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Protein Overview: tph-1

General Information:
Name(s) found: tph-1 / CE39458 [WormBase]
Description(s) found:
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  • WBGene00006600 locus:tph-1 status:Confirmed UniProt:Q2V4U7 protein_id:CCD65930.1 [WormBase]
  • gi|82654553|gb|ABB88222.1| Tryptophan hydroxylase protein 1, isoform b [Caenorhabditis elegans] [NCBI NR]
  • gi|115532103|ref|NP_001022504.2| TryPtophan Hydroxylase family member (tph-1) [Caenorhabditis elegans] [NCBI NR]
  • CE39458 WBGene00006600 locus:tph-1 status:Confirmed UniProt:Q2V4U7_CAEEL protein_id:ABB88222.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE39458 WBGene00006600 locus:tph-1 status:Confirmed UniProt:Q2V4U7_CAEEL protein_id:ABB88222.1| [wormORF-contam.fasta]
  • CE39458 WBGene00006600 locus:tph-1 status:Confirmed TR:Q2V4U7 protein_id:ABB88222.1 [wormpep160-contam.fasta]
  • Tryptophan hydroxylase protein 1, isoform b [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • TryPtophan Hydroxylase family member (tph-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE39458 WBGene00006600 locus:tph-1 status:Confirmed UniProt:Q2V4U7 protein_id:ABB88222.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • CE39458 WBGene00006600 locus:tph-1 status:Confirmed UniProt:Q2V4U7 protein_id:CCD65930.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • Isoform of G5EED8, TryPtophan Hydroxylase OS=Caenorhabditis elegans GN=tph-1 PE=4 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 429 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IDALink to PubMed article]
    Biological Process: serotonin biosynthetic process [IEALink to PubMed article]
    regulation of pharyngeal pumping [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    lipid storage [IMPLink to PubMed article]
    dauer larval development [IGILink to PubMed article][IMPLink to PubMed article]
    aromatic amino acid family metabolic process [IEALink to PubMed article]
    L-phenylalanine catabolic process [IEALink to PubMed article]
    regulation of oviposition [IMPLink to PubMed article]
    determination of adult lifespan [IGILink to PubMed article][IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    catecholamine biosynthetic process [IEALink to PubMed article]
    serotonin biosynthetic process from tryptophan [IMPLink to PubMed article][ISSLink to PubMed article]
    positive regulation of transforming growth factor beta receptor signaling pathway [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: iron ion binding [IEALink to PubMed article]
    phenylalanine 4-monooxygenase activity [IEALink to PubMed article]
    monooxygenase activity [IEALink to PubMed article]
    tyrosine 3-monooxygenase activity [IEALink to PubMed article]
    tryptophan 5-monooxygenase activity [IEALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIANLPDHTR IKHLETRDSQ DGSSKTMDVL LEIELFHYGK QEAMDLMRLN GLDVHEVSST  60
   61 IRPTAIKEQY TEPGSDDATT GSEWFPKSIY DLDICAKRVI MYGAGLDADH PGFKDTEYRQ 120
  121 RRMMFAELAL NYKHGEPIPR TEYTSSERKT WGIIYRKLRE LHKKHACKQF LDNFELLERH 180
  181 CGYSENNIPQ LEDICKFLKA KTGFRVRPVA GYLSARDFLA GLAYRVFFCT QYVRHHADPF 240
  241 YTPEPDTVHE LMGHMALFAD PDFAQFSQEI GLASLGASEE DLKKLATLYF FSIEFGLSSD 300
  301 DAADSPVKEN GSNHERFKVY GAGLLSSAGE LQHAVEGSAT IIRFDPDRVV EQECLITTFQ 360
  361 SAYFYTRNFE EAQQKLRMFT NNMKRPFIVR YNPYTESVEV LNNSRSIMLA VNSLRSDINL 420
  421 LAGALHYIL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..429] PSI-BLAST 159.0 Phenylalanine hydroxylase N-terminal domain; Phenylalanine hydroxylase, PAH

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
    		•  5.95179224585512 bayes_pls_golite062009
  • tyrosine 3-monooxygenase activity
    		•  5.29200621320545 bayes_pls_golite062009
  • acetolactate synthase activity
    		•  3.23518662935565 bayes_pls_golite062009
  • tryptophan 5-monooxygenase activity
    		•  2.77661203376054 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  2.5269324625528 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  2.14478023783883 bayes_pls_golite062009
  • monooxygenase activity
    		•  1.6613930139243 bayes_pls_golite062009
  • binding
    		•  1.10693426788511 bayes_pls_golite062009
  • catalytic activity
    		•  0.932947046865376 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.699576439508937 bayes_pls_golite062009
  • protein binding
    		•  0.431526081681418 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle