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Protein Overview: vps-34

General Information:
Name(s) found: vps-34 / CE37738 [WormBase]
Description(s) found:
Found 12 descriptions.
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  • WBGene00006932 locus:vps-34 status:Partially_confirmed UniProt:Q5TYK7 protein_id:AAV58893.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 716 amino acids

    Gene Ontology:
    Cellular Component: phosphoinositide 3-kinase complex [IEALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    nuclear outer membrane [IDALink to PubMed article]
    Biological Process: nuclear envelope organization [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    regulation of protein secretion [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed article]
    phosphoinositide-mediated signaling [IEALink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed article]
    ecdysis, collagen and cuticulin-based cuticle [IMPLink to PubMed article]
    phosphoinositide phosphorylation [IEALink to PubMed article]
    regulation of endocytosis [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: inositol or phosphatidylinositol kinase activity [IEALink to PubMed article]
    phosphotransferase activity, alcohol group as acceptor [IEALink to PubMed article]
    1-phosphatidylinositol-3-kinase activity [IDALink to PubMed article][IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRATPTESFS FVYSCDLQTN VQVKVAEFEG IFRDVLNPVR RLNQLFAEIT VYCNNQQIGY  60
   61 PVCTSFHTPP DSSQLARQKL IQKWNEWLTL PIRYSDLSRD AFLHITIWEH EDDEIVNNST 120
  121 FSRRLVAQSK LSMFSKRGIL KSGVIDVQMN VSTTPDPFVK QPETWKYSDA WGDEIDLLFK 180
  181 QVTRQSRGLV EDVPWLDPFA SRRIEMIRAK YKYSSPDRHV FLVLEMAAIR LGPTFYKVVY 240
  241 YEDETKNMRV STSVNGGVGI VSACTRYCVA DPELLLESLA EVKHSAMTRR IRDVEDERHR 300
  301 QVKPNKQAKD RLETIVNLPS SQVLTREQRD LVWKFRHYLR QFPKALNKYL RSVNWVHPQE 360
  361 VKTALALMND WELIEAEDAL ELLSSAFTHP AVRAYSVSRL LEAASPEQVL LYLPQLVQAL 420
  421 KYEQGQQLPE EGNPVPVVSE EEGKIPSVAT TPTEELEGRD MTVVTKKEAR KAASGDLATF 480
  481 LIDYALASPK VSNYLYWHLK TEIESTKESK EEHSKMYQNI QDRLMEALVK RPDTRAQVDS 540
  541 LHQQQIFVED LIILMNEAKA RGGRLNESKS AEFRTMLSRA KHMLDLKGVH LPLDPSFRLS 600
  601 SVIPDTASFF KSEMMPAKIS FKVLQPNGKA DRNIPEEYTV IFKTGDDLRQ DQLIQQMVRL 660
  661 IDIILKKGQL DLKLTPYLVR NIYIYIKFVE EIVNIAKKNK SRKSTRKIYE ILLKFI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..97] MSA 4.068996 View MSA. No confident structure predictions are available.
    2 View Details [98..716] PSI-BLAST 104.0 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  0.0934358341245259 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle