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Protein Overview: daf-12

General Information:
Name(s) found: daf-12 / CE39240 [WormBase]
Description(s) found:
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  • WBGene00000908 locus:daf-12 status:Confirmed UniProt:Q2XN07 protein_id:CAJ43436.1 [WormBase]
  • gi|82465306|emb|CAJ43436.1| C. elegans protein F11A1.3d, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|115533432|ref|NP_001041239.1| abnormal DAuer Formation family member (daf-12) [Caenorhabditis elegans] [NCBI NR]
  • CE39240 WBGene00000908 locus:daf-12 status:Confirmed UniProt:Q2XN07_CAEEL protein_id:CAJ43436.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE39240 WBGene00000908 locus:daf-12 status:Confirmed UniProt:Q2XN07_CAEEL protein_id:CAJ43436.1| [wormORF-contam.fasta]
  • CE39240 WBGene00000908 locus:daf-12 status:Confirmed TR:Q2XN07 protein_id:CAJ43436.1 [wormpep160-contam.fasta]
  • Hypothetical protein F11A1.3d [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • abnormal DAuer Formation family member (daf-12) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE39240 WBGene00000908 locus:daf-12 status:Confirmed UniProt:Q2XN07 protein_id:CAJ43436.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • Isoform of G5EFF5, Isoform d of Nuclear hormone receptor family member daf-12 OS=Caenorhabditis elegans GN=daf-12 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 719 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: negative regulation of multicellular organism growth [IMPLink to PubMed articleLink to PubMed article]
    regulation of development, heterochronic [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    transcription factor activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    steroid hormone receptor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]
    steroid binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADNLLSSQN YINWTMLNKF YGKPQMSTPD DPVIHSPPSI GAAPGMNGYH GSGVKLEESS  60
   61 GACGSPDDGL LDSSEESRRR QKTCRVCGDH ATGYNFNVIT CESCKAFFRR NALRPKEFKC 120
  121 PYSEDCEINS VSRRFCQKCR LRKCFTVGMK KEWILNEEQL RRRKNSRLNN TGTCNKRSQP 180
  181 GNQQSPQGPN QQPHLSPHHP GVAIYPPQPQ RPLTINPMDN QMMHHMQANR PNAMPQLISP 240
  241 PGAQPYPLTS PVGSSASDSP PNRSLTMMHN GEKSPDGYDP NIMAHRAPPP SFNNRPKMDS 300
  301 GQVVLSTEEY KQLLSRIPGA QVPGLMNEEE PINKRAAYNC NGHPMPAETT PPYSAPMSDM 360
  361 SLSRHNSTSS GTEKNHMTHS TVSAIPGNSA QNHFDIASFG MGIVTATGGG DAAEEMYKRM 420
  421 NMFYENCIQS ALDSPENQEP KPQEAMIPKE EYMTPTHGFQ YQSDPYQVPP AERNINYQLN 480
  481 AAELKALDAV REAFYGMDDP MEQGRQMQSF LKANKTPADI MNIMDVTMRR FVKVAKGVPA 540
  541 FREVSQEGKF SLLKGGMIEM LTVRGVTRYD ASTNSFKTPT IKGQNVSVNV DDMFAKLNAN 600
  601 AQAQKAKCLE FFGFFDEEIK KNELAVYLVM LAVLFSVRSD PPMNENDVRI VTERHNHFMS 660
  661 LLNRYLESLF GEQARRIFER IPKALGLLNE IARNAGMLFM GTVRSGEAEE LPGEFFKIK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..177] PSI-BLAST 26.522879 Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
    2 View Details [178..379] deduced N/A No confident structure predictions are available.
    3 View Details [380..719] PSI-BLAST 45.69897 hemipteran ecdysone receptor ligand-binding domain complexed with ponasterone A


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle