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Protein Overview: PARP1_ARATH

General Information:
Name(s) found: PARP1_ARATH [Swiss-Prot]
Description(s) found:
Found 16 descriptions.
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  • Poly [ADP-ribose] polymerase 1 OS=Arabidopsis thaliana GN=PARP1 PE=1 SV=2 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 983 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA][ISS]
    intracellular [IEA]
    Biological Process: DNA repair [IEP]
    response to oxidative stress [IEP]
    response to abiotic stimulus [IMP]
    response to abscisic acid stimulus [IEP]
    protein amino acid ADP-ribosylation [ISS]
    Molecular Function: DNA binding [IEA][ISS]
    zinc ion binding [IEA]
    NAD or NADH binding [IEA]
    NAD+ ADP-ribosyltransferase activity [IEA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASPHKPWRA EYAKSSRSSC KTCKSVINKE NFRLGKLVQS THFDGIMPMW NHASCILKKT  60
   61 KQIKSVDDVE GIESLRWEDQ QKIRKYVESG AGSNTSTSTG TSTSSTANNA KLEYGIEVSQ 120
  121 TSRAGCRKCS EKILKGEVRI FSKPEGPGNK GLMWHHAKCF LEMSSSTELE SLSGWRSIPD 180
  181 SDQEALLPLV KKALPAAKTE TAEARQTNSR AGTKRKNDSV DNEKSKLAKS SFDMSTSGAL 240
  241 QPCSKEKEME AQTKELWDLK DDLKKYVTSA ELREMLEVNE QSTRGSELDL RDKCADGMMF 300
  301 GPLALCPMCS GHLSFSGGLY RCHGYISEWS KCSHSTLDPD RIKGKWKIPD ETENQFLLKW 360
  361 NKSQKSVKPK RILRPVLSGE TSQGQGSKDA TDSSRSERLA DLKVSIAGNT KERQPWKKRI 420
  421 EEAGAEFHAN VKKGTSCLVV CGLTDIRDAE MRKARRMKVA IVREDYLVDC FKKQRKLPFD 480
  481 KYKIEDTSES LVTVKVKGRS AVHEASGLQE HCHILEDGNS IYNTTLSMSD LSTGINSYYI 540
  541 LQIIQEDKGS DCYVFRKWGR VGNEKIGGNK VEEMSKSDAV HEFKRLFLEK TGNTWESWEQ 600
  601 KTNFQKQPGK FLPLDIDYGV NKQVAKKEPF QTSSNLAPSL IELMKMLFDV ETYRSAMMEF 660
  661 EINMSEMPLG KLSKHNIQKG FEALTEIQRL LTESDPQPTM KESLLVDASN RFFTMIPSIH 720
  721 PHIIRDEDDF KSKVKMLEAL QDIEIASRIV GFDVDSTESL DDKYKKLHCD ISPLPHDSED 780
  781 YRLIEKYLNT THAPTHTEWS LELEEVFALE REGEFDKYAP HREKLGNKML LWHGSRLTNF 840
  841 VGILNQGLRI APPEAPATGY MFGKGIYFAD LVSKSAQYCY TCKKNPVGLM LLSEVALGEI 900
  901 HELTKAKYMD KPPRGKHSTK GLGKKVPQDS EFAKWRGDVT VPCGKPVSSK VKASELMYNE 960
  961 YIVYDTAQVK LQFLLKVRFK HKR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..63] PSI-BLAST 22.69897 Solution structure of the first Zn-finger domain of poly(ADP-ribose) polymerase-1
    2 View Details [64..475] PSI-BLAST 50.522879 No description for 2owoA was found.
    3 View Details [476..635] PSI-BLAST 21.0 Solution structure of WGR domain of poly(ADP-ribose) polymerase-1
    4 View Details [636..983] PSI-BLAST 104.0 Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase with a novel inhibitor


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle