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View Structure Prediction Details

Protein: tph-1
Organism: Caenorhabditis elegans
Length: 429 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tph-1.

Description E-value Query
Range
Subject
Range
gi|114636422 - gi|114636422|ref|XP_001172877.1| PREDICTED: hypothetical protein isoform 3 [Pan troglodytes]
614.0 [0..8] [427..42]

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Predicted Domain #1
Region A:
Residues: [1-429]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIANLPDHTR IKHLETRDSQ DGSSKTMDVL LEIELFHYGK QEAMDLMRLN GLDVHEVSST  60
   61 IRPTAIKEQY TEPGSDDATT GSEWFPKSIY DLDICAKRVI MYGAGLDADH PGFKDTEYRQ 120
  121 RRMMFAELAL NYKHGEPIPR TEYTSSERKT WGIIYRKLRE LHKKHACKQF LDNFELLERH 180
  181 CGYSENNIPQ LEDICKFLKA KTGFRVRPVA GYLSARDFLA GLAYRVFFCT QYVRHHADPF 240
  241 YTPEPDTVHE LMGHMALFAD PDFAQFSQEI GLASLGASEE DLKKLATLYF FSIEFGLSSD 300
  301 DAADSPVKEN GSNHERFKVY GAGLLSSAGE LQHAVEGSAT IIRFDPDRVV EQECLITTFQ 360
  361 SAYFYTRNFE EAQQKLRMFT NNMKRPFIVR YNPYTESVEV LNNSRSIMLA VNSLRSDINL 420
  421 LAGALHYIL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 159.0
Match: 1phzA
Description: Phenylalanine hydroxylase N-terminal domain; Phenylalanine hydroxylase, PAH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen 5.95179224585512 bayes_pls_golite062009
tyrosine 3-monooxygenase activity 5.29200621320545 bayes_pls_golite062009
acetolactate synthase activity 3.23518662935565 bayes_pls_golite062009
tryptophan 5-monooxygenase activity 2.77661203376054 bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups 2.5269324625528 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 2.14478023783883 bayes_pls_golite062009
monooxygenase activity 1.6613930139243 bayes_pls_golite062009
binding 1.10693426788511 bayes_pls_golite062009
catalytic activity 0.932947046865376 bayes_pls_golite062009
oxidoreductase activity 0.699576439508937 bayes_pls_golite062009
protein binding 0.431526081681418 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle