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Protein Overview: FBpp0311921, hiw-PA

General Information:
Name(s) found: FBpp0311921 [FlyBase]
hiw-PA / FBpp0073787 [FlyBase]
Description(s) found:
Found 23 descriptions.
SHOW ALL
  • type=protein; loc=X:complement(14904865..14905354,14905422..14905615,14905676..14906140,14906207..14906548,14906650..14908008,14908065..14909366,14909442..14909923,14909988..14911974,14912156..14912771,14912845..14912958,14945891..14946026,14946090..14946192,14946254..14946401,14946461..14949008,14949072..14949350,14949404..14950451,14950510..14951069,14951133..14951272,14951335..14952034,14952098..14953217,14953384..14953770,14953966..14955076,14957055..14957125); ID=FBpp0311921; name=hiw-PB; parent=FBgn0030600,FBtr0346087; dbxref=FlyBase:FBpp0311921,FlyBase_Annotation_IDs:CG32592-PB; MD5=5bd4864aae87a1d69d597f7cdd9e4690; length=5233; release=r5.56; species=Dmel; [FlyBase]
  • The gene highwire is referred to in FlyBase by the symbol Dmel\hiw (CG32592, FBgn0030600). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:14904716..14957440. It has the cytological map location 13A5-13A8. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of synaptic growth at neuromuscular junction; negative regulation of BMP signaling pathway; BMP signaling pathway; regulation of synaptic growth at neuromuscular junction. 64 alleles are reported. The phenotypes of these alleles are annotated with: bouton; terminal button; neuromuscular junction; motor neuron; larval neuromuscular junction; indirect flight muscle motor neuron MN4; synapse; synaptic vesicle. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 5233 amino acids

    Gene Ontology:
    Cellular Component: anaphase-promoting complex [IEA]
    cytoplasmic membrane-bounded vesicle [IDA]
    plasma membrane [IDA]
    Biological Process: negative regulation of BMP signaling pathway [IGI]
    adult walking behavior [NAS]
    regulation of mitotic metaphase/anaphase transition [IEA]
    locomotion [NAS]
    regulation of synaptic growth at neuromuscular junction [IMP][TAS]
    BMP signaling pathway [IPI]
    negative regulation of synaptic growth at neuromuscular junction [IMP]
    protein ubiquitination [ISS]
    Molecular Function: ubiquitin-protein ligase activity [ISS]
    zinc ion binding [IEA]
    protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVGLLNPLKY GDHFYELYTN STRRKMQHDR KVLTKRKSRK DKSAAAMAAA AAAAVLEGNA  60
   61 GAGGLVNPLD PPLVKEQLMI LPSFPVAHIE LDPNASKFAV FSAIRSTVLE AETRYSLFQE 120
  121 GGAPSGQSGS NQKKWSNNVN SACCMMCAHS CMISNLLDCS CHAHMAMHGA VGPGNAGPGG 180
  181 PVGVLVDGRI PAPVPVVVGG PGLPAEKRPR RDSANSDADS DTEEPTEREP VYATVPLIVG 240
  241 AGLRSLFELI ADARHVHPLL CTKALKALLD VIQGQQPESF KLEPEELINP LYDLLLDLAT 300
  301 MPAALNSATG AEANWSAMAC AALLGLCIAR GDTGKMLKAI AAMLMTPRQL SAQIVQLPVV 360
  361 LATLQHTVIS AALNKPTRPD FHSHGVPHNS LIDEFPVKLP PLSTGAPITS PAMACDGVFV 420
  421 YLLYGGTLLK IGTGFGGSYK GHIYAQNEDF SHERSAWLGY SGGQLYFRRT CRRSAGDQLQ 480
  481 MVGLDTLAIK AMSPLSMLHM REGLNYVLFT DDDSLHAICS NRDDTLVVKK LNLYHNSYNI 540
  541 DPPPFELPLQ LARKKFRTLG YAAFEDELLN QYQIQRIQSA HNSFEPKLPA PCRDADVDVM 600
  601 GMACGKEFGL VRASNGRVYY YGKSAALGLK CVGRTPTLKL TELVISKAAN IVHVAVGHDG 660
  661 IHALLVNDDG TVFFAGTARR GEDGDSSKNR RQPKAVKPKK MTKIDGHVVV HAACNNGTSA 720
  721 FVTKTGKLIM YGKDTAHCDA MGFVSELLEQ HVTKVALGKA HCVALNAKGQ LFSFGLNNKG 780
  781 QCGRIFNKLQ PVKDVPPFAS SSTAAACFAS LLPLDKRLKL DFSTLCDYDD HNLVQGQCRV 840
  841 CVICRECTGY NVSCVSALNV PLDQRLAGSI CPCGHGDAGC AKCGLCAACI ALQDSDEAKT 900
  901 ELKPPPSDVQ QRQQRSKTLI MRRKERKGEL ETGAAGGGAA TPTDLDKDPP RVAPLAPQLL 960
  961 QLTSSSPVVQ VACGLHHTVV LTLAGEVYTF GSNQYGQLGS GDLQPVSGPV RVQVPGAISQ1020
 1021 VAAGSNHTVL LTSKGMVYTF GNYQKGQLGR LPSDYGLKPP PQDDDSPVGA GSDGGAGGSP1080
 1081 TVAPVGMPGP ERSQSPANVQ PSGSKEMPPL LPVLTQRQKF LWNCSPGAVF GLGPCYGKKV1140
 1141 TWIGANGDQT FIKIDESLIT AQMLPKMHVV ANKKTILLIP SIPLSFHTLS INRRDGSCTA1200
 1201 HYRGQTNFVK LMQAQPEQQQ PEINSNLDVA VTPVADSPAH ASTSSLLAAL TGTATAGVPI1260
 1261 NEQMSRSMHE ARNQIFEEQL PEVGSSAAAA AVAAPGTPVS AGSVPRSRRG GKQGTSSPEP1320
 1321 IPSPPQLAFT MDPTYNVLWV FDGAARKLRC HNVVASDIND SDANAATYRS LLSPELSLPD1380
 1381 RVDSRVARSQ ASLNLLACLD ILTSAQDNIP GCFEQPLLKQ TQQTAETQAG EFQVVNRFDN1440
 1441 FGGGWGYSGH SVEAIRFSAD TDIVICGFGM FGGRGEYSCK LKLFDLGGDG GGYEKEGILI1500
 1501 SETKEVPYEC GARSKHHILL PKPVSAVAGR WYLVWARIAG PSSDCGSCGQ ASVTTEDQVV1560
 1561 FSFKSSKKAN NGTDVNSGQI PAILYRLVTQ DCKQTPAQMD ADPVQRISRA FANSVSRECF1620
 1621 ESLVVLLSWS WDCFKLQLRE ERDRSRPLQL QQSLQYLGYV IKSCLRLLRK YTIEIYPQRN1680
 1681 SSTSVATGGG SNAAHGSGVV TTAKSVQSKP NKDKNTPRVV GNAGVMAKYF GDPSTSVAPA1740
 1741 MISSASSGGA PSTSASAAVA PGSGTPVTRK TNMENIQLAE CIGNVRALLI GIFCDDIFKD1800
 1801 IATDEGYELS LEILDECHLS FVACFDAFYP TSSLKWNCLC DLLAQMDRGA LHSRLLSAIL1860
 1861 AGLCSPSVKL RATFSLLSAA GNERQSIISP SDNSGLPMLS STDAHPYPVL VEQMIYRTQQ1920
 1921 EKSDFLSNSW TFKDVLVRLL DIIASPIRSR IEAIYSRSLG SLGYPGGKDC VNQGLIDNCC1980
 1981 HLLARVLAEI VYQTAMGEYD KLFMPPRTLH STGARFARCD VSRTWNTGNF GPDAIAFAVD2040
 2041 RPGVAIAGAM VYSGSGSYDY QLELLYDNTA DLQPQHKWET LESVSGSYDQ DAVHNDLAEI2100
 2101 KFDHPVHIKE NARYALRLCS QGARTCSGDA GMPAVRGPCG AQFHFYACDL SFNGTTPARG2160
 2161 QLPCILYYST PMKQDGHSAS GRTGDGSNVA THLEDRIMLL GPHEVSTRDT ALQIAADITK2220
 2221 KCTELLILAR NAMAASCSPS DNSSNHTQTI DSEHNITPIE EHMDINWANN SRTAALPTAI2280
 2281 DPQLSTARDL GKRIESFSKG LMETLKFDKR STNPFEMEIE IGATEVEESA DLRNGQSQSV2340
 2341 SQSQSQSQSV PINGNERTAD FEFAEQSAQQ SMPQHLHSDS EEAPLEVAGM AAGGGVSVAD2400
 2401 GSGGVAGVGS QAAAVQLLEV FNLAASNMFH TLLPLVYAHI ANLACSDPKS SVQILGLIKE2460
 2461 ILPHIAALNQ LHVSKDQRQP EPAIFATQTS GSGNSNSSST TSNHYCVVES DHPYKSASIS2520
 2521 SYRVEFPPCV QWLTIEFDPQ CGTAQLEDYL LLSIPMRPAS QAPPVPHVDD YLEQADNNVN2580
 2581 GAGDRRRNTG GGIAGSGAAP NTHQRSASVQ LTMASCCRSP GCGNAPGSAA APSSMPLRSQ2640
 2641 DPNDREWIVV KKFNTASTWL HNVLILPGNC VEFSLETASL YAQDPHNNRY GFKCLVVGYD2700
 2701 NPTSINASNS CLIRLEQELA YLGGMCSANL MKKELNLPDD KDVEDMSGIE ETINTHHTLL2760
 2761 SKGFALSEPQ LTVHQALESY LPIGSQSNER QFLKDFISGA PGSSGARLAA WLQPESRLDP2820
 2821 NKCELNTITE PLRYGWPSQV TVTIRDQYGD AVLVPELKVE IKAIPTGSGP NGSATGTGTS2880
 2881 CTSVAEVSAP GPNLWMRRAS RDTWGWGGMA PPPRINYEPT VKDKMVFKAI TFMKPYANYS2940
 2941 FEELRYASPV QTRVTELLNA KDMEDGTFSV QWTPSSVGAY CLAVTIDGIP LEEVYRVDVK3000
 3001 EGILPPPTQR NSAQRRPQAP SKLRRFQARH SSGLRIRSHP TLQSEQVGVV RVGGVISFID3060
 3061 EIENDDGVWL RLSTESIRQH CTMGWYPTEA WCLQFNQHLA RMLLQPVTDK EVNPVRKGVG3120
 3121 AEEDVEEQPP VTPSASGEAS PEPEPDPSPV LSPAKTKPGR FLSGHQSTNP FLYPAKHADL3180
 3181 AEREAQVQEE REKEEEQVDD EDADDREPEQ EALPAVELLP AHIGSAIAGV VGGGAIKLQA3240
 3241 LQKWFKGDAV DGPQPLTPSH SPPLAGVSVR ELVRAMGGQD SPRGNGNRSQ QEQDPEFSLA3300
 3301 SMRRPNYSAS QTAALLSTPK HTPKRSAVVA SETSGLEDEL SLLQITTTTT GQGEQQSELQ3360
 3361 LATTSTASSA SKRNPMGPIK RAMPPSFAES IRAVFAALLW HEGVVHDAMA CASFLKFHPG3420
 3421 LPKEGATVVT RRGESGDPRL QLSREQKAQQ RHSVEVANAG NYLNIRPSTL ETLTKSGNCS3480
 3481 LHNRSKYRKN LLSGGGGAIN SGDDTAQKLQ ALPEMVSVLP PALRCLVYLW EQICSGCVQI3540
 3541 VQSNALEQRE PRLLSPGSRD LNGDADTEGK EGKNSDQASA GEKDLGRKCK RKKKDDGSWC3600
 3601 EICELFLPMP VTYHMRIAHP GCGKSAKGKG YNSVGIFCEG WAGNCGEGGK GASSWFLMCD3660
 3661 PCRDRYLASC RSANNINSAA RQLESSAAEG NELNLFGVKS TTLIANAEVY TTMRENATFL3720
 3721 LELCSSSSSA SGAAGSLAAT SSSSKRSPQQ MSVVAMPVVI EHQLGNSDLK PSTSRCSRMA3780
 3781 RLSGSKFCPG VGSGAFRKSF VGGPPTAPEN VWLAPESFAC LECLGTAGHE DLPYEMFGLG3840
 3841 PNSNDNGYDR PLSEISYESC EPNNYDMLSG SLAPGTTAAA SVGGGNLSKF HRSYSMGQGW3900
 3901 ASLAQHNHPP PHHPQQQHHQ QQQMNLQLQQ HQAPPVDGQP KVVYRRRNNS TSEGDGSLLI3960
 3961 CYPSEHLRRL VPQKLLASVS VMQTASGEGT GKDHATGTLG LDQSAGQNGG GNLLLTRPAM4020
 4021 AFITQKHELD RLRAAMRRSL RIAACRIYAL QALNWLLRSV TQGVCLHDLM WWFVSSLNPT4080
 4081 GGHQPVERGE EASEPALEHP VAYTQISGRF AHLITQSLHV FLQSVADLTL HLPLGSPLQR4140
 4141 VAIQCFGIRF RQADHQFLHS SHVFGNISKI LSKSDEQNDA MAVSTILKPD CDVEHNQVHS4200
 4201 VATGGSSGAG ARLLCYTDLA GMFEVTVSSR PAMAESLTDN STETFWESDE EDRNKCKIIE4260
 4261 LSLTKLNYAC RYLLVHIDNS RDIQNKVLNV VFYAGQSLGD TNIIKSADVD PKACSWISAK4320
 4321 ICDDSCTHFR LELHGPENTL RVRQIKLLGL PIGGAVGSDD SSDHKHQPHL RLSHASRIQQ4380
 4381 QICEAETLRV FRLITGQVFG KLISNVSSDL VPPDSAGIGP PSGGAASTSL LADSLDLREH4440
 4441 MVGILFSRSK LSHLQKQVIV HIVHAIRKEA QRAKEDWELA NLAHVLKQSP QQQTAPALAA4500
 4501 SASCESTPER SRAPDTYCFE MLSMVLALSG SVVGRSYLSQ QHGLLRDLLG LLHTGSDRVQ4560
 4561 RQVTALLRRI LPEITPESFA ELLGVQRLPP ADYSIAHQSA SDFDMSRLGL LDIFLAVIAK4620
 4621 SLQLQVKVKT TVASTGPSGS GGVSGSSSGN GGAVLKAGQQ EKTPAFVRLW SSLDLSVQQL4680
 4681 RSRPPTGEPG TTDPFQFDAL PPRKESKRNL NQRWFLNGVI STKQAESIIS LIRDLASGKL4740
 4741 SEKWSQITKA AIAESVLNLT RLEEIYRSPE HCTKTSTLWL ALASLCVLER DHVEKLSSGQ4800
 4801 WSKLCDTRPL CSNHDDGETA AIIQCETCGS LCGDCDRFLH LNRKTRSHKR TVCKEEEEAI4860
 4861 RVELHESCGR TKLFWLLALA DSKTLKAMVE FRDGSHTIIS GPQEAVGRCR FCGLTGNSGL4920
 4921 LEIGNVCADA QCQEYAANSC LKTKPCGHAC GGVTGERKCL PCLQHVCHTR ENELAEELRD4980
 4981 PKLTQDADDM CMICFVEALS CAPSIHLECG HVFHYHCCKA VLEKRWSGPR ITFGFSLCPI5040
 5041 CKADIQHPLL SDILEPINGL KQDVKRKALM RIKYEGVVKD TDSKNVNMTQ LAMDRYAYYV5100
 5101 CFKCQKAYYG GEARCDAEIG EKFDPEELVC GGCSDVARAQ MCPKHGTDFL EYKCRYCCSV5160
 5161 AVFFCFGTTH FCDTCHDDFQ RLTNIPKVKL PQCPAGPKAK QLLGDECPLH VMHPPTGEEF5220
 5221 ALGCGVCRNA QTF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.44

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle