQRQSG IVIEEQPPSK ASRKETTSGT AAEPVKNSSP1080
 1081 APPQPAPVKA EPGPGDAVGL GDITQQLNQS ELAVLLNLLQ SQTDLSIPQM AQLLNIHSNP1140
 1141 EMQQQLEALN QSISALTEAS SQQQDSESIA PEESLKEVPS VSVVLPPAEQ TTPEASNTPA1200
 1201 DMQNMLAVLL SQLMKTQEPA GNLEENTSDK NSGPQGPRRT PTMPQEEAAA CPPHILPPEK1260
 1261 RPPEPPGPPP PPPPPPLVEG DLSSAPQELN PAVTAALLQL LSQPEAEPPG HLPHEHQALR1320
 1321 PMEYSTRSHP NRTYGNTDGP ETGFSATDTD ERSSGPALTE SLVQTLVKNR TFSGSVSHLG1380
 1381 ESNSYQGTGS VQFPGDQDLR FTRVPLALHS VVGQPFLKSE GNSNSVVHAE TKLQNYGELG1440
 1441 PGTTGANSSG TTLQWGGPAQ SFGKPYRGAA RVPPRGGRGR GVPY

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: CDK12_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: