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View Structure Prediction Details

Protein: PARP1_ARATH
Organism: Arabidopsis thaliana
Length: 983 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

No multiple sequence alignment data found for PARP1_ARATH.

Predicted Domain #1
Region A:
Residues: [1-63]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASPHKPWRA EYAKSSRSSC KTCKSVINKE NFRLGKLVQS THFDGIMPMW NHASCILKKT  60
   61 KQI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.69897
Match: 1v9xA
Description: Solution structure of the first Zn-finger domain of poly(ADP-ribose) polymerase-1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [64-475]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSVDDVEGIE SLRWEDQQKI RKYVESGAGS NTSTSTGTST SSTANNAKLE YGIEVSQTSR  60
   61 AGCRKCSEKI LKGEVRIFSK PEGPGNKGLM WHHAKCFLEM SSSTELESLS GWRSIPDSDQ 120
  121 EALLPLVKKA LPAAKTETAE ARQTNSRAGT KRKNDSVDNE KSKLAKSSFD MSTSGALQPC 180
  181 SKEKEMEAQT KELWDLKDDL KKYVTSAELR EMLEVNEQST RGSELDLRDK CADGMMFGPL 240
  241 ALCPMCSGHL SFSGGLYRCH GYISEWSKCS HSTLDPDRIK GKWKIPDETE NQFLLKWNKS 300
  301 QKSVKPKRIL RPVLSGETSQ GQGSKDATDS SRSERLADLK VSIAGNTKER QPWKKRIEEA 360
  361 GAEFHANVKK GTSCLVVCGL TDIRDAEMRK ARRMKVAIVR EDYLVDCFKK QR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.522879
Match: 2owoA
Description: No description for 2owoA was found.

Predicted Domain #3
Region A:
Residues: [476-635]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLPFDKYKIE DTSESLVTVK VKGRSAVHEA SGLQEHCHIL EDGNSIYNTT LSMSDLSTGI  60
   61 NSYYILQIIQ EDKGSDCYVF RKWGRVGNEK IGGNKVEEMS KSDAVHEFKR LFLEKTGNTW 120
  121 ESWEQKTNFQ KQPGKFLPLD IDYGVNKQVA KKEPFQTSSN 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.0
Match: 2cr9A
Description: Solution structure of WGR domain of poly(ADP-ribose) polymerase-1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [636-983]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAPSLIELMK MLFDVETYRS AMMEFEINMS EMPLGKLSKH NIQKGFEALT EIQRLLTESD  60
   61 PQPTMKESLL VDASNRFFTM IPSIHPHIIR DEDDFKSKVK MLEALQDIEI ASRIVGFDVD 120
  121 STESLDDKYK KLHCDISPLP HDSEDYRLIE KYLNTTHAPT HTEWSLELEE VFALEREGEF 180
  181 DKYAPHREKL GNKMLLWHGS RLTNFVGILN QGLRIAPPEA PATGYMFGKG IYFADLVSKS 240
  241 AQYCYTCKKN PVGLMLLSEV ALGEIHELTK AKYMDKPPRG KHSTKGLGKK VPQDSEFAKW 300
  301 RGDVTVPCGK PVSSKVKASE LMYNEYIVYD TAQVKLQFLL KVRFKHKR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 104.0
Match: 1uk0A
Description: Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase with a novel inhibitor
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle