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View Structure Prediction Details

Protein: vps-34
Organism: Caenorhabditis elegans
Length: 716 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for vps-34.

Description E-value Query
Range
Subject
Range
vps-34 - phosphatidylinositol 3-kinase status:Confirmed UniProt:Q9TXI7 protein_id:AAF23184.1
574.0 [0..1] [705..5]

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Predicted Domain #1
Region A:
Residues: [1-97]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRATPTESFS FVYSCDLQTN VQVKVAEFEG IFRDVLNPVR RLNQLFAEIT VYCNNQQIGY  60
   61 PVCTSFHTPP DSSQLARQKL IQKWNEWLTL PIRYSDL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [98-716]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRDAFLHITI WEHEDDEIVN NSTFSRRLVA QSKLSMFSKR GILKSGVIDV QMNVSTTPDP  60
   61 FVKQPETWKY SDAWGDEIDL LFKQVTRQSR GLVEDVPWLD PFASRRIEMI RAKYKYSSPD 120
  121 RHVFLVLEMA AIRLGPTFYK VVYYEDETKN MRVSTSVNGG VGIVSACTRY CVADPELLLE 180
  181 SLAEVKHSAM TRRIRDVEDE RHRQVKPNKQ AKDRLETIVN LPSSQVLTRE QRDLVWKFRH 240
  241 YLRQFPKALN KYLRSVNWVH PQEVKTALAL MNDWELIEAE DALELLSSAF THPAVRAYSV 300
  301 SRLLEAASPE QVLLYLPQLV QALKYEQGQQ LPEEGNPVPV VSEEEGKIPS VATTPTEELE 360
  361 GRDMTVVTKK EARKAASGDL ATFLIDYALA SPKVSNYLYW HLKTEIESTK ESKEEHSKMY 420
  421 QNIQDRLMEA LVKRPDTRAQ VDSLHQQQIF VEDLIILMNE AKARGGRLNE SKSAEFRTML 480
  481 SRAKHMLDLK GVHLPLDPSF RLSSVIPDTA SFFKSEMMPA KISFKVLQPN GKADRNIPEE 540
  541 YTVIFKTGDD LRQDQLIQQM VRLIDIILKK GQLDLKLTPY LVRNIYIYIK FVEEIVNIAK 600
  601 KNKSRKSTRK IYEILLKFI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 104.0
Match: 1e7vA
Description: Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.0934358341245259 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle