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Protein Overview: gi|30263837, gi|...

General Information:
Name(s) found: gi|30263837 [NCBI NR]
gi|30258481 [NCBI NR]
Description(s) found:
Found 4 descriptions.
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  • gi|30263837|ref|NP_846214.1| DNA topoisomerase I [Bacillus anthracis str. Ames] [NCBI NR]
  • gi|30258481|gb|AAP27700.1| DNA topoisomerase I [Bacillus anthracis str. Ames] [NCBI NR]
    • Organism: Bacillus anthracis str. Ames
    Length: 692 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: DNA replication [ISSLink to PubMed article]
    DNA topological change [ISSLink to PubMed article]
    Molecular Function: DNA topoisomerase type I activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDYLVIVES PSKAKTIEKY LGKKYKVVAS MGHVRDLPKS QMGIEVKNNF TPKYITIRGK  60
   61 GPVLKDLKSA AKKAKKVYLA ADPDREGEAI AWHLANTLNV DVESDCRVVF NEITKDAIKE 120
  121 SFKHPRAINM DLVDAQQARR ILDRLVGYNI SPLLWKKVKK GLSAGRVQSV AVRLIIERER 180
  181 EIQSFEPEEF WTIKTEFVKG KDTFEASFYG VDGEKVQLTN ETQVNEIIEQ LKDNAFSVEN 240
  241 VTRKERKRNP ALPFTTSSLQ QEAARKLNMR AKKTMMLAQQ LYEGIDLGKQ GTVGLITYMR 300
  301 TDSTRISETA QTEARTYITE AYGTEYIGAE KKKETKKSNA QDAHEAIRPT SVMRKPEELK 360
  361 SFLSRDQLRL YKLIWERFVA SQMASAIMDT VTARLINNNV QFRASGSVVK FPGFMKVYVE 420
  421 SKDDGAEEKD KMLPPLEVGE TVFSKDLEPK QHFTQPPPRY TEARLVRTLE ELGIGRPSTY 480
  481 VPTLETIQKR GYVGLDNKRF VPTELGEIVI ELILEFFPEI INIEFTANME QSLDEVEEGN 540
  541 ANWVKIVDDF YVGFEPRLEK AEKEMREVEI KDEPAGEDCE LCNHPMVFKM GKYGKFMACS 600
  601 NFPDCRNTKP IVKEIGVTCP KCDKGQIIER RSNKKKRLFY GCGTYPECDF VSWDKPIGRK 660
  661 CPKCEGMLVE KKLKKGVQVQ CISCDYEEEQ QM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..578] PSI-BLAST 1000.0 AMINO TERMINAL 67KDA DOMAIN OF ESCHERICHIA COLI DNA TOPOISOMERASE I (RESIDUES 2-590 OF MATURE PROTEIN) CLONING ARTIFACT ADDS TWO RESIDUES TO THE AMINO-TERMINUS WHICH WERE NOT OBSERVED IN THE EXPERIMENTAL ELECTRON DENSITY (GLY-2, SER-1).
    2 View Details [579..692] FFAS03 1.46 No description for 2gaiA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA topoisomerase activity
    		•  9.28485802237784 bayes_pls_golite062009
  • DNA topoisomerase type I activity
    		•  6.20416707013367 bayes_pls_golite062009
  • isomerase activity
    		•  5.61256457337998 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.37048693883188 bayes_pls_golite062009
  • DNA binding
    		•  3.2732257752308 bayes_pls_golite062009
  • binding
    		•  3.07618319631815 bayes_pls_golite062009
  • catalytic activity
    		•  1.50449367975676 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle