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Protein Overview: hif-1

General Information:
Name(s) found: hif-1 / CE38182 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00001851 locus:hif-1 Hypoxia-inducible factor 1 status:Confirmed UniProt:G5EGD2 protein_id:CAB07380.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 719 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IEALink to PubMed article]
    Biological Process: response to hypoxia [IMPLink to PubMed article]
    signal transduction [IEALink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    regulation of transcription [IEALink to PubMed article]
    Molecular Function: transcription factor activity [ISSLink to PubMed article]
    transcription regulator activity [IEALink to PubMed article]
    signal transducer activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDNRKRNME RRRETSRHAA RDRRSKESDI FDDLKMCVPI VEEGTVTHLD RIALLRVAAT  60
   61 ICRLRKTAGN VLENNLDNEI TNEVWTEDTI AECLDGFVMI VDSDSSILYV TESVAMYLGL 120
  121 TQTDLTGRAL RDFLHPSDYD EFDKQSKMLH KPRGEDTDTT GINMVLRMKT VISPRGRCLN 180
  181 LKSALYKSVS FLVHSKVSTG GHVSFMQGIT IPAGQGTTNA NASAMTKYTE SPMGAFTTRH 240
  241 TCDMRITFVS DKFNYILKSE LKTLMGTSFY ELVHPADMMI VSKSMKELFA KGHIRTPYYR 300
  301 LIAANDTLAW IQTEATTITH TTKGQKGQYV ICVHYVLGIQ GAEESLVVCT DSMPAGMQVD 360
  361 IKKEVDDTRD YIGRQPEIVE CVDFTPLIEP EDPFDTVIEP VVGGEEPVKQ ADMGARKNSY 420
  421 DDVLQWLFRD QPSSPPPARY RSADRFRTTE PSNFGSALAS PDFMDSSSRT SRPKTSYGRR 480
  481 AQSQGSRTTG SSSTSASATL PHSANYSPLA EGISQCGLNS PPSIKSGQVV YGDARSMGRS 540
  541 CDPSDSSRRF SALSPSDTLN VSSTRGINPV IGSNDVFSTM PFADSIAIAE RIDSSPTLTS 600
  601 GEPILCDDLQ WEEPDLSCLA PFVDTYDMMQ MDEGLPPELQ ALYDLPDFTP AVPQAPAARP 660
  661 VHIDRSPPAK RMHQSGPSDL DFMYTQHYQP FQQDETYWQG QQQQNEQQPS SYSPFPMLS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..74] PSI-BLAST 4.154902 Pho4 B/HLH domain
    2 View Details [75..454] PSI-BLAST 48.09691 Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD
    3 View Details [455..525] deduced N/A No confident structure predictions are available.
    4 View Details [526..719] MSA 12.367997 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle