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Protein Overview: peb-PB, peb-PA

General Information:
Name(s) found: peb-PB / FBpp0099653 [FlyBase]
peb-PA / FBpp0070648 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • The gene pebbled is referred to in FlyBase by the symbol Dmel\peb (CG12212, FBgn0003053). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:4511602..4520256. It has the cytological map location 4C10. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: anatomical structure development; sensory organ development; embryonic development via the syncytial blastoderm; open tracheal system development; tissue homeostasis; organ development; regulation of biological process; embryonic development ending in birth or egg hatching; organ morphogenesis; ommatidial rotation; anterior/posterior axis specification; negative regulation of MAPKKK cascade. 24 alleles are reported. The phenotypes of these alleles are annotated with 19 unique terms, many of which group under: organ system; cephalopharyngeal skeleton; cuticle; extended germ band embryo; external compound sense organ; embryonic/larval tracheal system; portion of tissue; pharyngeal sclerite; peripheral nervous system; taenidial fold; rhabdomere; nervous system; tracheal system; spiracle; late extended germ band embryo. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene pebbled is referred to in FlyBase by the symbol Dmel\peb (CG12212, FBgn0003053). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:4511602..4520256. It has the cytological map location 4C10. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: anatomical structure development; sensory organ development; embryonic development via the syncytial blastoderm; open tracheal system development; tissue homeostasis; organ development; regulation of biological process; embryonic development ending in birth or egg hatching; organ morphogenesis; ommatidial rotation; anterior/posterior axis specification; negative regulation of MAPKKK cascade. 24 alleles are reported. The phenotypes of these alleles are annotated with 19 unique terms, many of which group under: organ system; cephalopharyngeal skeleton; cuticle; extended germ band embryo; external compound sense organ; embryonic/larval tracheal system; portion of tissue; pharyngeal sclerite; peripheral nervous system; taenidial fold; rhabdomere; nervous system; tracheal system; spiracle; late extended germ band embryo. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1894 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    Biological Process: dorsal closure [IMP][TAS]
    torso signaling pathway [IGI]
    germ-band shortening [IMP][TAS]
    ommatidial rotation [IMP]
    terminal region determination [IGI]
    photoreceptor cell morphogenesis [IMP]
    dorsal closure, leading edge cell fate determination [NAS]
    regulation of tube architecture, open tracheal system [TAS]
    head involution [NAS]
    establishment of ommatidial planar polarity [IMP]
    amnioserosa maintenance [IMP][TAS]
    maintenance of epithelial integrity, open tracheal system [IMP]
    ectoderm development [TAS]
    regulation of transcription [ISS][NAS]
    negative regulation of JNK cascade [IGI]
    compound eye development [IMP]
    open tracheal system development [IEP]
    wing disc dorsal/ventral pattern formation [IGI]
    Molecular Function: transcription factor activity [ISS]
    zinc ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLAAQQQHNN STVESEMERQ RRDSTTSESS LEHLDLGRTP KKLGGNSGST QTTSTPHELA  60
   61 TVTSSRKRKI RHLQLNHHQQ QQHHQQSDLL SDEDVAEAEA EEDEDEEDGD QVAALGSRNL 120
  121 GRHKQRRSGG ATTQASIVMD YSSGDASSLR KKFRLNRSAA SLSESGFVDA SSTTGHSGYL 180
  181 GNSSSATNTT ATSGIGASAV APSPVGGAAI NAASSSSGSS SGGSGGSSPQ GQCLSSGESG 240
  241 IGAGDEHMKY LCPICEVVSA TPHEFTNHIR CHNYANGDTE NFTCRICSKV LSSASSLDRH 300
  301 VLVHTGERPF NCRYCHLTFT TNGNMHRHMR THKQHQVAQS QSQSQQQQSL QQQQQSQQQR 360
  361 RQQQQHQPSQ QQQNPAQQQL MGNTLSARAE SYESDASCST DVSSGHSHSR SSSSLNNNNN 420
  421 NSHKANNNLK DLEELEVSTE DQDTENKQRR LKTTINNNII ESEQQEDMDD EEADDADVAM 480
  481 LTSTPDVATL LAGASASGAA SRSPTPSPSA SPALLLSCPA CGASDFETLP ALCVHLDAMH 540
  541 SDIPAKCRDC EVIFATHRQL QSHCCRLPNA LAGGLPPLLG ASSSPLHNEE PEDEEHGDDE 600
  601 DLEQKERLAS QSEDFFHQLY LKHKTANGCG AISHPPSPIK HEPADTKDLA DIQSILNMTS 660
  661 SSSSFLRNFE QSVNTPNSSQ YSLDGRDQEE EAQDAFTSEF RRMKLRGEFP CKLCTAVFPN 720
  721 LRALKGHNRV HLGAVGPAGP FRCNMCPYAV CDKAALVRHM RTHNGDRPYE CAVCNYAFTT 780
  781 KANCERHLRN RHGKTSREEV KRAIVYHPAE DAGCEDSKSR LGEDLADTSF RSISPTPPPP 840
  841 PVNESKSQLK HMLLGENHLA PVNQQPPLKI QVKSLDQLVD KKPSAPAPQQ QQQQQQQEKS 900
  901 GSALDFSMDV LDLSKKPTGG ASLTPAVTRT PTPAAVAPVT PGGVGTPDLA AAIEQQQLLL 960
  961 AQQQLFGAGG EYMQQLFRSL MFQSQTSGFP FFPFMAPPPP QANPEKPPMV SPPNRINPMP1020
 1021 VGVGVGVPVP PGGPVKMVIK NGVLMPKQKQ RRYRTERPFA CEHCSARFTL RSNMERHVKQ1080
 1081 QHPQFYAQRQ RSGHHVMRGR GASNVAAAAA AAAAAAAATV MAGGPGSSGF GSNHHHGHGH1140
 1141 GSHGSHGHAP ISEQVKCAIL AQQLKAHKNT DLLQQALAHG SSSVAGNPLL HFGYPLTNPS1200
 1201 PMHNGSSQGN GQATAMDDDE PKLIIDEDEN EHDHEVEAED VDDFEEDEDE EEMDEPEDEP1260
 1261 ELILDEQPAE KEAEEEQELP KPLEQLGTKE AAQKMAETIL EQAIKAGKPL SPPPTKENAS1320
 1321 PANPTVATTM QEPAITAPST NPSSLKTMIA QAEYVGKSLK EVASSPFKDE SQDLVPVAKL1380
 1381 VDNATSQNMG FNSYFRPSDV ANHMEQSDEE GLVASGSASE SNNSGTEDVT SSSSSSEPKK1440
 1441 KSAYSLAPNR VSCPYCQRMF PWSSSLRRHI LTHTGQKPFK CSHCPLLFTT KSNCDRHLLR1500
 1501 KHGNVESAMS VYVPTEDVSE PIPVPKSVEE IELEEQRRRQ EAEREKELEL ERERELERER1560
 1561 ELERERQLEK EKERERQQLI QKLAAQMNAA ATAAAVVAAA SAVNGGASGG PHGPIADALA1620
 1621 GGDLPYKCHL CEGSFAERLQ CLEHIKQAHA HEYALLLAKG AIETESLEAN PHQQPSQQAV1680
 1681 HSDDEAPNGG GNRGKYPDYS NRKVICAFCL RRFWSTEDLR RHMRTHSGER PFQCDICLRK1740
 1741 FTLKHSMLRH MKKHSGRAHN GDTPGSDCSD DEQVSSPPST PHPTQPTSAN NNNSCHNNNN1800
 1801 NANNNNNNNN NNNNNNSSSK LGLKLHDLLD KASEWRASRL GEHKENMGEA TPSGATVAGS1860
 1861 DLIGNLLGIS DQGILNKLLS SADEAAKLLG VDNK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] deduced N/A No confident structure predictions are available.
    2 View Details [216..398] PSI-BLAST 5.0 THE CRYSTAL STRUCTURE OF A ZINC FINGER - RNA COMPLEX REVEALS TWO MODES OF MOLECULAR RECOGNITION
    3 View Details [399..505] deduced N/A No confident structure predictions are available.
    4 View Details [506..609] FFAS03 0.997 ADR1 DNA-BINDING DOMAIN FROM SACCHAROMYCES CEREVISIAE, NMR, 25 STRUCTURES
    5 View Details [610..673] MSA 1.148996 View MSA. No confident structure predictions are available.
    6 View Details [674..806] PSI-BLAST 16.09691 No description for 2dlqA was found.
    7 View Details [807..904] deduced N/A No confident structure predictions are available.
    8 View Details [905..1250] FFAS03 4.1 No description for 2i13A was found.
    9 View Details [1251..1414] deduced N/A No confident structure predictions are available.
    10 View Details [1415..1672] PSI-BLAST 18.045757 Five-finger GLI1
    11 View Details [1673..1894] PSI-BLAST 60.0 No description for 2i13A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • binding
    		•  0.414217765611205 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10
    Term Confidence Notes
  • binding
    		•  0.414217765611205 bayes_pls_golite062009
    11 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.71

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle