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Protein Overview: FBpp0293728, Can...

General Information:
Name(s) found: FBpp0305092 [FlyBase]
FBpp0293728 [FlyBase]
CanA-14F-PB / FBpp0074068 [FlyBase]
CanA-14F-PA / FBpp0074067 [FlyBase]
Description(s) found:
Found 45 descriptions.
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  • type=protein; loc=X:complement(16460309..16462063); ID=FBpp0305092; name=CanA-14F-PD; parent=FBgn0030758,FBtr0332870; dbxref=REFSEQ:NP_001259622,GB_protein:AGB95464,FlyBase:FBpp0305092,FlyBase_Annotation_IDs:CG9819-PD; MD5=c179e4a06f457ebbf9aa3f1a0f5582fc; length=584; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=X:complement(16460309..16462063); ID=FBpp0293728; name=CanA-14F-PC; parent=FBgn0030758,FBtr0305198; dbxref=REFSEQ:NP_001245717,GB_protein:AFH07430,FlyBase:FBpp0293728,FlyBase_Annotation_IDs:CG9819-PC; MD5=c179e4a06f457ebbf9aa3f1a0f5582fc; length=584; release=r5.56; species=Dmel; [FlyBase]
  • The gene Calcineurin A at 14F is referred to in FlyBase by the symbol Dmel\CanA-14F (CG9819, FBgn0030758). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16459506..16481160. It has the cytological map location 14E3-14F1. Based on sequence similarity, it is predicted to have molecular function</span>: protein serine/threonine phosphatase activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of NFAT protein import into nucleus. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Calcineurin A at 14F is referred to in FlyBase by the symbol Dmel\CanA-14F (CG9819, FBgn0030758). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16459506..16481160. It has the cytological map location 14E3-14F1. Based on sequence similarity, it is predicted to have molecular function</span>: protein serine/threonine phosphatase activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of NFAT protein import into nucleus. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 584 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: positive regulation of NFAT protein import into nucleus [IMP]
    protein amino acid dephosphorylation [NAS]
    Molecular Function: protein serine/threonine phosphatase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSPAAQSNS SSSQSQSAAQ QQQQQNQKAN VNNTHDNKNA AATTGTAAGS GSGGAAGSAG  60
   61 TQQQGQGGTG TSSGPSSPTK RSTISTKERV IDSVAFPPSR KLTCADVFDA RTGKPQHDVL 120
  121 KQHFILEGRI EESAALRIIQ EGATLLRTEK TMIDIEAPVT VCGDIHGQFY DLMKLFEIGG 180
  181 SPATTKYLFL GDYVDRGYFS IECVLYLWSL KITYPQTLFL LRGNHECRHL TEYFTFKQEC 240
  241 KIKYSERVYD ACMDAFDCLP LAALMNQQFL CVHGGLSPEI HELEDIRRLD RFKEPPAFGP 300
  301 MCDLLWSDPL EDFGNEKNSD FYTHNSVRGC SYFYSYAACC DFLQNNNLLS IIRAHEAQDA 360
  361 GYRMYRKSQT TGFPSLITIF SAPNYLDVYN NKAAVLKYEN NVMNIRQFNC SPHPYWLPNF 420
  421 MDVFTWSLPF VGEKVTEMLV NVLNICSDDE LMTEESEEPL SDDEAALRKE VIRNKIRAIG 480
  481 KMARVFSVLR EESESVLQLK GLTPTGALPL GALSGGKQSL KNAMQGFSPN HKITSFAEAK 540
  541 GLDAVNERMP PRRDATPSPA EEGQKSLSAA AAAAANANAN SING

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..97] PSI-BLAST 84.69897 PP5 structure
    2 View Details [98..584] PSI-BLAST 171.0 Protein phosphatase-2B (PP-2B, calcineurin A subunit)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  11.6417995308386 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  10.6440947462013 bayes_pls_golite062009
  • phosphatase activity
    		•  10.5525832502704 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  10.3702645338723 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  9.02791306892273 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  7.59009048424811 bayes_pls_golite062009
  • myosin phosphatase activity
    		•  5.31703100176823 bayes_pls_golite062009
  • hydrolase activity
    		•  3.13006743434485 bayes_pls_golite062009
  • structural constituent of muscle
    		•  2.91086263632625 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68552051869632 bayes_pls_golite062009
  • kinase activity
    		•  1.67788383575784 bayes_pls_golite062009
  • structural molecule activity
    		•  1.5850868178597 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57807175808088 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4514460578232 bayes_pls_golite062009
  • binding
    		•  1.44538582463569 bayes_pls_golite062009
  • catalytic activity
    		•  1.39852585255405 bayes_pls_golite062009
  • transferase activity
    		•  1.3407391509244 bayes_pls_golite062009
  • protein binding
    		•  1.33435965029646 bayes_pls_golite062009
  • transporter activity
    		•  1.24767072239634 bayes_pls_golite062009
  • signal transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • calmodulin binding
    		•  0.77173071932406 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.66803085638835 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.528189469950839 bayes_pls_golite062009
  • protein transporter activity
    		•  0.10469955758282 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.81

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle