Protein Overview: FBpp0293150

General Information:
Name(s) found:	FBpp0293150 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|226703867\|sp\|P29617.3\|PROS_DROME RecName: Full=Homeobox protein prospero [NCBI NR] gi\|221378765\|ref\|NP_524317.3\| prospero, isoform F [Drosophila melanogaster] [NCBI NR] gi\|220903050\|gb\|AAF54628.3\| prospero, isoform F [Drosophila melanogaster] [NCBI NR] Homeobox protein prospero OS=Drosophila melanogaster GN=pros PE=1 SV=3 [Swiss-Prot] type=protein; loc=3R:join(7197912..7201560,7202044..7202998,7203729..7203911,7217251..7217395,7217640..7217819); ID=FBpp0293150; name=pros-PM; parent=FBgn0004595,FBtr0304608; dbxref=REFSEQ:NP_001247046,GB_protein:AFH06364,FlyBase:FBpp0293150,FlyBase_Annotation_IDs:CG17228-PM,FlyMine:FBpp0293150,modMine:FBpp0293150; MD5=fe7616ff503871acc90613745bebe137; length=1703; release=r5.56; species=Dmel; [FlyBase] The gene prospero is referred to in FlyBase by the symbol Dmel\pros (CG17228, FBgn0004595). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7197709..7219326. It has the cytological map location 86E2-86E4. There is experimental evidence that it has the molecular function</span>: transcription factor activity; specific transcriptional repressor activity; DNA binding. There is experimental evidence for 16 unique biological process</span> terms, many of which group under: anatomical structure development; regulation of neurogenesis; cell projection organization; regulation of developmental process; central nervous system development; regulation of biological process; transport; system process; neuron differentiation; cell proliferation; cellular component movement; gliogenesis; synapse organization; sensory organ development; sensory perception; dendrite morphogenesis; endocytosis. 161 alleles are reported. The phenotypes of these alleles are annotated with 41 unique terms, many of which group under: embryonic nervous system; nervous system; organ system; embryonic glial cell; peripheral nervous system; multi-cell-component structure; primordium; embryonic neuron; commissure; ventral nerve cord primordium. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] (AE003691) pros gene product [Drosophila melanogaster] [yeastflysequest.fasta] type=protein; loc=3R:join(7197912..7201560,7202044..7202998,7203729..7203911,7217251..7217395,7217640..7217819); ID=FBpp0271704; name=pros-PF; parent=FBgn0004595,FBtr0273196; dbxref=FlyBase_Annotation_IDs:CG17228-PF,FlyBase:FBpp0271704,REFSEQ:NP_524317,GB [fly-100309-contam.fasta] type=protein; loc=3R:join(7197912..7201560,7202044..7202998,7203729..7203911,7217251..7217395,7217640..7217819); ID=FBpp0271704; name=pros-PF; parent=FBgn0004595,FBtr0273196; dbxref=FlyBase_Annotation_IDs:CG17228-PF,FlyBase:FBpp0271704,REFSEQ:NP_524317,GB_protein:AAF54628; MD5=fe7616ff503871acc90613745bebe137; length=1703; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3R:join(7197912..7201560,7202044..7202998,7203729..7203911,7217251..7217395,7217640..7217819); ID=FBpp0271704; name=pros-PF; parent=FBgn0004595,FBtr0273196; dbxref=FlyBase_Annotation_IDs:CG17228-PF,FlyBase:FBpp0271704,REFSEQ:NP_524317,GB_protein:AAF54628; MD5=fe7616ff503871acc90613745bebe137; length=1703; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=3R:join(7197912..7201560,7202044..7202998,7203729..7203911,7217251..7217395,7217640..7217819); ID=FBpp0293150; name=pros-PM; parent=FBgn0004595,FBtr0304608; dbxref=REFSEQ:NP_001247046,GB_protein:AFH06364,FlyBase:FBpp0293150,FlyBase_Annotation_IDs:CG17228-PM,FlyMine:FBpp0293150,modMine:FBpp0293150; MD5=fe7616ff503871acc90613745bebe137; length=1703; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3R:join(11372190..11375838,11376322..11377276,11378007..11378189,11391529..11391673,11391918..11392097); ID=FBpp0293150; name=pros-PM; parent=FBgn0004595,FBtr0304608; dbxref=REFSEQ:NP_001247046,GB_protein:AFH06364,FlyBase:FBpp0293150,FlyBase_Annotation_IDs:CG17228-PM,FlyMine:FBpp0293150,modMine:FBpp0293150; MD5=fe7616ff503871acc90613745bebe137; length=1703; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3R:join(11372190..11375838,11376322..11377276,11378007..11378189,11391529..11391673,11391918..11392097); ID=FBpp0293150; name=pros-PM; parent=FBgn0004595,FBtr0304608; dbxref=REFSEQ:NP_001247046,GB_protein:AFH06364,FlyBase:FBpp0293150,FlyBase_Annotation_IDs:CG17228-PM,FlyMine:FBpp0293150,modMine:FBpp0293150; MD5=fe7616ff503871acc90613745bebe137; length=1703; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Isoform of P29617, Prospero, isoform M OS=Drosophila melanogaster GN=pros PE=4 SV=1 [DROME.fasta.20160308] FBpp0293150 type=protein; loc=3R:join(11372190..11375838,11376322..11377276,11378007..11378189,11391529..11391673,11391918..11392097); ID=FBpp0293150; name=pros-PM; parent=FBgn0004595,FBtr0304608; dbxref=REFSEQ:NP_001247046,GB_protein:AFH06364,FlyBase:FBpp0293150,FlyBase_Annotation_IDs:CG17228-PM,FlyMine:FBpp0293150,modMine:FBpp0293150; MD5=fe7616ff503871acc90613745bebe137; length=1703; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3R:join(11372190..11375838,11376322..11377276,11378007..11378189,11391529..11391673,11391918..11392097); ID=FBpp0293150; name=pros-PM; parent=FBgn0004595,FBtr0304608; dbxref=REFSEQ:NP_001247046,GB_protein:AFH06364,FlyBase:FBpp0293150,FlyBase_Annotation_IDs:CG17228-PM,UniProt/Swiss-Prot:P29617,FlyMine:FBpp0293150,modMine:FBpp0293150; MD5=fe7616ff503871acc90613745bebe137; length=1703; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	1703 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA][ISS][NAS][TAS] basal part of cell [NAS][TAS] cell cortex [IDA][TAS] apical cortex [IDA] basal cortex [IDA][NAS] plasma membrane [IDA]
Biological Process:	axonogenesis involved in innervation [IMP] negative regulation of cell proliferation [IMP] nervous system development [IMP][NAS][TAS] axon guidance [IMP] regulation of neuron differentiation [IMP] regulation of transcription [IEA] compound eye cone cell fate commitment [TAS] dendrite morphogenesis [IMP] neuroblast proliferation [IMP] negative regulation of neuroblast proliferation [IMP] phagocytosis, engulfment [IMP] axonogenesis [IMP][NAS] cell fate specification [TAS] sensory perception of taste [IMP] R7 cell fate commitment [IMP][TAS] peripheral nervous system development [IMP][TAS] regulation of transcription, DNA-dependent [NAS][TAS] neuroblast fate determination [NAS][TAS] asymmetric cell division [TAS] brain development [IMP] sensory organ development [TAS] ganglion mother cell fate determination [TAS] ventral cord development [TAS] synapse assembly [IMP] central nervous system development [IMP][TAS] eye photoreceptor cell differentiation [TAS] courtship behavior [TAS] glial cell differentiation [IMP]
Molecular Function:	DNA binding [IDA] transcription factor activity [IMP][NAS][TAS] transcription regulator activity [NAS] specific transcriptional repressor activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSSEEYEAD CFGLYSDENN VLLKANEPET TAATKQQHQP QFQQQQQQQQ QQQQHHHQHQ  60
   61 QPPPSSNGHT SPIPSQVNGD GSAANCGESG KTNTNTGSHS HSNSGNTNTD ADKEQEREKA 120
  121 KEKANEEESE DSDDDVVVVL EGCEGNASSS SSSSNSNSNA SSNNHKAAAT TTTTATTANH 180
  181 CNRSGGSSRS HRSARSSRQI SQSTAVGKTT TCAAKKPTAA QATTTTAKNS NSNSNVNVNV 240
  241 NVNSNGSGNG NANSKVNRRS RQRSLSKDIN NQPASSNSNS NSSNNSSNSN GGATATAAGF 300
  301 MSSAAAAAAG AAGGGALFQP QSVSTANSSS SNNNNSSTPA ALATHSPTSN SPVSGASSAS 360
  361 SLLTAAFGNL FGGSSAKMLN ELFGRQMKQA QDATSGLPQS LDNAMLAAAM ETATSAELLI 420
  421 GSLNSTSKLL QQQHNNNSIA PANSTPMSNG TNASISPGSA HSSSHSHQGV SPKGSRRVSA 480
  481 CSDRSLEAAA ADVAGGSPPR AASVSSLNGG ASSGEQHQSQ LQHDLVAHHM LRNILQGKKE 540
  541 LMQLDQELRT AMQQQQQQLQ EKEQLHSKLN NNNNNNIAAT ANNNNNTTME SINLIDDSEM 600
  601 ADIKIKSEPQ TAPQPQQSPH GSSHSSRSGS GSGSHSSMAS DGSLRRKSSD SLDSHGAQDD 660
  661 AQDEEDAAPT GQRSESRAPE EPQLPTKKES VDDMLDEVEL LGLHSRGSDM DSLASPSHSD 720
  721 MMLLDKDDVL DEDDDDDCVE QKTSGSGCLK KPGMDLKRAR VENIVSGMRC SPSSGLAQAG 780
  781 QLQVNGCKKR KLYQPQQHAM ERYVAAAAGL NFGLNLQSMM LDQEDSESNE LESPQIQQKR 840
  841 VEKNALKSQL RSMQEQLAEM QQKYVQLCSR MEQESECQEL DQDQDVEQEQ EPDNGSSDHI 900
  901 ELSPSPTLTG DGDVSPNHKE ETGQERPGSS SPSPSPLKPK TSLGESSDSG ANMLSQMMSK 960
  961 MMSGKLHNPL VGVGHPALPQ GFPPLLQHMG DMSHAAAMYQ QFFFEQEARM AKEAAEQQQQ1020
 1021 QQQQQQQQQQ QQQQEQQRRF EQEQQEQQRR KEEQQQQIQR QQQHLQQLQQ QQMEQQHVAT1080
 1081 AAPRPQMHHP APARLPTRMG GAAGHTALKS ELSEKFQMLR ANNNSSMMRM SGTDLEGLAD1140
 1141 VLKSEITTSL SALVDTIVTR FVHQRRLFSK QADSVTAAAE QLNKDLLLAS QILDRKSPRT1200
 1201 KVADRPQNGP TPATQSAAAM FQAPKTPQGM NPVAAAALYN SMTGPFCLPP DQQQQQQTAQ1260
 1261 QQQSAQQQQQ SSQQTQQQLE QNEALSLVVT PKKKRHKVTD TRITPRTVSR ILAQDGVVPP1320
 1321 TGGPPSTPQQ QQQQQQQQQQ QQQQQQQQAS NGGNSNATPA QSPTRSSGGA AYHPQPPPPP1380
 1381 PPMMPVSLPT SVAIPNPSLH ESKVFSPYSP FFNPHAAAGQ ATAAQLHQHH QQHHPHHQSM1440
 1441 QLSSSPPGSL GALMDSRDSP PLPHPPSMLH PALLAAAHHG GSPDYKTCLR AVMDAQDRQS1500
 1501 ECNSADMQFD GMAPTISFYK QMQLKTEHQE SLMAKHCESL TPLHSSTLTP MHLRKAKLMF1560
 1561 FWVRYPSSAV LKMYFPDIKF NKNNTAQLVK WFSNFREFYY IQMEKYARQA VTEGIKTPDD1620
 1621 LLIAGDSELY RVLNLHYNRN NHIEVPQNFR FVVESTLREF FRAIQGGKDT EQSWKKSIYK1680
 1681 IISRMDDPVP EYFKSPNFLE QLE

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.53

Protein Overview: FBpp0293150

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: